Protein: MYH11
Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)

Gene: MYH11
Organism: Homo sapiens
Interactions: 136
UniProt ID: P35749

Gene Ontology (top 5):
GO:0000146 - microfilament motor activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

772647

MYH9
Myosin-9

3

18

High-throughput

0.827

High

773112

MYH10
Myosin-10

3

17

High-throughput

0.827

High

776829

MYH14
Myosin-14

2

16

High-throughput

0.754

High

169066

ML12B
Myosin regulatory light chain 12B

2

20

Small-scale

0.737

High

776793

ARP3
Actin-related protein 3

1

16

High-throughput

0.691

High

776792

MYL6
Myosin light polypeptide 6

3

19

High-throughput

0.667

High

776838

OVCA2
Esterase OVCA2

3

0

High-throughput

0.638

High

776865

CING
Cingulin

1

16

High-throughput

0.618

High

618655

ML12A
Myosin regulatory light chain 12A

1

20

High-throughput

0.618

High

776815

TNIP1
TNFAIP3-interacting protein 1

2

16

High-throughput

0.611

High

248382

GDF9
Growth/differentiation factor 9

2

0

High-throughput

0.602

High

563330

CFTR
Cystic fibrosis transmembrane conductance regulator

2

12

High-throughput

0.601

High

568125

PLSL
Plastin-2

1

15

High-throughput

0.575

High

776802

EM55
55 kDa erythrocyte membrane protein

2

1

High-throughput

0.574

High

776800

1433Z
14-3-3 protein zeta/delta

2

17

High-throughput

0.571

High

668521

APC
Adenomatous polyposis coli protein

1

8

High-throughput

0.541

High

776799

GRB2
Growth factor receptor-bound protein 2

1

9

High-throughput

0.541

High

135527

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

177811

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

High-throughput

0.536

High

192691

ARPC5
Actin-related protein 2/3 complex subunit 5

1

2

High-throughput

0.536

High

336363

SVIL
Supervillin

1

5

High-throughput

0.536

High

361145

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

637375

FLNA
Filamin-A

1

12

High-throughput

0.536

High

639198

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

High-throughput

0.536

High

776786

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

776788

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

776794

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.536

High

776798

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

High-throughput

0.536

High

776801

UBX2A
UBX domain-containing protein 2A

1

2

High-throughput

0.536

High

776805

1433F
14-3-3 protein eta

1

17

High-throughput

0.536

High

776807

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.536

High

776809

TRAF2
TNF receptor-associated factor 2

1

7

High-throughput

0.536

High

776813

BMPR2
Bone morphogenetic protein receptor type-2

1

1

High-throughput

0.536

High

776818

RBP1
RalA-binding protein 1

1

3

High-throughput

0.536

High

776833

POC1A
POC1 centriolar protein homolog A

1

5

High-throughput

0.536

High

776841

LRC59
Leucine-rich repeat-containing protein 59

1

5

High-throughput

0.536

High

776850

PARK7
Parkinson disease protein 7

1

2

High-throughput

0.536

High

776852

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

2

High-throughput

0.536

High

776870

AURKC
Aurora kinase C

1

15

High-throughput

0.536

High

776868

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.518

High

776872

SMC3
Structural maintenance of chromosomes protein 3

1

13

High-throughput

0.515

High

640786

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

0

High-throughput

0.513

High

776834

PLBL2
Putative phospholipase B-like 2

1

0

High-throughput

0.513

High

776836

GNPI2
Glucosamine-6-phosphate deaminase 2

1

0

High-throughput

0.513

High

303075

ZFAN5
AN1-type zinc finger protein 5

1

0

High-throughput

0.493

High

470884

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.489

High

773808

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

776819

INF2
Inverted formin-2

1

2

High-throughput

0.489

High

776846

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.489

High

136840

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

5

High-throughput

0.479

High

157026

CTRO
Citron Rho-interacting kinase

1

20

High-throughput

0.479

High

240137

FGF17
Fibroblast growth factor 17

1

1

High-throughput

0.479

High

240920

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

256789

H2B1K
Histone H2B type 1-K

1

11

High-throughput

0.479

High

277580

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.479

High

330712

KI20A
Kinesin-like protein KIF20A

1

13

High-throughput

0.479

High

400392

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

445760

ENOA
Alpha-enolase

1

5

High-throughput

0.479

High

464846

SP1
Transcription factor Sp1

1

5

Small-scale

0.479

High

468132

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

488420

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

6

Small-scale

0.479

High

690788

1433T
14-3-3 protein theta

1

17

High-throughput

0.479

High

711258

SHC1
SHC-transforming protein 1

1

12

High-throughput

0.479

High

730420

1433S
14-3-3 protein sigma

1

17

Small-scale

0.479

High

776787

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

776789

PPP5
Serine/threonine-protein phosphatase 5

1

12

High-throughput

0.479

High

