Protein: PRS6B
26S proteasome regulatory subunit 6B homolog (Protein YNT1) (Tat-binding homolog 2)

Gene: PRS6B, RPT3
Organism: Saccharomyces cerevisiae S288C
Interactions: 186
UniProt ID: P33298

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

750858

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

26

20

Small-scale

0.990

High

750816

PRS7
26S proteasome regulatory subunit 7 homolog

16

20

Small-scale

0.985

High

750606

PRS6A
26S proteasome regulatory subunit 6A

13

18

Small-scale

0.982

High

750885

PRS8
26S proteasome regulatory subunit 8 homolog

12

19

Small-scale

0.979

High

750875

PRS10
26S proteasome subunit RPT4

10

19

Small-scale

0.973

High

750909

RPN5
26S proteasome regulatory subunit RPN5

8

20

Small-scale

0.968

High

750848

PRS4
26S proteasome regulatory subunit 4 homolog

7

19

Small-scale

0.960

High

743967

RAD23
UV excision repair protein RAD23

6

20

Small-scale

0.945

High

750859

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

6

12

High-throughput

0.945

High

750896

RPN7
26S proteasome regulatory subunit RPN7

5

20

High-throughput

0.925

High

750815

PRS6B
26S proteasome regulatory subunit 6B homolog

5

18

Small-scale

0.922

High

750904

RPN8
26S proteasome regulatory subunit RPN8

5

20

Small-scale

0.919

High

645147

PSB4
Proteasome subunit beta type-4

4

20

Small-scale

0.881

High

661488

PSA2
Proteasome subunit alpha type-2

4

20

Small-scale

0.873

High

750847

PSA4
Proteasome subunit alpha type-4

2

20

High-throughput

0.789

High

750867

PSD10
Probable 26S proteasome regulatory subunit p28

15

7

Small-scale

0.765

High

750839

RPN1
26S proteasome regulatory subunit RPN1

14

20

Small-scale

0.761

High

636646

PSA1
Proteasome subunit alpha type-1

2

20

High-throughput

0.754

High

750846

PSA6
Proteasome subunit alpha type-6

2

20

High-throughput

0.754

High

750840

RPN10
26S proteasome regulatory subunit RPN10

7

16

Small-scale

0.749

High

740129

RPN2
26S proteasome regulatory subunit RPN2

9

20

Small-scale

0.749

High

750831

HSM3
DNA mismatch repair protein HSM3

8

1

Small-scale

0.747

High

750911

RPN6
26S proteasome regulatory subunit RPN6

7

20

Small-scale

0.746

High

750872

RPN14
26S proteasome regulatory subunit RPN14

6

11

Small-scale

0.733

High

738291

RPN12
26S proteasome regulatory subunit RPN12

6

7

Small-scale

0.731

High

750893

RPN9
26S proteasome regulatory subunit RPN9

5

13

Small-scale

0.722

High

150278

RPN13
26S proteasome regulatory subunit RPN13

5

1

Small-scale

0.713

High

750851

PSMD9
Probable 26S proteasome regulatory subunit p27

5

8

Small-scale

0.709

High

750844

RPN3
26S proteasome regulatory subunit RPN3

5

12

Small-scale

0.706

High

744189

RAD24
Checkpoint protein RAD24

1

4

High-throughput

0.691

High

750834

RFC3
Replication factor C subunit 3

1

2

High-throughput

0.691

High

750849

RFC4
Replication factor C subunit 4

1

2

High-throughput

0.691

High

314859

SEM1
26S proteasome complex subunit SEM1

4

1

Small-scale

0.683

High

750864

DSK2
Ubiquitin domain-containing protein DSK2

1

20

Small-scale

0.681

High

750837

ECM29
Proteasome component ECM29

3

6

High-throughput

0.656

High

509471

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

449326

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

3

0

High-throughput

0.629

High

555243

RAD50
DNA repair protein RAD50

2

1

High-throughput

0.628

High

675321

RAD51
DNA repair protein RAD51

2

2

High-throughput

0.621

High

701681

URA7
CTP synthase 1

2

2

High-throughput

0.621

High

636559

PSA7
Probable proteasome subunit alpha type-7

1

20

High-throughput

0.618

High

661393

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.618

High

668377

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.618

High

675236

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

679529

CDC48
Cell division control protein 48

1

14

High-throughput

0.618

High

721246

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.618

High

721296

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

726891

HS104
Heat shock protein 104

1

4

