Protein: TBL1R
F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)

Gene: TBL1R, TBL1XR1
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q9BZK7

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0001835 - blastocyst hatching
GO:0002021 - response to dietary excess

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

261440

TBL1X
F-box-like/WD repeat-containing protein TBL1X

4

17

Small-scale

0.890

High

1410246

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

2

17

High-throughput

0.811

High

783122

ARL2
ADP-ribosylation factor-like protein 2

2

6

High-throughput

0.811

High

980280

H4
Histone H4

2

7

Small-scale

0.768

High

1419997

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

2

12

Small-scale

0.754

High

278423

NCOR1
Nuclear receptor corepressor 1

9

20

Small-scale

0.751

High

188361

HDAC3
Histone deacetylase 3

7

16

Small-scale

0.746

High

1157912

DDB1
DNA damage-binding protein 1

1

12

Small-scale

0.724

High

1098594

GPS2
G protein pathway suppressor 2

5

2

High-throughput

0.716

High

520353

ANDR
Androgen receptor

5

20

Small-scale

0.702

High

905114

MECP2
Methyl-CpG-binding protein 2

4

7

Small-scale

0.699

High

396885

ESR1
Estrogen receptor

4

20

Small-scale

0.672

High

941054

HDAC4
Histone deacetylase 4

3

20

High-throughput

0.656

High

993736

UBC9
SUMO-conjugating enzyme UBC9

1

7

Small-scale

0.647

High

1163190

H2B2E
Histone H2B type 2-E

1

6

Small-scale

0.647

High

1314586

MKX
Homeobox protein Mohawk

2

4

High-throughput

0.628

High

927531

ATX1
Ataxin-1

2

3

High-throughput

0.628

High

1029745

FOXK2
Forkhead box protein K2

2

11

Small-scale

0.619

High

1245330

WDR59
GATOR2 complex protein WDR59

1

18

High-throughput

0.618

High

1402707

TCPQM
T-complex protein 1 subunit theta-like 2

1

20

High-throughput

0.618

High

854927

RECQ1
ATP-dependent DNA helicase Q1

1

18

High-throughput

0.618

High

906772

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

5

Small-scale

0.618

High

998776

H31
Histone H3.1

1

11

High-throughput

0.618

High

1381199

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

5

Small-scale

0.618

High

1419998

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1420008

HDAC5
Histone deacetylase 5

2

20

High-throughput

0.611

High

1420011

T22D4
TSC22 domain family protein 4

2

3

High-throughput

0.611

High

276722

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

8

High-throughput

0.609

High

1233792

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

143235

NFIB
Nuclear factor 1 B-type

2

11

High-throughput

0.584

High

242841

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

474263

NFIC
Nuclear factor 1 C-type

2

18

High-throughput

0.584

High

765015

CTNB1
Catenin beta-1

2

12

Small-scale

0.584

High

1111250

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.575

High

1234944

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.575

High

1255421

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.553

High

155348

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

2

High-throughput

0.536

High

221052

HAIR
Lysine-specific demethylase hairless

1

2

High-throughput

0.536

High

246923

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.536

High

857550

NOTC1
Neurogenic locus notch homolog protein 1

1

9

High-throughput

0.536

High

896448

ERF
ETS domain-containing transcription factor ERF

1

15

High-throughput

0.536

High

1017480

FOXK1
Forkhead box protein K1

1

12

High-throughput

0.536

High

1065414

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

1110051

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.536

High

1115988

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.536

High

1123099

FHL2
Four and a half LIM domains protein 2

1

4

High-throughput

0.536

High

1205771

EFMT2
EEF1A lysine methyltransferase 2

1

1

High-throughput

0.536

High

1287883

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

3

High-throughput

0.536

High

1327332

ZN276
Zinc finger protein 276

1

3

High-throughput

0.536

High

1356764

HDAC7
Histone deacetylase 7

1

20

High-throughput

0.536

High

555423

SKI
Ski oncogene

1

0

Small-scale

0.530

High

887203

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.527

High

895033

EMD
Emerin

1

2

Small-scale

0.515

High

1133643

NFIX
Nuclear factor 1 X-type

1

17

High-throughput

0.515

High

167390

KLF11
Krueppel-like factor 11

1

13

High-throughput

0.515

High

185995

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

15

High-throughput

0.501

High

160013

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.493

High

361352

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.493

High

160606

IRS4
Insulin receptor substrate 4

1

1

High-throughput

0.489

High

347304

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

652408

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.489

High

867401

