HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25147182, 25883150
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006511 - ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 4374
+	Hs
		1073040 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		1082383 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WWP1_HUMAN (3507-4372): 0: 613: 22.55
+	Hs
		125477 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		125413 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		808107 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46