Protein: PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GAR synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIR synthetase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase)]

Gene: PUR2, ADE57
Organism: Saccharomyces cerevisiae S288C
Interactions: 92
UniProt ID: P07244

Gene Ontology (top 5):
GO:0004637 - phosphoribosylamine-glycine ligase activity
GO:0004641 - phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

392006

HSP82
ATP-dependent molecular chaperone HSP82

3

1

Small-scale

0.633

High

434692

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.585

High

452542

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

2

0

High-throughput

0.585

High

452470

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.571

High

452479

SIS1
Protein SIS1

2

1

High-throughput

0.571

High

452518

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

452508

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

452510

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.536

High

452511

RFC2
Replication factor C subunit 2

1

1

High-throughput

0.536

High

437861

KAPC
cAMP-dependent protein kinase type 3

1

0

High-throughput

0.513

High

452484

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.513

High

452503

LSM2
LSM complex subunit LSM2

1

0

High-throughput

0.513

High

452504

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.513

High

452525

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

452535

PIN3
[PSI+] inducibility protein 3

1

1

High-throughput

0.508

High

452485

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.493

High

452473

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

452500

AKL1
Serine/threonine-protein kinase AKL1

1

0

High-throughput

0.480

High

452516

BNI1
Protein BNI1

1

0

High-throughput

0.480

High

452476

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.479

High

452488

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.479

High

452493

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.479

High

452515

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.479

High

452526

AP1M1
AP-1 complex subunit mu-1-I

1

0

High-throughput

0.479

High

452463

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.479

High

452466

ARF1
ADP-ribosylation factor 1

1

1

High-throughput

0.479

High

452474

UPP
Uracil phosphoribosyltransferase

1

1

High-throughput

0.479

High

452486

URK1
Uridine kinase

1

1

High-throughput

0.479

High

452492

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

452507

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

452530

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

452540

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.479

High

452541

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

368545

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

383415

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

452460

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

452461

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

452462

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

452468

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

452477

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

452478

KCC2
Calcium/calmodulin-dependent protein kinase II

1

0

High-throughput

0.458

High

452481

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

452483

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

452490

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

452491

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

452494

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.458

High

452497

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

452505

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

452512

TM108
Protein TMA108

1

0

High-throughput

0.458

High

452519

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

452522

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

452524

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

452528

ESP1
Separin

1

0

High-throughput

0.458

High

452536

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

452537

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

452539

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

452464

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

452465

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

452467

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

452489

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

452532

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

3

High-throughput

0.445

High

386517

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

394109

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

452459

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

452471

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

452472

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

452482

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

452506

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.426

High

452509

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.426

High

452517

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

452529

WDR59
Maintenance of telomere capping protein 5

1

1

High-throughput

0.407

High

452475

REB1
DNA-binding protein REB1

2

0

High-throughput

0.324

High

452480

CDC10
Cell division control protein 10

1

0

High-throughput

0.261

Low

452501

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

0

High-throughput

0.261

Low

452469

TBP
TATA-box-binding protein

1

0

High-throughput

0.249

Low

452487

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

452495

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

452496

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

452499

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

452502

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

452513

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

452514

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

452521

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

452531

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

452533

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

452534

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

452538

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

452498

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low

452520

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low

452523

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.232

Low

452527

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.232

Low

452543

H2AZ
Histone H2A.Z

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025