HitPredict

Interactor 1: PDCD1 (Q15116)
Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
Gene: PDCD1

Interactor 2: PD1L2 (Q9BQ51)
Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)
Gene: PDCD1LG2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.884

Property	Details
Experiments	12893276, 23417675, 20587542
Identification Methods	pull down, surface plasmon resonance, nuclear magnetic resonance, isothermal titration calorimetry
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C2-set_2~V-set
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 288 Hs			1 273
+	Mm
		970112 PDCD1_MOUSE (1-288): 1.49e-179: 497: 59.31		PD1L1_MOUSE (2-268): 3.31e-61: 196: 34.25
+	Hs
		1067951 PDCD1_HUMAN (1-288): 0: 506: 100.00		PD1L1_HUMAN (21-269): 5.68e-55: 180: 35.77
+	Mm
		970114 PDCD1_MOUSE (1-288): 1.49e-179: 497: 59.31		PD1L2_MOUSE (13-247): 6.17e-52: 171: 70.64
+	Hs
		706897 PDCD1_HUMAN (1-288): 0: 506: 100.00		CD80_HUMAN (30-225): 3.03e-12: 67.1: 18.27