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.489

High

885013

DGKG
Diacylglycerol kinase gamma

1

2

High-throughput

0.489

High

904439

CP2J2
Cytochrome P450 2J2

1

1

High-throughput

0.489

High

1250423

KSR2
Kinase suppressor of Ras 2

1

7

High-throughput

0.489

High

1390348

I17RA
Interleukin-17 receptor A

1

1

High-throughput

0.489

High

1420002

HAOX2
2-Hydroxyacid oxidase 2

1

1

High-throughput

0.489

High

1420009

CCL26
C-C motif chemokine 26

1

1

High-throughput

0.489

High

1420012

CCDC9
Coiled-coil domain-containing protein 9

1

1

High-throughput

0.489

High

132765

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

9

Small-scale

0.479

High

173321

XPO1
Exportin-1

1

13

High-throughput

0.479

High

177711

SMAD7
Mothers against decapentaplegic homolog 7

1

4

Small-scale

0.479

High

225105

TLX3
T-cell leukemia homeobox protein 3

1

12

High-throughput

0.479

High

260417

BRD4
Bromodomain-containing protein 4

1

17

High-throughput

0.479

High

520633

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.479

High

533305

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.479

High

533364

THB
Thyroid hormone receptor beta

1

20

Small-scale

0.479

High

578540

BRAF
Serine/threonine-protein kinase B-raf

1

6

High-throughput

0.479

High

607080

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

634933

BCL3
B-cell lymphoma 3 protein

1

11

Small-scale

0.479

High

662495

GATA2
Endothelial transcription factor GATA-2

1

10

High-throughput

0.479

High

662648

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

10

High-throughput

0.479

High

681505

PSA3
Proteasome subunit alpha type-3

1

5

Small-scale

0.479

High

717981

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

9

High-throughput

0.479

High

789569

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

799459

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.479

High

851663

GATA4
Transcription factor GATA-4

1

10

High-throughput

0.479

High

851810

NKX21
Homeobox protein Nkx-2.1

1

12

High-throughput

0.479

High

872721

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

983965

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

Small-scale

0.479

High

1040916

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

1063598

GOGA2
Golgin subfamily A member 2

1

13

High-throughput

0.479

High

1087992

NFIA
Nuclear factor 1 A-type

1

16

High-throughput

0.479

High

1091152

FOXC1
Forkhead box protein C1

1

12

High-throughput

0.479

High

1100347

TIF1B
Transcription intermediary factor 1-beta

1

12

High-throughput

0.479

High

1104666

IKZF1
DNA-binding protein Ikaros

1

6

High-throughput

0.479

High

1107181

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

Small-scale

0.479

High

1115406

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

1229672

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1276751

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1329853

SIR6
NAD-dependent protein deacylase sirtuin-6

1

6

Small-scale

0.479

High

1351150

SP7
Transcription factor Sp7

1

11

High-throughput

0.479

High

1367207

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1368100

HDAC2
Histone deacetylase 2

1

20

High-throughput

0.479

High

1404746

RING2
E3 ubiquitin-protein ligase RING2

1

17

High-throughput

0.479

High

1419999

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1420000

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1420001

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

9

Small-scale

0.479

High

1420003

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1420005

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1420006

IKZF3
Zinc finger protein Aiolos

1

7

High-throughput

0.479

High

1420007

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

279485

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

1025951

NDP
Norrin

1

0

Small-scale

0.458

High

832799

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.445

High

1351644

TCP1L
T-complex protein 10A homolog 1

1

2

High-throughput

0.445

High

1402899

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.445

High

1404369

CDC5L
Cell division cycle 5-like protein

1

6

High-throughput

0.445

High

369274

ANT3
Antithrombin-III

1

4

High-throughput

0.437

High

412570

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

1332391

TTC29
Tetratricopeptide repeat protein 29

1

3

High-throughput

0.437

High

1403337

RUFY1
RUN and FYVE domain-containing protein 1

1

12

High-throughput

0.437

High

1420010

NINL
Ninein-like protein

1

14

High-throughput

0.437

High

1236075

LIN54
Protein lin-54 homolog

1

0

Small-scale

0.426

High

1420004

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

5

High-throughput

0.407

High

1144794

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

0

High-throughput

0.347

High


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Last updated: 11Aug2025