HitPredict

Interactor 1: PSMD6 (Q15008)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)
Gene: PSMD6

Interactor 2: DDI2 (Q5TDH0)
Protein DDI1 homolog 2 (EC 3.4.23.-)
Gene: DDI2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27114451
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RPN7~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 389 Hs			1 399
+	Hs
		1062848 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		DDI1_HUMAN (1-392): 7.44e-148: 426: 70.75
+	Hs
		121791 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		DDI2_HUMAN (1-399): 1.67e-162: 463: 100.00
+	Hs
		121821 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		DDI1_HUMAN (1-392): 7.44e-148: 426: 70.75
+	Hs
		1062897 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80
+	Hs
		1062891 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20
+	Hs
		1062884 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		UBQL4_HUMAN (8-241): 1.8e-44: 164: 14.59
+	Dm
		1358537 PSMD6_DROME (1-389): 2.36e-125: 368: 70.18		Q9VWD9_DROME (5-241): 8.99e-44: 161: 16.39
+	Hs
		872158 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00
+	Hs
		923997 PSMD6_HUMAN (1-389): 5.58e-137: 397: 100.00		RS27A_HUMAN (10-77): 3.2e-14: 71.7: 22.06
+	Hs
		121871 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80
+	Hs
		121867 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20
+	Hs
		888457 EIF3E_HUMAN (26-387): 7.71e-74: 238: 14.04		UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20
+	Hs
		121863 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		UBQL4_HUMAN (8-241): 1.8e-44: 164: 14.59
+	Dm
		1180727 PSD11_DROME (7-387): 4.3e-77: 246: 13.32		Q9VWD9_DROME (5-241): 8.99e-44: 161: 16.39
+	Sc
		697117 RPN7_YEAST (11-389): 3.41e-86: 269: 35.47		RAD23_YEAST (5-202): 3.88e-26: 110: 16.00
+	Hs
		121714 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00
+	Hs
		121730 PSD11_HUMAN (3-387): 8.54e-77: 245: 11.03		RS27A_HUMAN (10-77): 3.2e-14: 71.7: 22.06
+	Sc
		697128 RPN6_YEAST (30-389): 1.53e-56: 192: 12.57		RAD23_YEAST (5-202): 3.88e-26: 110: 16.00