Protein: ZC3H1
Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2)

Gene: ZC3H1, ZFC3H1
Organism: Homo sapiens
Interactions: 192
UniProt ID: O60293

Gene Ontology (top 5):
GO:0000178 - exosome (RNase complex)
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0006396 - RNA processing
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

244652

MTREX
Exosome RNA helicase MTR4

1

4

High-throughput

0.691

High

244701

EXOS7
Exosome complex component RRP42

3

5

High-throughput

0.667

High

244630

A4
Amyloid-beta precursor protein

4

0

High-throughput

0.666

High

244774

EXOS5
Exosome complex component RRP46

3

6

High-throughput

0.662

High

244762

MPH6
M-phase phosphoprotein 6

3

1

High-throughput

0.650

High

244801

DCAF1
DDB1- and CUL4-associated factor 1

3

0

High-throughput

0.646

High

224187

BUB3
Mitotic checkpoint protein BUB3

4

1

High-throughput

0.638

High

244725

ZCH18
Zinc finger CCCH domain-containing protein 18

3

0

High-throughput

0.638

High

244693

C1D
Nuclear nucleic acid-binding protein C1D

3

0

High-throughput

0.634

High

244624

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

1

High-throughput

0.628

High

244657

MK09
Mitogen-activated protein kinase 9

2

1

High-throughput

0.628

High

244669

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

1

High-throughput

0.628

High

244728

RBM45
RNA-binding protein 45

2

1

High-throughput

0.628

High

244763

PAPOG
Poly(A) polymerase gamma

2

1

High-throughput

0.628

High

244771

MOV10
Helicase MOV-10

2

1

High-throughput

0.628

High

244697

SLBP
Histone RNA hairpin-binding protein

2

0

High-throughput

0.602

High

244724

TBCD1
TBC1 domain family member 1

2

0

High-throughput

0.602

High

244733

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.602

High

244737

CARME
Carnosine N-methyltransferase

2

0

High-throughput

0.602

High

244749

XPF
DNA repair endonuclease XPF

2

0

High-throughput

0.602

High

244758

ANM6
Protein arginine N-methyltransferase 6

2

0

High-throughput

0.602

High

244776

SMYD2
N-lysine methyltransferase SMYD2

2

0

High-throughput

0.602

High

244791

SUFU
Suppressor of fused homolog

2

0

High-throughput

0.602

High

244772

EXOS4
Exosome complex component RRP41

2

6

High-throughput

0.601

High

244703

TBCE
Tubulin-specific chaperone E

2

1

High-throughput

0.574

High

244712

ANGE2
Protein angel homolog 2

2

1

High-throughput

0.574

High

244715

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

2

1

High-throughput

0.574

High

244628

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

244699

DHX8
ATP-dependent RNA helicase DHX8

2

2

High-throughput

0.571

High

244666

RL23A
Large ribosomal subunit protein uL23

2

0

High-throughput

0.559

High

244731

ANKH1
Ankyrin repeat and KH domain-containing protein 1

2

2

High-throughput

0.558

High

244670

CSK21
Casein kinase II subunit alpha

1

2

High-throughput

0.550

High

191490

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

244633

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.536

High

244641

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.536

High

244655

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.536

High

244662

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.536

High

244684

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

244692

EXOS2
Exosome complex component RRP4

1

1

High-throughput

0.536

High

244705

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.536

High

244714

LAR1B
La-related protein 1B

1

2

High-throughput

0.536

High

244720

DHX30
ATP-dependent RNA helicase DHX30

1

1

High-throughput

0.536

High

244734

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

1

High-throughput

0.536

High

244750

RENT1
Regulator of nonsense transcripts 1

1

1

High-throughput

0.536

High

244767

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

3

High-throughput

0.536

High

244780

RBM27
RNA-binding protein 27

1

1

High-throughput

0.536

High

244786

RALY
RNA-binding protein Raly

1

1

High-throughput

0.536

High

244796

EXOS1
Exosome complex component CSL4

1

3

High-throughput

0.536

High

244704

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

244636

H14
Histone H1.4

1

2

High-throughput

0.515

High

244639

H15
Histone H1.5

1

2

High-throughput

0.515

High

244640

H12
Histone H1.2

1

2

High-throughput

0.515

High

244622

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.513

High

244634

SRGN
Serglycin

1

0

High-throughput

0.513

High

244648

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

244651

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

244656

KSYK
Tyrosine-protein kinase SYK

1

0

High-throughput

0.513

High

244659

MAPK2
MAP kinase-activated protein kinase 2

1

0

High-throughput

0.513

High

244660

YLPM1
YLP motif-containing protein 1

1

