HitPredict

Interactor 1: KS6A1 (Q15418)
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
Gene: RPS6KA1

Interactor 2: SNX27 (Q96L92)
Sorting nexin-27
Gene: SNX27

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	0.60	0.408

Property	Details
Experiments	30726710
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 735 Hs			1 541
+	Hs
		850702 KS6A3_HUMAN (1-735): 0: 791: 79.14		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Hs
		682200 AKT2_HUMAN (326-719): 8.47e-124: 379: 22.11		SNX27_HUMAN (1-541): 0: 625: 100.00
+	Hs
		1073494 KS6A1_HUMAN (1-735): 0: 836: 100.00		NEB1_HUMAN (40-375): 2.86e-39: 155: 14.43
+	Hs
		1073438 KS6A1_HUMAN (1-735): 0: 836: 100.00		PZRN4_HUMAN (30-303): 9.57e-36: 144: 16.61
+	Hs
		1073442 KS6A1_HUMAN (1-735): 0: 836: 100.00		GRASP_HUMAN (7-172): 1.34e-36: 142: 24.86
+	Hs
		1073495 KS6A1_HUMAN (1-735): 0: 836: 100.00		PZRN3_HUMAN (21-281): 3.18e-33: 136: 17.10
+	Hs
		1033837 KS6A1_HUMAN (1-735): 0: 836: 100.00		SNTA1_HUMAN (1-188): 2.48e-29: 123: 20.10
+	Hs
		59889 KS6A1_HUMAN (1-735): 0: 836: 100.00		GRD2I_HUMAN (32-180): 7.32e-28: 120: 24.38
+	Hs
		1073423 KS6A1_HUMAN (1-735): 0: 836: 100.00		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		1073479 KS6A1_HUMAN (1-735): 0: 836: 100.00		SHAN3_HUMAN (44-148): 1.57e-21: 101: 37.14
+	Hs
		1073444 KS6A1_HUMAN (1-735): 0: 836: 100.00		MAGI2_HUMAN (45-372): 3.17e-16: 84.6: 14.79
+	Hs
		1073433 KS6A1_HUMAN (1-735): 0: 836: 100.00		NHRF3_HUMAN (38-313): 4.98e-16: 82.7: 13.70
+	Hs
		1073434 KS6A1_HUMAN (1-735): 0: 836: 100.00		MAGI3_HUMAN (19-429): 6.34e-14: 77.3: 15.39
+	Hs
		1073470 KS6A1_HUMAN (1-735): 0: 836: 100.00		MAGI1_HUMAN (2-334): 3.18e-13: 74.9: 17.51
+	Hs
		850657 KS6A3_HUMAN (1-735): 0: 791: 79.14		NHRF2_HUMAN (9-207): 1.8e-24: 106: 21.78
+	Hs
		153900 KS6A3_HUMAN (1-735): 0: 791: 79.14		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Rn
		193535 KS6B1_RAT (393-727): 4.33e-113: 353: 24.65		NEB1_RAT (40-375): 5.28e-41: 160: 14.43
+	Hs
		682072 AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92		SHAN2_HUMAN (43-147): 7.14e-29: 124: 38.10
+	Hs
		153882 AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92		NHRF1_HUMAN (12-209): 7.91e-23: 101: 22.89
+	Hs
		681891 AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92		NHRF3_HUMAN (38-313): 4.98e-16: 82.7: 13.70