776796

H4
Histone H4

1

4

High-throughput

0.479

High

776797

H2B1C
Histone H2B type 1-C/E/F/G/I

1

11

High-throughput

0.479

High

776804

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.479

High

776806

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.479

High

776808

TFCP2
Alpha-globin transcription factor CP2

1

3

High-throughput

0.479

High

776811

TCOF
Treacle protein

1

7

High-throughput

0.479

High

776812

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

13

High-throughput

0.479

High

776816

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

776817

EEA1
Early endosome antigen 1

1

17

High-throughput

0.479

High

776821

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

776822

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

776823

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

776827

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

12

High-throughput

0.479

High

776830

SLN11
Schlafen family member 11

1

5

Small-scale

0.479

High

776835

FBX25
F-box only protein 25

1

8

High-throughput

0.479

High

776837

ASB11
Ankyrin repeat and SOCS box protein 11

1

5

High-throughput

0.479

High

776840

H2A1C
Histone H2A type 1-C

1

1

High-throughput

0.479

High

776842

CHM4C
Charged multivesicular body protein 4c

1

5

High-throughput

0.479

High

776844

SPDLY
Protein Spindly

1

17

High-throughput

0.479

High

776845

AURKB
Aurora kinase B

1

15

High-throughput

0.479

High

776847

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

776855

SIK2
Serine/threonine-protein kinase SIK2

1

11

Small-scale

0.479

High

776856

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

776857

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.479

High

776859

ECT2
Protein ECT2

1

8

High-throughput

0.479

High

776861

ANLN
Anillin

1

5

High-throughput

0.479

High

776862

ATD3A
ATPase family AAA domain-containing protein 3A

1

3

High-throughput

0.479

High

776866

WRP73
WD repeat-containing protein WRAP73

1

2

High-throughput

0.479

High

776867

HDAC6
Protein deacetylase HDAC6

1

13

High-throughput

0.479

High

321451

PRP6
Pre-mRNA-processing factor 6

1

0

High-throughput

0.458

High

533608

CLUS
Clusterin

1

0

High-throughput

0.458

High

776795

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

776851

MYOC
Myocilin

1

0

Small-scale

0.458

High

776858

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.458

High

776863

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.458

High

686787

S10A4
Protein S100-A4

1

15

High-throughput

0.445

High

776790

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

10

High-throughput

0.445

High

776810

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

1

High-throughput

0.445

High

776849

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

4

High-throughput

0.445

High

353049

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.437

High

371334

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

588059

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

694773

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

767554

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

776826

LRC31
Leucine-rich repeat-containing protein 31

1

5

High-throughput

0.437

High

776843

TBC31
TBC1 domain family member 31

1

5

High-throughput

0.437

High

776848

RHOV
Rho-related GTP-binding protein RhoV

1

5

High-throughput

0.437

High

776854

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.437

High

776869

WDR3
WD repeat-containing protein 3

1

8

High-throughput

0.437

High

776871

SCN8A
Sodium channel protein type 8 subunit alpha

1

8

High-throughput

0.437

High

776874

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.437

High

95915

E7ERK7
TBC1 domain family member 31

1

4

High-throughput

0.407

High

429415

JUN
Transcription factor Jun

1

4

High-throughput

0.407

High

776803

TF2B
Transcription initiation factor IIB

1

1

Small-scale

0.407

High

776832

SLX4
Structure-specific endonuclease subunit SLX4

1

7

High-throughput

0.407

High

776791

RWD2B
RWD domain-containing protein 2B

3

0

High-throughput

0.347

High

399497

C4BPA
C4b-binding protein alpha chain

1

0

High-throughput

0.279

Low

776820

ASTE1
Single-strand DNA endonuclease ASTE1

1

0

High-throughput

0.279

Low

776828

COX15
Heme A synthase COX15

1

0

High-throughput

0.279

Low

776853

SLX1
Structure-specific endonuclease subunit SLX1

1

0

High-throughput

0.279

Low

776860

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

776873

SL9A8
Sodium/hydrogen exchanger 8

1

0

High-throughput

0.279

Low

63816

PEDS1
Plasmanylethanolamine desaturase 1

1

0

High-throughput

0.249

Low

776814

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

776824

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.249

Low

776825

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

776831

ZN227
Zinc finger protein 227

1

0

High-throughput

0.249

Low

776839

SBP2L
Selenocysteine insertion sequence-binding protein 2-like

1

0

High-throughput

0.249

Low

776864

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

598540

UD2B7
UDP-glucuronosyltransferase 2B7

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025