Protein: MCA1
Metacaspase-1 (EC 3.4.22.-) [Cleaved into: Large subunit p20; Small subunit p10]

Gene: MCA1
Organism: Saccharomyces cerevisiae S288C
Interactions: 177
UniProt ID: Q08601

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1064511

MCA1
Metacaspase-1

2

4

Small-scale

0.778

High

865905

BIR1
Chromosomal passenger complex protein BIR1

2

0

Small-scale

0.738

High

1055181

PIN3
[PSI+] inducibility protein 3

3

2

High-throughput

0.669

High

919309

LSB1
LAS seventeen-binding protein 1

3

2

High-throughput

0.658

High

546567

SSB1
Ribosome-associated molecular chaperone SSB1

3

1

Small-scale

0.633

High

819998

SSB2
Ribosome-associated molecular chaperone SSB2

3

1

Small-scale

0.633

High

671201

SIS1
Protein SIS1

2

1

Small-scale

0.624

High

444643

DED1
ATP-dependent RNA helicase DED1

2

1

Small-scale

0.611

High

580187

HSC82
ATP-dependent molecular chaperone HSC82

2

2

Small-scale

0.611

High

680123

CDC48
Cell division control protein 48

2

1

Small-scale

0.611

High

747614

RSSA1
Small ribosomal subunit protein uS2A

2

1

Small-scale

0.611

High

394965

EF1A
Elongation factor 1-alpha

2

0

Small-scale

0.585

High

427465

RLA0
Large ribosomal subunit protein uL10

2

0

Small-scale

0.585

High

435408

RS3
Small ribosomal subunit protein uS3

2

0

Small-scale

0.585

High

676427

MAS5
Mitochondrial protein import protein MAS5

2

0

Small-scale

0.585

High

828327

MKT1
Post-transcriptional regulator MKT1

2

0

Small-scale

0.585

High

1064515

HSP42
Heat shock protein 42

2

0

Small-scale

0.585

High

525394

HSP71
Heat shock protein SSA1

2

1

Small-scale

0.584

High

527886

HSP72
Heat shock protein SSA2

2

1

Small-scale

0.584

High

858296

ARC1
tRNA-aminoacylation cofactor ARC1

2

0

High-throughput

0.576

High

1064512

SGT2
Small glutamine-rich tetratricopeptide repeat-containing protein 2

2

0

Small-scale

0.569

High

794699

SRO77
Lethal(2) giant larvae protein homolog SRO77

2

0

High-throughput

0.565

High

449191

CALM
Calmodulin

1

0

Small-scale

0.537

High

393462

HSP82
ATP-dependent molecular chaperone HSP82

1

2

Small-scale

0.536

High

734221

EF2
Elongation factor 2

1

1

Small-scale

0.536

High

638740

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

0

Small-scale

0.513

High

684865

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.513

High

792286

GBLP
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.513

High

436541

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.501

High

408493

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

806376

KOG1
Target of rapamycin complex 1 subunit KOG1

1

1

High-throughput

0.481

High

623966

MYO2
Myosin-2

1

0

Small-scale

0.480

High

801143

NSE2
E3 SUMO-protein ligase MMS21

1

0

Small-scale

0.480

High

818429

DDI1
DNA damage-inducible protein 1

1

0

Small-scale

0.480

High

836353

BNI1
Protein BNI1

1

0

High-throughput

0.480

High

874286

MON2
Protein MON2

1

0

Small-scale

0.480

High

367137

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

367821

ENO1
Enolase 1

1

1

High-throughput

0.479

High

368076

ENO2
Enolase 2

1

1

High-throughput

0.479

High

445374

CDC31
Cell division control protein 31

1

1

High-throughput

0.479

High

486339

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.479

High

486524

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.479

High

509747

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

518411

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.479

High

531914

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.479

High

592546

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.479

High

598927

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

High-throughput

0.479

High

599086

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.479

High

626909

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.479

High

738613

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.479

High

755187

GCN1
eIF-2-alpha kinase activator GCN1

1

1

High-throughput

0.479

High

763505

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.479

High

802776

RRP3
ATP-dependent rRNA helicase RRP3

1

2

High-throughput

0.479

High

803173

ECM29
Proteasome component ECM29

1

1

High-throughput

0.479

High

812128

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

816010

VAC8
Vacuolar protein 8

1

1

High-throughput

0.479

High

836933

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.479

High

885106

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.479

High

1028038

ACAC
Acetyl-CoA carboxylase

1

2

High-throughput

0.479

High

762875

TOR1
Serine/threonine-protein kinase TOR1

1

0

High-throughput

0.460

High

358358

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.458

High

359538

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

0

High-throughput

0.458

High

365211

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

368926

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

386892

TBB
Tubulin beta chain

1

0

High-throughput

0.458

High

416161

SYTC
Threonine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

442147

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

446252

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.458

High

450656

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.458

High

452536

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.458

High

453831

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.458

High

459176

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.458

High

470214

NUC1
Mitochondrial nuclease

1

0

High-throughput

0.458

High

471444

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.458

High

510874

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.458

High

513585

RL1A
Large ribosomal subunit protein uL1A

1

0

High-throughput

0.458

High

534319

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

0

High-throughput

0.458

High

553664

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.458

High

554740

YPK1
Serine/threonine-protein kinase YPK1

1

0

High-throughput

0.458

High

570169

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

572659

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

576999

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.458

High

597998

NCPR
NADPH--cytochrome P450 reductase

1

0

High-throughput

0.458

High

618626

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.458

High

621412

METK2
S-adenosylmethionine synthase 2

1

0

High-throughput

0.458

High

639084

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.458

High

644851

CLH
Clathrin heavy chain

1

0

