Protein: ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl-coenzyme A thioester hydrolase 2a) (CTE-Ia) (Long-chain acyl-CoA thioesterase 2) (ZAP128)

Gene: ACOT2
Organism: Homo sapiens
Interactions: 129
UniProt ID: P49753

Gene Ontology (top 5):
GO:0000038 - very long-chain fatty acid metabolic process
GO:0001676 - long-chain fatty acid metabolic process
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005782 - peroxisomal matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

888720

ACOT1
Acyl-coenzyme A thioesterase 1

2

1

High-throughput

0.811

High

888739

SPT33
Spermatogenesis-associated protein 33

2

0

High-throughput

0.602

High

888697

TFAM
Transcription factor A, mitochondrial

2

1

High-throughput

0.601

High

279702

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

348422

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

1

High-throughput

0.584

High

888702

GRSF1
G-rich sequence factor 1

2

1

High-throughput

0.584

High

888764

SFXN1
Sideroflexin-1

2

1

High-throughput

0.584

High

888742

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.536

High

888722

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

483540

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

1

High-throughput

0.489

High

61455

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

66163

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

1

High-throughput

0.479

High

183610

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.479

High

281916

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287258

RF1M
Peptide chain release factor 1, mitochondrial

1

5

High-throughput

0.479

High

296213

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

350818

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

1

High-throughput

0.479

High

361616

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.479

High

411580

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

470925

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

519079

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

532454

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

710792

EPHB2
Ephrin type-B receptor 2

1

5

High-throughput

0.479

High

786027

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

828709

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

841655

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

851846

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

856220

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

882594

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

888696

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

888698

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

888699

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

888700

QOR
Quinone oxidoreductase

1

1

High-throughput

0.479

High

888701

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

888703

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

888705

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

888706

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

888707

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

7

High-throughput

0.479

High

888708

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

888710

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

888712

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

888713

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

888714

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.479

High

888715

CH082
UPF0598 protein C8orf82

1

1

High-throughput

0.479

High

888717

COX15
Heme A synthase COX15

1

1

High-throughput

0.479

High

888718

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.479

High

888719

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

7

High-throughput

0.479

High

888725

MCU
Calcium uniporter protein, mitochondrial

1

3

High-throughput

0.479

High

888728

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

3

High-throughput

0.479

High

888729

FAKD4
FAST kinase domain-containing protein 4

1

7

High-throughput

0.479

High

888731

MCUR1
Mitochondrial calcium uniporter regulator 1

1

3

High-throughput

0.479

High

888732

CHCH1
Small ribosomal subunit protein mS37

1

1

High-throughput

0.479

High

888733

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

3

High-throughput

0.479

High

888734

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.479

High

888735

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

888736

MTEF3
Transcription termination factor 3, mitochondrial

1

2

High-throughput

0.479

High

888737

RCC1L
RCC1-like G exchanging factor-like protein

1

1

High-throughput

0.479

High

888740

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

888741

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.479

High

888745

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

888746

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

888748

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.479

High

888750

TR61B
tRNA

1

1

High-throughput

0.479

High

888751

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

888752

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

888755

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

888756

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

3

High-throughput

0.479

High

888757

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.479

High

888758

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

1

High-throughput

0.479

High

888759

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

888760

MTRFR
Mitochondrial translation release factor in rescue

1

5

High-throughput

0.479

High

888761

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

888762

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

888763

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

888765

NGRN
Neugrin

1

1

High-throughput

0.479

High

888770

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

888771

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

3

High-throughput

0.479

High

888773

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

888774

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

7

High-throughput

0.479

High

888777

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

888778

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

5

High-throughput

0.479

High

888780

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

600490

ZNF3
Zinc finger protein 3

1

2

High-throughput

0.470

High

216643

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

292097

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

888692

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

888694

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

888695

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

888723

SNX32
Sorting nexin-32

1

0

High-throughput

0.458

High

888743

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

888744

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

888747

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

888753

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.458

High

888772

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

888776

MTCH1
Mitochondrial carrier homolog 1

1

0

High-throughput

0.458

High

653194

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

888738

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

1

High-throughput

0.445

High

465457

IGF1R
Insulin-like growth factor 1 receptor

1

10

High-throughput

0.437

High

650088

FGFR3
Fibroblast growth factor receptor 3

1

9

High-throughput

0.437

High

710684

EPHA8
Ephrin type-A receptor 8

1

4

High-throughput

0.437

High

888690

EPHA5
Ephrin type-A receptor 5

1

5

High-throughput

0.437

High

888691

EPHA4
Ephrin type-A receptor 4

1

6

High-throughput

0.437

High

888709

EPHA7
Ephrin type-A receptor 7

1

4

High-throughput

0.437

High

888711

NTRK3
NT-3 growth factor receptor

1

5

High-throughput

0.437

High

888716

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

125316

LEG9
Galectin-9

1

0

High-throughput

0.426

High

142304

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.426

High

326882

ARK73
Aldo-keto reductase family 7 member A3

1

0

High-throughput

0.426

High

888693

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

0

High-throughput

0.426

High

888704

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

888730

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.426

High

888769

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

888779

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

888689

PEX5
Peroxisomal targeting signal 1 receptor

1

2

Small-scale

0.408

High

628611

CAP7
Azurocidin

1

1

High-throughput

0.407

High

888721

RBM23
Probable RNA-binding protein 23

2

0

High-throughput

0.318

High

888775

NLGN3
Neuroligin-3

1

0

Small-scale

0.299

High

888768

ZN277
Zinc finger protein 277

1

0

High-throughput

0.269

Low

888754

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

888749

WDR18
WD repeat-containing protein 18

1

0

High-throughput

0.249

Low

330077

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

598705

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

689809

CD27
CD27 antigen

1

0

High-throughput

0.232

Low

888724

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.232

Low

888726

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

0

High-throughput

0.232

Low

888727

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.232

Low

888766

ZN331
Zinc finger protein 331

1

0

High-throughput

0.232

Low

888767

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low

888781

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025