HitPredict

Interactor 1: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Interactor 2: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28213521
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 630
+	Hs
		666119 NTRK2_HUMAN (1-822): 0: 638: 100.00		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Hs
		1083874 NTRK2_HUMAN (1-822): 0: 638: 100.00		SHC3_HUMAN (24-621): 5.09e-140: 422: 42.88
+	Rn
		1129187 NTRK2_RAT (1-822): 0: 622: 93.55		SHC1_RAT (148-620): 1.16e-130: 394: 49.38
+	Hs
		666117 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Hs
		607889 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		SHC1_HUMAN (26-620): 6.45e-150: 447: 45.40
+	Hs
		209065 NTRK2_HUMAN (1-822): 0: 638: 100.00		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Hs
		557707 NTRK2_HUMAN (1-822): 0: 638: 100.00		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Rn
		71362 NTRK2_RAT (1-822): 0: 622: 93.55		B2RZ33_RAT (425-615): 6.64e-40: 151: 17.35
+	Hs
		655389 NTRK2_HUMAN (1-822): 0: 638: 100.00		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		924603 NTRK2_HUMAN (1-822): 0: 638: 100.00		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48
+	Hs
		607978 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		SHB_HUMAN (356-617): 5.99e-44: 166: 20.73
+	Hs
		562650 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		PLCG2_HUMAN (269-630): 5.78e-40: 159: 13.88
+	Hs
		209063 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Hs
		208993 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Hs
		557705 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Hs
		557606 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Hs
		655387 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		607886 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		924601 NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48
+	Hs
		607935 FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48