Protein: HAT1
Histone acetyltransferase type B catalytic subunit (EC 2.3.1.48) (Histone acetyltransferase 1)

Gene: HAT1
Organism: Homo sapiens
Interactions: 200
UniProt ID: O14929

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0004402 - histone acetyltransferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

168221

H4
Histone H4

8

5

Small-scale

0.972

High

168224

H31
Histone H3.1

14

8

Small-scale

0.759

High

168254

RBBP7
Histone-binding protein RBBP7

10

5

Small-scale

0.754

High

168231

RBBP4
Histone-binding protein RBBP4

5

5

High-throughput

0.721

High

168333

ASF1B
Histone chaperone ASF1B

5

2

Small-scale

0.716

High

168344

ASF1A
Histone chaperone ASF1A

4

2

High-throughput

0.704

High

168302

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

5

0

Small-scale

0.676

High

168229

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.646

High

168226

H33
Histone H3.3

3

8

Small-scale

0.640

High

168212

MEOX2
Homeobox protein MOX-2

2

1

High-throughput

0.633

High

168250

EZH2
Histone-lysine N-methyltransferase EZH2

2

1

Small-scale

0.624

High

168256

H31T
Histone H3.1t

2

8

Small-scale

0.602

High

168207

NASP
Nuclear autoantigenic sperm protein

2

0

High-throughput

0.602

High

168309

Z512B
Zinc finger protein 512B

2

0

High-throughput

0.585

High

168232

EP300
Histone acetyltransferase p300

2

1

High-throughput

0.584

High

168252

SNPC1
snRNA-activating protein complex subunit 1

2

0

High-throughput

0.580

High

168295

ZSCA4
Zinc finger and SCAN domain-containing protein 4

2

0

High-throughput

0.580

High

168314

TRIB3
Tribbles homolog 3

2

0

High-throughput

0.580

High

168325

STEEP
STING ER exit protein

2

0

High-throughput

0.580

High

168156

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

168186

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

168244

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

0

High-throughput

0.549

High

168205

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

0

High-throughput

0.547

High

168203

5HT2B
5-hydroxytryptamine receptor 2B

1

1

High-throughput

0.541

High

168300

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

0

Small-scale

0.537

High

166097

AIM2
Interferon-inducible protein AIM2

1

2

High-throughput

0.536

High

168171

SEMG1
Semenogelin-1

1

1

High-throughput

0.536

High

168175

KLK3
Prostate-specific antigen

1

1

High-throughput

0.536

High

168188

H2AX
Histone H2AX

1

2

Small-scale

0.536

High

168228

SEMG2
Semenogelin-2

1

1

High-throughput

0.536

High

168255

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.536

High

168271

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

168167

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

168176

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.513

High

168185

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

168191

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

168239

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

168243

CUL3
Cullin-3

1

0

High-throughput

0.513

High

168288

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

168303

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

168338

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.513

High

168193

1433T
14-3-3 protein theta

1

2

High-throughput

0.501

High

168257

H2A2C
Histone H2A type 2-C

1

2

Small-scale

0.501

High

168305

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.493

High

65621

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

1

1

High-throughput

0.489

High

168213

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.489

High

168219

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

0

Small-scale

0.480

High

168157

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

168162

MTA2
Metastasis-associated protein MTA2

1

2

High-throughput

0.479

High

168166

MBD3
Methyl-CpG-binding domain protein 3

1

1

High-throughput

0.479

High

168178

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

168187

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

168190

MCM3
DNA replication licensing factor MCM3

1

1

High-throughput

0.479

High

168196

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

2

High-throughput

0.479

High

168198

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

168204

ATRX
Transcriptional regulator ATRX

1

4

High-throughput

0.479

High

168208

CENPA
Histone H3-like centromeric protein A

1

8

High-throughput

0.479

High

168216

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

168222

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

168233

BPTF
Nucleosome-remodeling factor subunit BPTF

1

3

High-throughput

0.479

High

168234

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

2

High-throughput

0.479

High

168236

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

168238

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

168240

MTA1
Metastasis-associated protein MTA1

1

2

High-throughput

0.479

High

168245

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

168247

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

2

High-throughput

0.479

High

168248

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

4

High-throughput

0.479

High

168261

ARI4B
AT-rich interactive domain-containing protein 4B

1

1

High-throughput

0.479

High

168263

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

1

High-throughput

0.479

High

168272

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

168279

UBN2
Ubinuclein-2

1

1

High-throughput

0.479

High

168285

P66A
Transcriptional repressor p66-alpha

1

1

High-throughput

0.479

High

168298

IPO4
Importin-4

1

2

Small-scale

0.479

High

168301

P66B
Transcriptional repressor p66-beta

1

1

High-throughput

0.479

High

168317

MTA3
Metastasis-associated protein MTA3

1

2

High-throughput

0.479

High

168327

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

1

High-throughput

0.479

High

168330

UBN1
Ubinuclein-1

1

1

High-throughput

0.479

High

168332

HELLS
Lymphoid-specific helicase

1

3

Small-scale

0.479

High

168336

MBD2
Methyl-CpG-binding domain protein 2

1

1

High-throughput

0.479

High

168341

XPO7
Exportin-7

1

1

High-throughput

0.479

High

155258

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.458

High

168153

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

168154

PHF1
PHD finger protein 1

1

0

High-throughput

0.458

High

168158

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

168159

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.458

High

168161

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

168168

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

168169

ESR1
Estrogen receptor

1

0

High-throughput

0.458

High

168172

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

168179

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

168180

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

168181

MYBB
Myb-related protein B

1

0

High-throughput

0.458

High

168182

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

168183

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

168189

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.458

High

168192

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.458

High

168194

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

168197

