HitPredict

Interactor 1: G5EG62 (G5EG62)
UNC-45
Gene: unc-45

Interactor 2: UBE4 (Q09349)
Ubiquitin conjugation factor E4 ufd-2 (EC 2.3.2.27) (E4 ubiquitin-protein ligase ufd-2) (RING-type E3 ubiquitin transferase E4) (Ubiquitin fusion degradation protein 2)
Gene: ufd-2

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.665

Property	Details
Experiments	17369820, 29396393, 15294159
Identification Methods	two hybrid, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 961 Ce			1 984
+	Ce
		105585 G5EG62_CAEEL (1-961): 0: 898: 100.00		G5ECY6_CAEEL (742-983): 8.59e-47: 170: 19.34
+	Hs
		1219699 UN45B_HUMAN (7-943): 0: 822: 30.55		CHIP_HUMAN (731-979): 3.07e-53: 190: 15.59
+	Mm
		93689 DNJC7_MOUSE (3-309): 4.27e-18: 90.7: 13.03		UBE4A_MOUSE (70-984): 0: 705: 21.72
+	Hs
		1305147 DNJC7_HUMAN (3-309): 1.76e-18: 91.8: 13.36		CHIP_HUMAN (731-979): 3.07e-53: 190: 15.59