0

High-throughput

0.513

High

244688

PABP4
Polyadenylate-binding protein 4

1

0

High-throughput

0.513

High

244689

DGKZ
Diacylglycerol kinase zeta

1

0

High-throughput

0.513

High

244690

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.513

High

244691

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.513

High

244698

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.513

High

244709

ZN326
DBIRD complex subunit ZNF326

1

0

High-throughput

0.513

High

244711

PCID2
PCI domain-containing protein 2

1

0

High-throughput

0.513

High

244721

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

244723

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

244756

THOC1
THO complex subunit 1

1

0

High-throughput

0.513

High

244759

LENG8
Leukocyte receptor cluster member 8

1

0

High-throughput

0.513

High

244784

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

244798

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.513

High

244793

NINL
Ninein-like protein

1

1

High-throughput

0.494

High

244642

BDNF
Neurotrophic factor BDNF precursor form

1

0

High-throughput

0.493

High

244687

SRSF6
Serine/arginine-rich splicing factor 6

1

1

High-throughput

0.489

High

244717

LARP1
La-related protein 1

1

2

High-throughput

0.489

High

244788

ANR50
Ankyrin repeat domain-containing protein 50

1

2

High-throughput

0.489

High

244802

TACC3
Transforming acidic coiled-coil-containing protein 3

1

1

High-throughput

0.489

High

244637

TRI27
Zinc finger protein RFP

1

1

High-throughput

0.481

High

244665

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

1

High-throughput

0.481

High

244686

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

3

High-throughput

0.481

High

244710

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

3

High-throughput

0.481

High

244713

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

1

High-throughput

0.481

High

244746

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

244672

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.480

High

244635

MYB
Transcriptional activator Myb

1

1

High-throughput

0.479

High

244649

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

244653

HD
Huntingtin

1

1

High-throughput

0.479

High

244661

NCBP2
Nuclear cap-binding protein subunit 2

1

2

High-throughput

0.479

High

244667

H4
Histone H4

1

1

High-throughput

0.479

High

244678

EXOSX
Exosome complex component 10

1

1

High-throughput

0.479

High

244727

MIB1
E3 ubiquitin-protein ligase MIB1

1

3

Small-scale

0.479

High

244748

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

244751

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

128649

MEN1
Menin

1

0

High-throughput

0.458

High

244629

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.458

High

244638

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

244644

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.458

High

244645

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

244658

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

244671

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

244679

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

244685

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

244716

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

244722

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

244735

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

244738

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

244745

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

244773

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

244781

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

244792

SNX6
Sorting nexin-6

1

0

High-throughput

0.458

High

244799

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

244761

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.457

High

244625

HSF2B
Heat shock factor 2-binding protein

1

1

High-throughput

0.439

High

244683

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.439

High

244707

CCD57
Coiled-coil domain-containing protein 57

1

2

High-throughput

0.439

High

244729

ZDH17
Palmitoyltransferase ZDHHC17

1

5

High-throughput

0.439

High

244740

DOCK8
Dedicator of cytokinesis protein 8

1

1

High-throughput

0.439

High

244744

CEP70
Centrosomal protein of 70 kDa

1

1

High-throughput

0.439

High

244760

SPAG5
Sperm-associated antigen 5

1

2

High-throughput

0.439

High

244790

CAPS1
Calcium-dependent secretion activator 1

1

1

High-throughput

0.439

High

244795

COG6
Conserved oligomeric Golgi complex subunit 6

1

1

High-throughput

0.439

High

244682

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

244785

TNIK
TRAF2 and NCK-interacting protein kinase

1

0

High-throughput

0.438

High

140676

NOP56
Nucleolar protein 56

1

2

High-throughput

0.437

High