High-throughput

0.618

High

735914

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.618

High

750833

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.618

High

392482

HSP82
ATP-dependent molecular chaperone HSP82

2

7

High-throughput

0.594

High

750913

RUVB2
RuvB-like protein 2

2

3

High-throughput

0.594

High

750829

CENPU
Inner kinetochore subunit AME1

2

0

Small-scale

0.594

High

750856

MPG1
Mannose-1-phosphate guanyltransferase

2

0

High-throughput

0.592

High

734643

IMB3
Importin subunit beta-3

2

3

High-throughput

0.588

High

750877

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

7

Small-scale

0.584

High

750817

SPT7
SAGA complex subunit SPT7

1

4

High-throughput

0.575

High

750886

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.575

High

523481

HSP71
Heat shock protein SSA1

2

7

High-throughput

0.552

High

750888

SKY1
Serine/threonine-protein kinase SKY1

1

7

Small-scale

0.541

High

368335

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

2

High-throughput

0.536

High

399359

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

5

High-throughput

0.536

High

417063

VDAC1
Non-selective voltage-gated ion channel 1

1

2

High-throughput

0.536

High

486440

TBA3
Tubulin alpha-3 chain

1

2

High-throughput

0.536

High

585608

STI1
Heat shock protein STI1

1

9

High-throughput

0.536

High

645902

DBF2
Cell cycle protein kinase DBF2

1

8

High-throughput

0.536

High

657073

IF5A1
Eukaryotic translation initiation factor 5A-1

1

2

High-throughput

0.536

High

736078

ARP2
Actin-related protein 2

1

3

High-throughput

0.536

High

739942

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

3

Small-scale

0.536

High

745440

KU70
ATP-dependent DNA helicase II subunit 1

1

1

High-throughput

0.536

High

750823

LHS1
Heat shock protein 70 homolog LHS1

1

8

High-throughput

0.536

High

750841

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.536

High

750868

UBC12
NEDD8-conjugating enzyme UBC12

1

4

High-throughput

0.536

High

750870

MSN5
Protein MSN5

1

2

High-throughput

0.536

High

750876

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

2

High-throughput

0.536

High

750884

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

5

High-throughput

0.536

High

750906

MDN1
Midasin

1

1

High-throughput

0.536

High

750915

SUS1
SAGA complex subunit SUS1

1

1

High-throughput

0.536

High

750889

ESC1
Silent chromatin protein ESC1

2

5

High-throughput

0.533

High

670526

SIS1
Protein SIS1

1

5

High-throughput

0.515

High

636922

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.513

High

750853

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

750874

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.513

High

750908

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.513

High

408403

GAL4
Regulatory protein GAL4

1

1

Small-scale

0.501

High

394405

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.500

High

453512

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.500

High

470498

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.500

High

592139

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.500

High

598988

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

3

High-throughput

0.500

High

633454

PP11
Serine/threonine-protein phosphatase PP1-1

1

4

High-throughput

0.500

High

637197

PWP1
Periodic tryptophan protein 1

1

13

High-throughput

0.500

High

675283

DMC1
Meiotic recombination protein DMC1

1

2

High-throughput

0.500

High

675858

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.500

High

750818

MDJ1
DnaJ homolog 1, mitochondrial

1

6

High-throughput

0.500

High

750827

IMB2
Importin subunit beta-2

1

3

High-throughput

0.500

High

750862

TCPQ
T-complex protein 1 subunit theta

1

10

High-throughput

0.500

High

750895

ERB1
Ribosome biogenesis protein ERB1

1

6

High-throughput

0.500

High

750902

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.500

High

701504

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

6

High-throughput

0.489

High

750855

COPB2
Coatomer subunit beta'

