HitPredict

Interactor 1: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Interactor 2: DOT1L (Q8TEK3)
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)
Gene: DOT1L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35850772
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 471 Hs			1 1537
+	Hs
		1031399 PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1256303 PSPC1_HUMAN (20-470): 2.17e-67: 226: 58.41		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		516603 PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		613529 SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1077425 ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1256371 RBM4_HUMAN (75-182): 7.64e-09: 59.3: 35.71		DOT1L_HUMAN (1-1537): 0: 2441: 100.00