HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: SKI8 (Q9GZS3)
Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]
Gene: SKIC8

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31155351
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016055 - Wnt signaling pathway
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 305
+	Mm
		1112307 DDB1_MOUSE (1-1140): 0: 1422: 99.65		SKI8_MOUSE (1-305): 5.48e-100: 297: 97.38
+	Hs
		1082327 DDB1_HUMAN (1-1140): 0: 1424: 100.00		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (179-304): 1.89e-37: 137: 30.95
+	Hs
		1016284 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL3_HUMAN (151-265): 1.22e-09: 61.2: 28.93
+	Hs
		1073144 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		SKI8_HUMAN (1-305): 2.86e-101: 300: 100.00
+	Hs
		1073168 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		NLE1_HUMAN (7-304): 9.15e-91: 279: 21.61
+	At
		1340746 DDB1A_ARATH (2-1140): 0: 1255: 52.09		VIP3_ARATH (4-136): 8.34e-25: 103: 23.74
+	At
		221835 DDB1B_ARATH (3-1140): 0: 1248: 50.92		VIP3_ARATH (4-136): 8.34e-25: 103: 23.74
+	At
		95049 DDB1A_ARATH (2-1140): 0: 1255: 52.09		KTN82_ARATH (118-302): 1.41e-14: 76.3: 24.32
+	At
		95047 DDB1B_ARATH (3-1140): 0: 1248: 50.92		KTN82_ARATH (118-302): 1.41e-14: 76.3: 24.32
+	Hs
		1073094 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		FBXW7_HUMAN (91-303): 1.6e-63: 214: 24.30
+	Hs
		267761 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		TAF5L_HUMAN (24-208): 1.33e-09: 60.8: 25.76
+	Hs
		1014208 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		NLE1_HUMAN (7-304): 9.15e-91: 279: 21.61
+	Hs
		197009 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		PRP4_HUMAN (218-304): 3.86e-14: 74.2: 13.68