HitPredict

Interactor 1: ARHG6 (Q15052)
Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Gene: ARHGEF6

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.945

The method score is based on:

Property Details
Experiments 10428811, 28514442, 32203420, 33961781, 21900206, unassigned2213
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ArfGap~PH, GIT_SHD~RhoGEF67_u2
Common GO terms GO:0005096 - GTPase activator activity
GO:0005829 - cytosol
GO:0030027 - lamellipodium
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 776
Hs

1 761
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024