244626

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.437

High

244696

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

244719

CE128
Centrosomal protein of 128 kDa

1

1

High-throughput

0.437

High

244732

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.437

High

244741

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.437

High

244742

O10G4
Olfactory receptor 10G4

1

1

High-throughput

0.437

High

244743

O10G9
Olfactory receptor 10G9

1

1

High-throughput

0.437

High

244766

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.437

High

244643

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.426

High

244646

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

96869

E9PDP5
Ankyrin repeat and KH domain containing 1

1

2

High-throughput

0.407

High

116286

H3BNT4
M-phase phosphoprotein 6

1

1

High-throughput

0.407

High

244675

RT05
Small ribosomal subunit protein uS5m

2

0

High-throughput

0.328

High

244676

RT11
Small ribosomal subunit protein uS11m

2

0

High-throughput

0.328

High

244681

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

2

0

High-throughput

0.328

High

244708

VP26B
Vacuolar protein sorting-associated protein 26B

2

0

High-throughput

0.328

High

244736

FBXW8
F-box/WD repeat-containing protein 8

2

0

High-throughput

0.328

High

244739

PPHLN
Periphilin-1

2

0

High-throughput

0.328

High

244753

RT24
Small ribosomal subunit protein uS3m

2

0

High-throughput

0.328

High

244754

PTCD3
Small ribosomal subunit protein mS39

2

0

High-throughput

0.328

High

244765

SRRT
Serrate RNA effector molecule homolog

2

0

High-throughput

0.328

High

244782

GPN3
GPN-loop GTPase 3

2

0

High-throughput

0.328

High

244794

RT07
Small ribosomal subunit protein uS7m

2

0

High-throughput

0.328

High

244650

GRIK1
Glutamate receptor ionotropic, kainate 1

1

0

High-throughput

0.282

High

244702

ITSN1
Intersectin-1

1

0

High-throughput

0.282

High

65991

U119B
Protein unc-119 homolog B

1

0

High-throughput

0.279

Low

244623

RT14
Small ribosomal subunit protein uS14m

1

0

High-throughput

0.279

Low

244631

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.279

Low

244632

ERCC1
DNA excision repair protein ERCC-1

1

0

High-throughput

0.279

Low

244663

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.279

Low

244664

ACTZ
Alpha-centractin

1

0

High-throughput

0.279

Low

244673

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.279

Low

244674

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.279

Low

244677

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.279

Low

244695

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.279

Low

244700

CUL7
Cullin-7

1

0

High-throughput

0.279

Low

244706

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

244730

FABD
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial

1

0

High-throughput

0.279

Low

244747

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.279

Low

244752

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.279

Low

244770

NOL6
Nucleolar protein 6

1

0

High-throughput

0.279

Low

244777

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

244779

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

244787

MYH13
Myosin-13

1

0

High-throughput

0.279

Low

244797

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.279

Low

244800

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.269

Low

175283

PLXB2
Plexin-B2

1

0

High-throughput

0.249

Low

190751

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.249

Low

244627

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.249

Low

244647

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

244654

PF2R
Prostaglandin F2-alpha receptor

1

0

High-throughput

0.249

Low

244694

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.249

Low

244757

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

244764

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low

244768

GAN
Gigaxonin

1

0

High-throughput

0.249

Low

244769

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

244775

ANLN
Anillin

1

0

High-throughput

0.249

Low

244778

DJC17
DnaJ homolog subfamily C member 17

1

0

High-throughput

0.249

Low

244783

S12A6
Solute carrier family 12 member 6

1

0

Small-scale

0.249

Low

244789

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

62424

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

132899

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.232

Low

244668

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.232

Low

244680

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.232

Low

244718

S39A5
Zinc transporter ZIP5

1

0

High-throughput

0.232

Low

244726

S13A5
Na(+)/citrate cotransporter

1

0

High-throughput

0.232

Low

244755

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025