HitPredict

Interactor 1: SART3 (Q15020)
Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)
Gene: SART3

Interactor 2: LSM4 (Q9Y4Z0)
U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)
Gene: LSM4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.925

Property	Details
Experiments	29395067, 33961781, 28514442, 27173435, 19615732
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LSM~Lsm_interact
Common GO terms	GO:0000387 - spliceosomal snRNP assembly GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0017070 - U6 snRNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 963 Hs			1 139
+	Hs
		1063313 SART3_HUMAN (1-963): 0: 638: 100.00		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Hs
		912638 SART3_HUMAN (1-963): 0: 638: 100.00		SMD3_HUMAN (2-108): 2.51e-28: 102: 30.84
+	Hs
		911838 SART3_HUMAN (1-963): 0: 638: 100.00		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82
+	Ce
		1088921 SART3_CAEEL (73-962): 3.23e-124: 399: 24.26		LSM4_CAEEL (1-82): 2.08e-36: 122: 75.61
+	Ce
		1088762 SART3_CAEEL (73-962): 3.23e-124: 399: 24.26		SMD3_CAEEL (2-124): 3.32e-33: 115: 30.23
+	Ce
		1013433 SART3_CAEEL (73-962): 3.23e-124: 399: 24.26		SMD1_CAEEL (1-88): 8.41e-30: 106: 25.84
+	Ce
		712466 SART3_CAEEL (73-962): 3.23e-124: 399: 24.26		RUXF_CAEEL (3-80): 1.17e-27: 99.3: 25.64
+	Hs
		1318167 CRNL1_HUMAN (36-683): 9.67e-110: 360: 14.35		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Hs
		911958 CRNL1_HUMAN (36-683): 9.67e-110: 360: 14.35		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82
+	Hs
		300299 PRP6_HUMAN (20-640): 4.55e-83: 290: 13.10		LSM4_HUMAN (1-139): 4.8e-47: 150: 100.00
+	Hs
		300294 PRP6_HUMAN (20-640): 4.55e-83: 290: 13.10		LSM2_HUMAN (1-94): 2.68e-36: 121: 28.42
+	Hs
		300104 PRP6_HUMAN (20-640): 4.55e-83: 290: 13.10		SMD3_HUMAN (2-108): 2.51e-28: 102: 30.84
+	Hs
		300099 PRP6_HUMAN (20-640): 4.55e-83: 290: 13.10		RUXF_HUMAN (3-70): 3.59e-27: 98.2: 33.82
+	Sc
		970252 CLF1_YEAST (48-658): 1.77e-74: 260: 13.68		SMD1_YEAST (1-120): 8.22e-33: 114: 20.55
+	Sc
		746365 CLF1_YEAST (48-658): 1.77e-74: 260: 13.68		LSM2_YEAST (1-88): 3.45e-32: 111: 28.09
+	Sc
		795434 CLF1_YEAST (48-658): 1.77e-74: 260: 13.68		SMD3_YEAST (2-102): 4.51e-28: 100: 33.66
+	Sc
		763246 PRP39_YEAST (130-596): 1.57e-67: 239: 13.25		SMD1_YEAST (1-120): 8.22e-33: 114: 20.55
+	Hs
		641701 U2AF2_HUMAN (620-894): 8.59e-67: 233: 23.36		SMD1_HUMAN (1-94): 4.78e-32: 111: 25.26
+	Sc
		763234 PRP39_YEAST (130-596): 1.57e-67: 239: 13.25		SMD3_YEAST (2-102): 4.51e-28: 100: 33.66
+	Zm
		8170 A0A1D6ELI3_MAIZE (697-948): 2.22e-55: 207: 25.28		B6UER1_MAIZE (1-92): 4.82e-36: 120: 30.11