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

168199

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

168201

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

168202

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

168206

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

168211

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

168215

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.458

High

168217

HIRA
Protein HIRA

1

0

High-throughput

0.458

High

168225

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

168230

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.458

High

168235

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

168237

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

168242

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

168246

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

168251

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

168260

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

168267

LIN9
Protein lin-9 homolog

1

0

High-throughput

0.458

High

168270

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

168275

CC174
Coiled-coil domain-containing protein 174

1

0

High-throughput

0.458

High

168280

ASXL2
Putative Polycomb group protein ASXL2

1

0

High-throughput

0.458

High

168281

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

168282

TLK2
Serine/threonine-protein kinase tousled-like 2

1

0

High-throughput

0.458

High

168289

CDAN1
Codanin-1

1

0

High-throughput

0.458

High

168290

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.458

High

168293

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

Small-scale

0.458

High

168299

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

168304

IRF7
Interferon regulatory factor 7

1

0

Small-scale

0.458

High

168307

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.458

High

168310

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

168313

PWP2A
PWWP domain-containing protein 2A

1

0

High-throughput

0.458

High

168315

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.458

High

168318

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.458

High

168320

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

168321

SP130
Histone deacetylase complex subunit SAP130

1

0

High-throughput

0.458

High

168323

BC11A
BCL11 transcription factor A

1

0

High-throughput

0.458

High

168326

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

168334

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

168335

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

168337

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.458

High

168339

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

168343

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

168345

CDIN1
CDAN1-interacting nuclease 1

1

0

High-throughput

0.458

High

168346

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

0

Small-scale

0.458

High

168347

CABIN
Calcineurin-binding protein cabin-1

1

0

High-throughput

0.458

High

168348

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.458

High

168209

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.438

High

168218

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.437

High

168278

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

168174

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

168241

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

168264

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

168286

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.426

High

168319

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

168342

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

50073

S22AN
Solute carrier family 22 member 23

1

2

High-throughput

0.407

High

168155

CTR4
Cationic amino acid transporter 4

1

1

High-throughput

0.407

High

168195

5HT2C
5-hydroxytryptamine receptor 2C

1

1

High-throughput

0.407

High

168214

CTR2
Cationic amino acid transporter 2

1

1

High-throughput

0.407

High

168227

SC6A3
Sodium-dependent dopamine transporter

1

1

High-throughput

0.407

High

168287

S22A9
Organic anion transporter 7

1

2

High-throughput

0.407

High

168291

SVOP
Synaptic vesicle 2-related protein

1

1

High-throughput

0.407

High

168296

MFSD9
Major facilitator superfamily domain-containing protein 9

1

3

High-throughput

0.407

High

168297

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.407

High

168311

MF14A
Hippocampus abundant transcript 1 protein

1

3

High-throughput

0.407

High

168329

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

1

High-throughput

0.407

High

168210

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

168170

VTNC
Vitronectin

3

0

High-throughput

0.345

High

168265

KANK4
KN motif and ankyrin repeat domain-containing protein 4

2

0

High-throughput

0.316

High

168268

MORN5
MORN repeat-containing protein 5

2

0

High-throughput

0.316

High

168312

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.316

High

168294

S15A4
Solute carrier family 15 member 4

2

0

Small-scale

0.313

High

168184

NCF1
Neutrophil cytosol factor 1

1

0

High-throughput

0.279

Low

168223

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.279

Low

168274

AAGAB
Alpha- and gamma-adaptin-binding protein p34

1

0

High-throughput

0.279

Low

168306

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.279

Low

168322

ATG10
Ubiquitin-like-conjugating enzyme ATG10

1

0

High-throughput

0.279

Low

168177

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

0

Small-scale

0.261

Low

168160

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

168163

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

168165

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

168173

SCG1
Secretogranin-1

1

0

High-throughput

0.249

Low

168200

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.249

Low

168220

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.249

Low

168259

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

168269

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

168276

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

168277

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

168292

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

168308

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

168316

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.249

Low

168324

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

168328

F204A
Protein FAM204A

1

0

High-throughput

0.249

Low

168340

HMGX4
HMG domain-containing protein 4

1

0

High-throughput

0.249

Low

168164

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low

168249

S39AE
Metal cation symporter ZIP14

1

0

High-throughput

0.232

Low

168253

B2LA1
Bcl-2-related protein A1

1

0

Small-scale

0.232

Low

168258

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

0

High-throughput

0.232

Low

168262

CTL4
Choline transporter-like protein 4

1

0

High-throughput

0.232

Low

168266

FAXC
Failed axon connections homolog

1

0

High-throughput

0.232

Low

168273

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

168283

SO6A1
Solute carrier organic anion transporter family member 6A1

1

0

High-throughput

0.232

Low

168284

UN93A
Protein unc-93 homolog A

1

0

High-throughput

0.232

Low

168331

S17A5
Sialin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025