HitPredict

Interactor 1: MED22 (Q15528)
Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)
Gene: MED22

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	33961781, 26496610, 24981860, 20133760
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex GO:0060261 - positive regulation of transcription initiation by RNA polymerase II
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 200 Hs			1 2177
+	Hs
		92485 E9PGW7_HUMAN (1-111): 8.84e-50: 158: 100.00		MED12_HUMAN (1-2177): 0: 2488: 100.00
+	Hs
		1074711 MED22_HUMAN (1-200): 2.43e-99: 287: 100.00		MD12L_HUMAN (1-2175): 0: 2159: 56.63