HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: WDR76 (Q9H967)
WD repeat-containing protein 76
Gene: WDR76

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27248496, 31353912
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0006974 - DNA damage response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1140 Hs			1 626
+	Mm
		1112296 DDB1_MOUSE (1-1140): 0: 1422: 99.65		DDB2_MOUSE (201-610): 1.91e-92: 293: 20.46
+	Hs
		1082292 DDB1_HUMAN (1-1140): 0: 1424: 100.00		COP1_HUMAN (154-619): 7.6e-71: 245: 14.96
+	Hs
		1082302 DDB1_HUMAN (1-1140): 0: 1424: 100.00		DDB2_HUMAN (201-625): 1.38e-70: 236: 21.51
+	Hs
		1028001 DDB1_HUMAN (1-1140): 0: 1424: 100.00		ERCC8_HUMAN (305-532): 1.35e-57: 200: 19.92
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (395-624): 2.14e-51: 182: 11.74
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (435-622): 2.2e-42: 157: 12.23
+	Hs
		245605 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1X_HUMAN (248-479): 3.7e-39: 153: 13.67
+	Hs
		1082327 DDB1_HUMAN (1-1140): 0: 1424: 100.00		SNR40_HUMAN (440-625): 1.07e-33: 134: 11.83
+	At
		1155299 DDB1A_ARATH (2-1140): 0: 1255: 52.09		DDB2_ARATH (244-613): 4.89e-94: 302: 24.31
+	Hs
		1073152 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		WDR76_HUMAN (1-626): 1.19e-151: 453: 100.00
+	Hs
		997738 DDB1_HUMAN (1-1140): 0: 1424: 100.00		RBBP4_HUMAN (233-477): 2.84e-19: 92.6: 14.55
+	Hs
		1073094 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		FBXW7_HUMAN (180-616): 3.15e-66: 231: 11.79
+	Hs
		1073168 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		NLE1_HUMAN (181-575): 1.3e-63: 219: 12.70
+	At
		1340747 DDB1A_ARATH (2-1140): 0: 1255: 52.09		SPA2_ARATH (452-626): 1.02e-09: 63.6: 11.24
+	At
		221836 DDB1B_ARATH (3-1140): 0: 1248: 50.92		SPA2_ARATH (452-626): 1.02e-09: 63.6: 11.24
+	Hs
		1028000 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		ERCC8_HUMAN (305-532): 1.35e-57: 200: 19.92
+	Ce
		219829 O44985_CAEEL (3-1126): 0: 1035: 19.76		LIN53_CAEEL (251-477): 2.75e-20: 95.7: 15.73
+	Hs
		1014208 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		NLE1_HUMAN (181-575): 1.3e-63: 219: 12.70
+	Hs
		197009 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		PRP4_HUMAN (401-624): 5.45e-40: 155: 15.09
+	Ce
		954081 CPSF1_CAEEL (3-565): 2.56e-112: 384: 22.27		LIN53_CAEEL (251-477): 2.75e-20: 95.7: 15.73