HitPredict

Interactor 1: U5S1 (Q15029)
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)
Gene: EFTUD2

Interactor 2: DDX23 (Q9BUQ8)
Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD)
Gene: DDX23

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	26186194, 28514442, 34079125, 28515276, 33961781, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046540 - U4/U6 x U5 tri-snRNP complex and 1 others more... GO:0071013 - catalytic step 2 spliceosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 972 Hs			1 820
+	Ce
		1095364 Q23463_CAEEL (1-964): 0: 973: 69.94		Q65XX1_CAEEL (374-800): 4.28e-171: 511: 36.24
+	Ce
		1095365 Q23463_CAEEL (1-964): 0: 973: 69.94		Q95XY1_CAEEL (374-800): 2.56e-171: 511: 36.24
+	Hs
		1064551 U5S1_HUMAN (1-972): 0: 1062: 100.00		DDX17_HUMAN (337-820): 5.87e-132: 412: 34.97
+	Hs
		134052 U5S1_HUMAN (1-972): 0: 1062: 100.00		DDX3X_HUMAN (236-804): 2.78e-130: 405: 30.65
+	Hs
		571462 U5S1_HUMAN (1-972): 0: 1062: 100.00		DDX5_HUMAN (297-801): 3.08e-129: 401: 32.81
+	Ce
		1095368 Q23463_CAEEL (1-964): 0: 973: 69.94		Q9N3F4_CAEEL (355-800): 4.37e-153: 463: 34.51
+	Hs
		1064818 U5S1_HUMAN (1-972): 0: 1062: 100.00		DDX41_HUMAN (365-795): 7.12e-81: 273: 39.32
+	Sc
		616108 SN114_YEAST (3-967): 0: 692: 32.82		PRP28_YEAST (200-785): 4.88e-170: 505: 35.56