Protein: NSMA3
Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III)

Gene: NSMA3, SMPD4
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q9NXE4

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004767 - sphingomyelin phosphodiesterase activity
GO:0005635 - nuclear envelope
GO:0005640 - nuclear outer membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360479

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

2

High-throughput

0.640

High

890465

SC61B
Protein transport protein Sec61 subunit beta

2

0

High-throughput

0.559

High

834678

NU153
Nuclear pore complex protein Nup153

1

1

High-throughput

0.536

High

384001

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

High-throughput

0.526

High

884798

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.513

High

1053829

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1060945

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

1083614

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

1253093

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

1283304

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1299263

OPALI
Opalin

1

0

High-throughput

0.513

High

1328614

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1334980

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.493

High

126483

FOXE1
Forkhead box protein E1

1

6

High-throughput

0.489

High

270838

FOXH1
Forkhead box protein H1

1

7

High-throughput

0.489

High

878012

FOXA3
Hepatocyte nuclear factor 3-gamma

1

7

High-throughput

0.489

High

885186

FOXL2
Forkhead box protein L2

1

7

High-throughput

0.489

High

1021261

FOXI1
Forkhead box protein I1

1

7

High-throughput

0.489

High

1021363

FOXL1
Forkhead box protein L1

1

7

High-throughput

0.489

High

1153751

STYK1
Tyrosine-protein kinase STYK1

1

1

High-throughput

0.489

High

1169833

FOXI2
Forkhead box protein I2

1

6

High-throughput

0.489

High

1306873

FOXB1
Forkhead box protein B1

1

7

High-throughput

0.489

High

48536

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

120672

RHOD
Rho-related GTP-binding protein RhoD

1

5

High-throughput

0.479

High

169210

MUSK
Muscle, skeletal receptor tyrosine-protein kinase

1

2

High-throughput

0.479

High

350610

RASK
GTPase KRas

1

2

High-throughput

0.479

High

436537

RHOC
Rho-related GTP-binding protein RhoC

1

4

High-throughput

0.479

High

507270

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.479

High

545656

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.479

High

567296

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

591698

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.479

High

592535

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.479

High

595445

LMNB1
Lamin-B1

1

2

High-throughput

0.479

High

844769

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.479

High

845772

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

892626

RAC3
Ras-related C3 botulinum toxin substrate 3

1

4

High-throughput

0.479

High

894505

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.479

High

900973

RHOA
Transforming protein RhoA

1

5

High-throughput

0.479

High

1017822

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1077141

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.479

High

1167901

DJC14
DnaJ homolog subfamily C member 14

1

1

High-throughput

0.479

High

1263918

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.479

High

1282662

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

High-throughput

0.479

High

1296094

DNJC1
DnaJ homolog subfamily C member 1

1

3

High-throughput

0.479

High

1301238

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

1

High-throughput

0.479

High

1311426

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1328869

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.479

High

1347928

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1347929

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.479

High

118479

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

132613

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.458

High

164015

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

213027

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

228888

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

274013

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

305655

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

315221

CNEP1
CTD nuclear envelope phosphatase 1

1

0

High-throughput

0.458

High

390574

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

391213

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

456950

FURIN
Furin

1

0

High-throughput

0.458

High

514730

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.458

High

573942

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

652424

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

654840

CALX
Calnexin

1

0

High-throughput

0.458

High

786161

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

795308

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

825573

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

839184

EMD
Emerin

1

0

High-throughput

0.458

High

847690

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

881689

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

913146

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

914403

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

961853

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

990712

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1040282

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1053223

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1148243

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

1168709

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1188414

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1188946

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1218527

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1220999

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1240334

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1243418

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1244729

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1284115

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1300797

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1303600

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1313079

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1319272

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1329302

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1333597

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1346184

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1347709

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1347754

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

1347924

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1347927

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1347934

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.458

High

1347935

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

178017

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

178815

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

268307

EED
Polycomb protein EED

1

1

High-throughput

0.437

High

385613

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

592036

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.437

High

729370

VGFR3
Vascular endothelial growth factor receptor 3

1

1

High-throughput

0.437

High

852648

RND2
Rho-related GTP-binding protein RhoN

1

6

High-throughput

0.437

High

877641

FOXG1
Forkhead box protein G1

1

7

High-throughput

0.437

High

1070419

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.437

High

1076788

RHOH
Rho-related GTP-binding protein RhoH

1

5

High-throughput

0.437

High

1198201

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

1220689

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.437

High

1230400

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1345075

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

1347930

ANC2
Anaphase-promoting complex subunit 2

1

1

High-throughput

0.437

High

1347931

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

1347932

ALK
ALK tyrosine kinase receptor

1

2

High-throughput

0.437

High

1347933

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.437

High

354583

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

1130658

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1347528

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

172259

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

796038

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.279

Low

1041479

CUL2
Cullin-2

1

0

High-throughput

0.279

Low

1075261

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.279

Low

1233056

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1266048

AQP3
Aquaporin-3

1

0

High-throughput

0.279

Low

1347936

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1243165

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.269

Low

1342620

EXOS4
Exosome complex component RRP41

1

0

High-throughput

0.265

Low

283049

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.249

Low

504858

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.249

Low

535585

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.249

Low

545051

AMPN
Aminopeptidase N

1

0

High-throughput

0.249

Low

665536

EPHA8
Ephrin type-A receptor 8

1

0

High-throughput

0.249

Low

670248

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.249

Low

721609

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

780206

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

824454

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

940580

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.249

Low

941503

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1087622

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1135149

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.249

Low

1145954

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.249

Low

1146894

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.249

Low

1156733

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

1171990

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1199618

LBN
Limbin

1

0

High-throughput

0.249

Low

1203877

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1204349

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1269764

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1283961

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1303187

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1305120

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.249

Low

1331452

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1344327

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.249

Low

1344448

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1347925

WSB2
WD repeat and SOCS box-containing protein 2

1

0

High-throughput

0.249

Low

1347926

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

398112

ISG15
Ubiquitin-like protein ISG15

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024