Protein: APC1
Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein)

Gene: APC1, ANAPC1
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q9H1A4

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005829 - cytosol
GO:0007091 - metaphase/anaphase transition of mitotic cell cycle
GO:0007346 - regulation of mitotic cell cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1328553

APC5
Anaphase-promoting complex subunit 5

4

1

Small-scale

0.875

High

672889

CDC27
Cell division cycle protein 27 homolog

14

8

Small-scale

0.757

High

1328554

APC4
Anaphase-promoting complex subunit 4

10

1

Small-scale

0.749

High

1017434

CDC20
Cell division cycle protein 20 homolog

9

10

Small-scale

0.744

High

1022981

CDC16
Cell division cycle protein 16 homolog

6

11

Small-scale

0.737

High

1328555

ANC2
Anaphase-promoting complex subunit 2

6

4

Small-scale

0.722

High

1328558

FZR1
Fizzy-related protein homolog

4

10

Small-scale

0.696

High

236978

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

4

2

Small-scale

0.691

High

1328551

CDC23
Cell division cycle protein 23 homolog

4

11

Small-scale

0.687

High

1328563

LMBL1
Lethal(3)malignant brain tumor-like protein 1

4

0

High-throughput

0.674

High

1029316

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

3

1

Small-scale

0.667

High

1328546

LATS2
Serine/threonine-protein kinase LATS2

3

1

Small-scale

0.662

High

1056978

MDC1
Mediator of DNA damage checkpoint protein 1

3

2

Small-scale

0.646

High

1288131

APC16
Anaphase-promoting complex subunit 16

3

0

High-throughput

0.638

High

887610

APC15
Anaphase-promoting complex subunit 15

3

0

Small-scale

0.638

High

1031271

SKP2
S-phase kinase-associated protein 2

3

0

Small-scale

0.638

High

1246272

CDC26
Anaphase-promoting complex subunit CDC26

3

0

High-throughput

0.634

High

1310882

APC13
Anaphase-promoting complex subunit 13

3

0

High-throughput

0.634

High

851354

NEK2
Serine/threonine-protein kinase Nek2

3

1

Small-scale

0.633

High

1328552

APC7
Anaphase-promoting complex subunit 7

3

11

Small-scale

0.624

High

1328557

FBX5
F-box only protein 5

2

0

Small-scale

0.612

High

861923

PLK1
Serine/threonine-protein kinase PLK1

2

2

High-throughput

0.611

High

1117492

ANO6
Anoctamin-6

2

0

High-throughput

0.602

High

1236493

SIR6
NAD-dependent protein deacylase sirtuin-6

2

1

Small-scale

0.584

High

370411

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

323118

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

917907

H4
Histone H4

2

0

High-throughput

0.559

High

1328550

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

1328560

TRI33
E3 ubiquitin-protein ligase TRIM33

2

0

Small-scale

0.559

High

1044144

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

0

High-throughput

0.547

High

970604

ID2
DNA-binding protein inhibitor ID-2

1

0

Small-scale

0.537

High

804339

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.536

High

1087396

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

245746

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

277355

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

426733

H10
Histone H1.0

1

0

High-throughput

0.513

High

735011

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

0

High-throughput

0.513

High

739831

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

813742

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

818456

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

828899

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

846526

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.513

High

929054

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.513

High

1039838

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1284802

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1303735

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1316200

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1318381

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1328544

PAK6
Serine/threonine-protein kinase PAK 6

1

0

High-throughput

0.513

High

1328562

CRYL1
Lambda-crystallin homolog

1

0

High-throughput

0.513

High

330210

PTTG1
Securin

1

0

Small-scale

0.480

High

349634

RASH
GTPase HRas

1

0

Small-scale

0.480

High

476355

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

902750

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

1086923

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.480

High

244922

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

275226

GRAP2
GRB2-related adapter protein 2

1

1

High-throughput

0.479

High

296344

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

Small-scale

0.479

High

325887

LATS1
Serine/threonine-protein kinase LATS1

1

1

Small-scale

0.479

High

707748

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

780082

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

808916

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

930993

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

Small-scale

0.479

High

1019125

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1173236

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

1198276

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

1

Small-scale

0.479

High

1269581

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1285349

PF21A
PHD finger protein 21A

1

1

High-throughput

0.479

High

1326733

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

1328545

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1328564

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

Small-scale

0.479

High

1282383

WBP2
WW domain-binding protein 2

1

0

Small-scale

0.460

High

210271

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

232497

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

295245

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

532610

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

538604

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

652213

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

897310

CSN2
COP9 signalosome complex subunit 2

1

0

Small-scale

0.458

High

903510

WDR5
WD repeat-containing protein 5

1

0

Small-scale

0.458

High

935225

H31
Histone H3.1

1

0

High-throughput

0.458

High

941423

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

964525

RELB
Transcription factor RelB

1

0

Small-scale

0.458

High

1034993

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.458

High

1042513

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1101282

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1219372

CUL9
Cullin-9

1

0

Small-scale

0.458

High

1242651

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1297196

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1328538

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

0

High-throughput

0.458

High

1328540

RPAP3
RNA polymerase II-associated protein 3

1

0

High-throughput

0.458

High

1328542

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1328547

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1328556

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

1328561

PHF8
Histone lysine demethylase PHF8

1

0

Small-scale

0.458

High

1328565

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

211247

BUB3
Mitotic checkpoint protein BUB3

1

1

High-throughput

0.445

High

1328559

APC10
Anaphase-promoting complex subunit 10

1

3

High-throughput

0.445

High

1067133

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.437

High

1328543

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.437

High

48722

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

1130573

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1186088

MICA3
[F-actin]-monooxygenase MICAL3

1

0

Small-scale

0.426

High

1223080

CCD13
Coiled-coil domain-containing protein 13

1

0

Small-scale

0.426

High

1326137

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.426

High

345200

KNG1
Kininogen-1

3

0

High-throughput

0.347

High

351626

PENK
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin

3

0

High-throughput

0.347

High

1253579

CMAP3
Ciliary microtubule-associated protein 3

3

0

High-throughput

0.347

High

1328541

MAGIX
PDZ domain-containing protein MAGIX

3

0

High-throughput

0.347

High

1161479

CP087
UPF0547 protein C16orf87

2

0

High-throughput

0.328

High

1244892

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.328

High

1327425

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.328

High

391898

H2A1B
Histone H2A type 1-B/E

2

0

High-throughput

0.318

High

551271

ITF2
Transcription factor 4

1

0

High-throughput

0.279

Low

1127366

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

1232964

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1233736

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.279

Low

1260773

DEP1B
DEP domain-containing protein 1B

1

0

High-throughput

0.279

Low

1297914

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

1318637

FOXQ1
Forkhead box protein Q1

1

0

High-throughput

0.279

Low

1328548

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

319328

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

327751

TTLL1
Polyglutamylase complex subunit TTLL1

1

0

High-throughput

0.249

Low

385495

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1116257

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

1159441

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1166868

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

1168677

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low

1171658

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1188845

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1238069

CE120
Centrosomal protein of 120 kDa

1

0

High-throughput

0.249

Low

1239322

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1263108

LIPH
Lipase member H

1

0

High-throughput

0.249

Low

1314724

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.249

Low

1328539

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1328549

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

1223614

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024