HitPredict

Interactor 1: E2F4 (Q16254)
Transcription factor E2F4 (E2F-4)
Gene: E2F4

Interactor 2: TFDP3 (Q5H9I0)
Transcription factor Dp family member 3 (Cancer/testis antigen 30) (CT30) (Hepatocellular carcinoma-associated antigen 661)
Gene: TFDP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DP~E2F_CC-MB, E2F_TDP~E2F_TDP
Common GO terms	GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 413 Hs			1 405
+	Hs
		1050507 E2F4_HUMAN (1-413): 0: 528: 100.00		TFDP1_HUMAN (1-383): 0: 678: 76.35
+	Mm
		996145 E2F4_MOUSE (1-413): 4.62e-177: 501: 92.03		TFDP1_MOUSE (1-383): 0: 658: 74.04
+	Hs
		1050555 E2F4_HUMAN (1-413): 0: 528: 100.00		TFDP2_HUMAN (2-362): 0: 529: 50.90
+	Mm
		1145033 E2F4_MOUSE (1-413): 4.62e-177: 501: 92.03		TFDP2_MOUSE (2-383): 5.3e-178: 505: 45.33
+	Hs
		1050501 E2F2_HUMAN (4-252): 2.04e-83: 263: 43.83		TFDP1_HUMAN (1-383): 0: 678: 76.35
+	Hs
		963615 E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29		TFDP1_HUMAN (1-383): 0: 678: 76.35
+	Hs
		135247 E2F3_HUMAN (5-289): 3.49e-79: 253: 36.93		TFDP1_HUMAN (1-383): 0: 678: 76.35
+	Hs
		265645 E2F6_HUMAN (17-244): 1.21e-72: 230: 34.35		TFDP1_HUMAN (1-383): 0: 678: 76.35
+	Hs
		135260 E2F3_HUMAN (5-289): 3.49e-79: 253: 36.93		TFDP3_HUMAN (1-405): 0: 617: 100.00
+	Hs
		1050552 E2F2_HUMAN (4-252): 2.04e-83: 263: 43.83		TFDP2_HUMAN (2-362): 0: 529: 50.90
+	Mm
		405 E2F2_MOUSE (4-244): 2.59e-82: 260: 43.09		A0A087WPU8_MOUSE (2-383): 0: 530: 47.66
+	Hs
		963616 E2F1_HUMAN (10-278): 8.99e-81: 257: 35.29		TFDP2_HUMAN (2-362): 0: 529: 50.90
+	Hs
		135248 E2F3_HUMAN (5-289): 3.49e-79: 253: 36.93		TFDP2_HUMAN (2-362): 0: 529: 50.90
+	Mm
		99867 E2F2_MOUSE (4-244): 2.59e-82: 260: 43.09		F6QG91_MOUSE (57-383): 5e-161: 459: 49.19
+	At
		1324892 E2FA_ARATH (3-298): 3.72e-103: 316: 35.33		DPB_ARATH (98-300): 1.1e-97: 298: 41.95
+	At
		1324893 E2FA_ARATH (3-298): 3.72e-103: 316: 35.33		DPA_ARATH (102-298): 3.21e-84: 260: 33.17
+	At
		1324900 E2FB_ARATH (4-279): 6.71e-80: 255: 33.12		DPB_ARATH (98-300): 1.1e-97: 298: 41.95
+	At
		1324899 E2FC_ARATH (1-226): 4.63e-77: 245: 41.30		DPB_ARATH (98-300): 1.1e-97: 298: 41.95
+	At
		1324909 E2FB_ARATH (4-279): 6.71e-80: 255: 33.12		DPA_ARATH (102-298): 3.21e-84: 260: 33.17
+	At
		1324908 E2FC_ARATH (1-226): 4.63e-77: 245: 41.30		DPA_ARATH (102-298): 3.21e-84: 260: 33.17