HitPredict

Interactor 1: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Interactor 2: SH22A (Q9NP31)
SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
Gene: SH2D2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1308 Hs			1 389
+	Hs
		548711 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		VAV_HUMAN (6-256): 4.43e-48: 176: 15.77
+	Hs
		454834 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		FGR_HUMAN (6-258): 5.75e-49: 175: 15.64
+	Hs
		522997 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SRC_HUMAN (21-280): 1.14e-48: 174: 17.73
+	Hs
		433770 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		LYN_HUMAN (9-313): 7.12e-48: 171: 14.82
+	Hs
		855797 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		VAV2_HUMAN (6-258): 3.29e-46: 171: 13.22
+	Hs
		802847 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		CRKL_HUMAN (95-347): 5.6e-49: 169: 21.76
+	Hs
		924589 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		GRB2_HUMAN (56-256): 4.42e-50: 169: 15.71
+	Hs
		433359 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		YES_HUMAN (7-280): 2.56e-46: 168: 16.56
+	Hs
		412202 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		FYN_HUMAN (38-280): 1.65e-45: 165: 15.67
+	Hs
		442833 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		HCK_HUMAN (6-212): 2.97e-45: 165: 15.93
+	Hs
		411729 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		802607 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		CRK_HUMAN (95-341): 6.51e-46: 161: 17.28
+	Hs
		275197 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		GRAP2_HUMAN (68-220): 2.23e-45: 160: 21.66
+	Hs
		1071000 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		HSH2D_HUMAN (76-257): 5.81e-43: 154: 31.32
+	Hs
		1046403 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		PTK6_HUMAN (84-194): 4.58e-32: 127: 28.93
+	Hs
		796580 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		KSYK_HUMAN (94-213): 1.09e-17: 86.9: 23.81
+	Hs
		796471 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		ZAP70_HUMAN (86-222): 1.53e-17: 86.1: 20.98
+	Rn
		1225226 Q8K3F9_RAT (6-1272): 0: 1096: 44.95		SRC_RAT (5-280): 5.38e-50: 177: 17.45
+	Hs
		411594 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		LCK_HUMAN (22-210): 4.42e-45: 164: 17.31
+	Hs
		275172 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		GRAP2_HUMAN (68-220): 2.23e-45: 160: 21.66