HitPredict

Interactor 1: PSME4 (Q14997)
Proteasome activator complex subunit 4 (Proteasome activator PA200)
Gene: PSME4

Interactor 2: PSB7 (Q99436)
Proteasome subunit beta type-7 (EC 3.4.25.1) (Macropain chain Z) (Multicatalytic endopeptidase complex chain Z) (Proteasome subunit Z)
Gene: PSMB7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 28514442, 33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	BLM10_mid~Proteasome, DUF3437~Proteasome
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1843 Hs			1 277
+	Hs
		656228 PSME4_HUMAN (1-1843): 0: 2463: 100.00		PSA5_HUMAN (13-240): 3.35e-81: 246: 18.67
+	Hs
		656062 PSME4_HUMAN (1-1843): 0: 2463: 100.00		PSB8_HUMAN (31-243): 3.86e-78: 239: 24.30
+	Hs
		656600 PSME4_HUMAN (1-1843): 0: 2463: 100.00		PSB6_HUMAN (41-229): 3.57e-76: 233: 31.58
+	Hs
		656716 PSME4_HUMAN (1-1843): 0: 2463: 100.00		PSB5_HUMAN (42-243): 1.28e-74: 230: 26.11
+	Hs
		656115 PSME4_HUMAN (1-1843): 0: 2463: 100.00		PSB9_HUMAN (42-227): 9.71e-21: 89.7: 29.41
+	Sc
		625943 BLM10_YEAST (74-831): 0: 722: 16.61		PSB2_YEAST (11-272): 6.97e-82: 248: 54.92
+	Sc
		689188 BLM10_YEAST (74-831): 0: 722: 16.61		PSA5_YEAST (13-253): 6.07e-77: 236: 20.62
+	Sc
		675424 BLM10_YEAST (74-831): 0: 722: 16.61		PSB5_YEAST (5-246): 1.85e-70: 220: 22.54
+	Sc
		751170 BLM10_YEAST (74-831): 0: 722: 16.61		PSB1_YEAST (43-222): 1.62e-26: 104: 32.04