HitPredict

Interactor 1: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Interactor 2: CXXC1 (Q9P0U4)
CXXC-type zinc finger protein 1 (CpG-binding protein) (PHD finger and CXXC domain-containing protein 1)
Gene: CXXC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.761

Property	Details
Experiments	19410543, 23870121, 26496610, 28514442, 33961781, 23508102, 19433449, 16253997, 18082152, 18680430, 31076518, 24981860, 37689310, 20305087
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 538 Hs			1 656
+	Hs
		903567 WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41		CXXC1_HUMAN (1-656): 0: 739: 100.00
+	Hs
		1070808 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2B_HUMAN (75-373): 1.02e-41: 165: 18.96
+	Hs
		975258 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79
+	Hs
		1070812 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KDM2A_HUMAN (95-344): 1.63e-29: 127: 18.27
+	Mm
		876680 RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07		KMT2A_MOUSE (74-359): 3.93e-29: 126: 18.63
+	Zm
		17586 A0A1D6JRL3_MAIZE (1-497): 8.51e-97: 306: 31.98		A0A1D6GXC6_MAIZE (22-109): 1.28e-18: 93: 28.09
+	Sp
		194053 SWD1_SCHPO (1-392): 1.06e-88: 280: 32.68		SPP1_SCHPO (19-108): 3.97e-26: 113: 33.33
+	Sc
		763537 SWD1_YEAST (1-356): 1.48e-77: 252: 30.08		SPP1_YEAST (10-111): 1.54e-23: 104: 25.00
+	Hs
		1281461 FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56		MBD1_HUMAN (27-356): 1.72e-46: 175: 21.56
+	Hs
		1288387 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		KMT2B_HUMAN (75-373): 1.02e-41: 165: 18.96
+	Hs
		975304 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79
+	Hs
		975303 FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56		KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79
+	Hs
		1288392 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		PHF8_HUMAN (10-152): 2.11e-29: 127: 23.38
+	Hs
		1288397 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		KDM2A_HUMAN (95-344): 1.63e-29: 127: 18.27
+	Dm
		1279320 EBI_DROME (179-518): 9.89e-30: 125: 10.98		JHD1_DROME (155-209): 4.75e-16: 84.5: 45.46
+	Hs
		903149 WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41		KMT2A_HUMAN (74-341): 2.38e-36: 148: 19.79
+	Hs
		1281353 FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56		DIDO1_HUMAN (3-159): 7.85e-28: 122: 24.85
+	Mm
		903667 WDR5_MOUSE (282-429): 2.1e-09: 61.2: 11.41		KDM2B_MOUSE (171-356): 4.13e-29: 126: 21.82
+	Hs
		641257 FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56		DNMT1_HUMAN (147-214): 1.3e-18: 92.7: 33.82
+	Hs
		641180 WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41		DNMT1_HUMAN (147-214): 1.3e-18: 92.7: 33.82