1

5

High-throughput

0.489

High

408309

GAL1
Galactokinase

1

0

High-throughput

0.479

High

531291

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

626674

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

750854

PAC11
WD repeat-containing protein PAC11

1

0

High-throughput

0.479

High

149671

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.479

High

364442

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.479

High

434965

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

435871

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

514548

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

558660

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

579114

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

603032

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.479

High

647070

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

649593

KCC2
Calcium/calmodulin-dependent protein kinase II

1

3

High-throughput

0.479

High

706639

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

708704

TF3B
Transcription factor IIIB 70 kDa subunit

1

3

High-throughput

0.479

High

738800

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

747777

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

750819

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

750820

SPT21
Protein SPT21

1

1

High-throughput

0.479

High

750821

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

750822

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.479

High

750825

TCD2
tRNA threonylcarbamoyladenosine dehydratase 2

1

2

High-throughput

0.479

High

750832

RCK2
Serine/threonine-protein kinase RCK2

1

4

High-throughput

0.479

High

750838

TCD1
tRNA threonylcarbamoyladenosine dehydratase 1

1

2

High-throughput

0.479

High

750842

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

750852

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

750861

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

750865

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

750866

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

750871

INO80
Chromatin-remodeling ATPase INO80

1

3

Small-scale

0.479

High

750878

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

750881

H3
Histone H3

1

7

High-throughput

0.479

High

750883

CDC14
Tyrosine-protein phosphatase CDC14

1

9

High-throughput

0.479

High

750887

RPN4
Protein RPN4

1

1

Small-scale

0.479

High

750891

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

750894

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

750898

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

750899

NAT3
N-terminal acetyltransferase B complex catalytic subunit NAT3

1

1

Small-scale

0.479

High

750907

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

750912

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.479

High

750914

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.479

High

633244

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

Small-scale

0.458

High

734911

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

750828

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

750860

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

750873

MCY1
Putative mitochondrial cysteine synthase

1

0

High-throughput

0.458

High

750892

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

750897

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

750900

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

750903

SGO1
Shugoshin

1

0

High-throughput

0.458

High

750910

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

405067

LEU3
3-isopropylmalate dehydrogenase

1

6

High-throughput

0.457

High

575324

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.457

High

673489

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

1

High-throughput

0.457

High

750824

VPS21
Vacuolar protein sorting-associated protein 21

1

1

High-throughput

0.457

High

750826

AP3M
AP-3 complex subunit mu

1

1

High-throughput

0.457

High

750890

WDR59
Maintenance of telomere capping protein 5

1

14

High-throughput

0.457

High

750901

SHS1
Seventh homolog of septin 1

1

2

High-throughput

0.457

High

440924

CDC7
Cell division control protein 7

1

17

Small-scale

0.445

High

510343

HSP77
Import motor subunit, mitochondrial

1

9

High-throughput

0.445

High

742809

HSP79
Heat shock protein homolog SSE2

1

9

High-throughput

0.445

High

750836

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.445

High

750843

HSP7E
Heat shock protein SSC3, mitochondrial

1

9

High-throughput

0.445

High

750845

SSB2
Ribosome-associated molecular chaperone SSB2

1

7

High-throughput

0.445

High

750863

DPH4
Diphthamide biosynthesis protein 4

1

2

High-throughput

0.445

High

433546

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

454966

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

504128

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

512346

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.437

High

689354

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.437

High

747260

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

750850

MLP2
Protein MLP2

1

5

High-throughput

0.437

High

750857

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

750882

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

750905

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.437

High

750869

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

750830

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

661714

VAN1
Mannan polymerase I complex VAN1 subunit

1

0

High-throughput

0.261

Low

677068

MGR1
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1

1

0

High-throughput

0.249

Low

750835

HXT5
Probable glucose transporter HXT5

1

0

High-throughput

0.249

Low

750879

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

456375

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.232

Low

750880

TMEDA
Endoplasmic reticulum vesicle protein 25

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025