High-throughput

0.458

High

655526

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.458

High

661831

TOM40
Mitochondrial import receptor subunit TOM40

1

0

High-throughput

0.458

High

666562

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.458

High

672735

BPH1
Beige protein homolog 1

1

0

High-throughput

0.458

High

673131

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.458

High

688955

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

694662

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

701742

URA7
CTP synthase 1

1

0

High-throughput

0.458

High

708402

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

721425

MCM4
DNA replication licensing factor MCM4

1

0

High-throughput

0.458

High

733684

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

735204

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

744544

DRI1
Putative RNA-binding protein involved in heterochromatin assembly

1

0

High-throughput

0.458

High

750793

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

762896

TREB
Probable trehalase

1

0

High-throughput

0.458

High

805365

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

High-throughput

0.458

High

813757

FLC2
Flavin carrier protein 2

1

0

High-throughput

0.458

High

815596

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.458

High

815757

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

817972

IMB4
Importin subunit beta-4

1

0

High-throughput

0.458

High

843152

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

0

High-throughput

0.458

High

849932

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.458

High

850496

LSB3
LAS seventeen-binding protein 3

1

0

High-throughput

0.458

High

858138

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

865094

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.458

High

865652

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

868457

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

918708

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

919529

AP18B
Clathrin coat assembly protein AP180B

1

0

High-throughput

0.458

High

923217

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.458

High

948679

ACT
Actin

1

0

High-throughput

0.458

High

1031067

NOP3
Serine/arginine

1

0

High-throughput

0.458

High

1039059

IMA1
Importin subunit alpha

1

0

High-throughput

0.458

High

1043602

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.458

High

1044490

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

1047507

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.458

High

1056574

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

1060647

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.458

High

1063934

ETT1
Enhancer of translation termination 1

1

0

High-throughput

0.458

High

1064514

RPN5
26S proteasome regulatory subunit RPN5

1

0

High-throughput

0.458

High

1064517

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.458

High

1064518

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

744629

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

High-throughput

0.438

High

780652

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.438

High

368200

THDH
Threonine dehydratase, mitochondrial

1

1

High-throughput

0.437

High

597568

EF3A
Elongation factor 3A

1

1

High-throughput

0.437

High

603561

VATA
V-type proton ATPase catalytic subunit A

1

2

High-throughput

0.437

High

673537

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

1

High-throughput

0.437

High

701570

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

1

High-throughput

0.437

High

736146

ARP2
Actin-related protein 2

1

1

High-throughput

0.437

High

744403

ATC5
Phospholipid-transporting ATPase DNF1

1

1

High-throughput

0.437

High

825487

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

865593

ARP3
Actin-related protein 3

1

1

High-throughput

0.437

High

1064516

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.437

High

1064519

ATC4
Phospholipid-transporting ATPase DNF2

1

1

High-throughput

0.437

High

836113

COPB2
Coatomer subunit beta'

2

0

Small-scale

0.318

High

820362

YNU8
Uncharacterized protein YNL208W

2

0

High-throughput

0.305

High

438499

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

Small-scale

0.279

Low

825683

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.279

Low

836032

COPB
Coatomer subunit beta

1

0

Small-scale

0.279

Low

453219

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

High-throughput

0.249

Low

456461

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

464519

CHS1
Chitin synthase 1

1

0

High-throughput

0.249

Low

575531

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.249

Low

585399

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.249

Low

645278

GAS1
1,3-beta-glucanosyltransferase GAS1

1

0

High-throughput

0.249

Low

661698

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

662705

EXG1
Glucan 1,3-beta-glucosidase I/II

1

0

High-throughput

0.249

Low

668965

ERG6
Sterol 24-C-methyltransferase ERG6

1

0

High-throughput

0.249

Low

672273

CDC10
Cell division control protein 10

1

0

High-throughput

0.249

Low

726122

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

0

High-throughput

0.249

Low

737994

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

High-throughput

0.249

Low

746471

SSO1
Protein SSO1

1

0

High-throughput

0.249

Low

748571

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

794948

YBI1
Uncharacterized protein YBL081W

1

0

High-throughput

0.249

Low

795247

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

796550

ECM33
Cell wall protein ECM33

1

0

High-throughput

0.249

Low

801115

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.249

Low

802055

HXT5
Probable glucose transporter HXT5

1

0

High-throughput

0.249

Low

810916

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.249

Low

816219

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.249

Low

818208

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

0

High-throughput

0.249

Low

850756

COPD
Coatomer subunit delta

1

0

High-throughput

0.249

Low

864905

VTC4
Vacuolar transporter chaperone complex subunit 4

1

0

High-throughput

0.249

Low

916433

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.249

Low

925393

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

1038599

PDR12
ATP-dependent permease PDR12

1

0

High-throughput

0.249

Low

1064513

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

470242

PT111
Protein PET111, mitochondrial

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025