HitPredict

Interactor 1: PDK2 (Q15119)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)
Gene: PDK2

Interactor 2: PDK4 (Q16654)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)
Gene: PDK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains BCDHK_Adom3~HATPase_c, HATPase_c~HATPase_c
Common GO terms GO:0004672 - protein kinase activity
GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
and 7 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 407
Hs

1 411
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Last updated: 15 Jul 2024