Protein: PHA4
Defective pharyngeal development protein 4 (Ce-fkh-1) (Fork head-HNF-3 homolog)

Gene: PHA4, pha-4
Organism: Caenorhabditis elegans
Interactions: 91
UniProt ID: Q17381

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0008340 - determination of adult lifespan

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

195801

FOXO
Forkhead box protein O

1

20

High-throughput

0.656

High

116576

H8ESF3
SWI/SNF complex subunit SMARCC2

2

3

High-throughput

0.543

High

1083479

FOX1
Sex determination protein fox-1

1

5

High-throughput

0.541

High

1164746

NFIL3
Transcription factor atf-2

1

4

High-throughput

0.541

High

111322

G5ED20
RING-type domain-containing protein

1

0

High-throughput

0.518

High

1164769

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.518

High

84478

ELT3
Transcription factor elt-3

1

11

High-throughput

0.508

High

107665

APTF2
Transcription factor aptf-2

1

2

High-throughput

0.508

High

110442

LIM7
LIM/homeobox protein lim-7

1

7

High-throughput

0.508

High

113769

HIF1
Hypoxia-inducible factor 1

1

7

High-throughput

0.508

High

114023

ELT6
Transcription factor elt-6

1

11

High-throughput

0.508

High

115136

HAM2
Zinc finger protein ham-2

1

7

High-throughput

0.508

High

145839

O02273
C2H2-type domain-containing protein

1

2

High-throughput

0.508

High

195931

NFYC1
Nuclear transcription factor Y subunit nfyc-1

1

7

High-throughput

0.508

High

196309

EYA1
Protein phosphatase eya-1

1

1

High-throughput

0.508

High

196828

MAB3
Protein male abnormal 3

1

4

High-throughput

0.508

High

234154

NHR49
Nuclear hormone receptor family member nhr-49

1

20

High-throughput

0.508

High

478971

MEC3
Mechanosensory protein 3

1

7

High-throughput

0.508

High

758631

ZTF30
Zinc finger transcription factor family protein 30

1

5

High-throughput

0.508

High

759430

FOZI1
Formin-homology and zinc finger domains protein 1

1

2

High-throughput

0.508

High

759824

HM23
Homeobox protein ceh-23

1

20

High-throughput

0.508

High

760202

TRA1
Sex-determining transformer protein 1

1

2

High-throughput

0.508

High

836235

NHR23
Nuclear hormone receptor family member nhr-23

1

20

High-throughput

0.508

High

836734

HM22
Homeobox protein ceh-22

1

20

High-throughput

0.508

High

1068106

NHR22
Nuclear hormone receptor family member nhr-22

1

12

High-throughput

0.508

High

1164734

HLH26
Helix-loop-helix protein 26

1

3

High-throughput

0.508

High

1164735

Q18056
BHLH domain-containing protein

1

3

High-throughput

0.508

High

1164736

NHR31
Nuclear hormone receptor family member nhr-31

1

20

High-throughput

0.508

High

1164738

HM43
Homeobox protein ceh-43

1

20

High-throughput

0.508

High

1164740

Q18624
SAND domain-containing protein

1

5

High-throughput

0.508

High

1164743

UNC98
Zinc finger protein unc-98

1

1

High-throughput

0.508

High

1164744

ZTF2
Zinc finger protein ztf-2

1

2

High-throughput

0.508

High

1164747

EGL43
Zinc finger protein egl-43

1

5

High-throughput

0.508

High

1164748

TBX9
T-box transcription factor tbx-9

1

6

High-throughput

0.508

High

1164749

TBX8
T-box transcription factor tbx-8

1

6

High-throughput

0.508

High

1164750

EGL13
Transcription factor egl-13

1

20

High-throughput

0.508

High

1164753

NFI1
Nuclear factor I family protein

1

20

High-throughput

0.508

High

1164762

SEM2
Transcription factor sem-2

1

20

High-throughput

0.508

High

1164764

PIE1
Pharynx and intestine in excess protein 1

1

1

High-throughput

0.508

High

1164765

UNC62
Homeobox protein unc-62

1

7

High-throughput

0.508

High

1164767

NHR5
Nuclear hormone receptor family member nhr-5

1

20

High-throughput

0.508

High

1164770

Q9TXN8
DM domain-containing protein

1

4

High-throughput

0.508

High

1164775

NHR85
Nuclear hormone receptor family member nhr-85

1

20

High-throughput

0.508

High

1164778

NHR8
Nuclear hormone receptor family member nhr-8

1

20

High-throughput

0.508

High

1164752

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.494

High

1164760

Q8ITV6
FHA domain-containing protein

1

1

High-throughput

0.494

High

1019817

P92004
Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein

1

2

High-throughput

0.494

High

144760

O01527
C2H2-type domain-containing protein

1

0

High-throughput

0.486

High

196014

NFYB1
Nuclear transcription factor Y subunit nfyb-1

1

0

High-throughput

0.486

High

857281

BZIP8
bZIP transcription factor 8

1

0

High-throughput

0.486

High

1164737

FLH2
FLYWCH transcription factor 2

1

0

High-throughput

0.486

High

1164774

ZIP3
Transcription factor zip-3

1

0

High-throughput

0.486

High

73521

B2D6P5
Interferon regulatory factor 2-binding protein 1 & 2 zinc finger domain-containing protein

1

2

High-throughput

0.481

High

92572

D3YT85
DM domain-containing protein

1

1

High-throughput

0.481

High

1164755

Q7KX66
Nuclear receptor domain-containing protein

1

20

High-throughput

0.481

High

1164757

Q86G94
RRM domain-containing protein

1

7

High-throughput

0.481

High

1164758

Q86G95
Transcription factor CBF/NF-Y/archaeal histone domain-containing protein

1

12

High-throughput

0.481

High

1164759

Q86PI8
Nuclear receptor NHR-114

1

20

High-throughput

0.481

High

1164739

Q18426
TPR_REGION domain-containing protein

1

7

High-throughput

0.464

High

1164768

Q9NAE4
BZIP domain-containing protein

1

8

High-throughput

0.464

High

47221

FPEB1
FLYWCH-type zinc finger-containing protein peb-1

1

1

High-throughput

0.457

High

111161

JUN
Transcription factor jun-1

1

6

High-throughput

0.457

High

112624

NH114
Nuclear hormone receptor 114

1

20

High-throughput

0.457

High

112860

G5EEW7
RNA-binding protein ASD-1

1

8

High-throughput

0.457

High

113022

G5EF87
SWI/SNF complex subunit SMARCC2

1

17

High-throughput

0.457

High

115442

H2KZA1
Nuclear hormone receptor E75

1

20

High-throughput

0.457

High

115713

ZTF16
Zinc finger protein ztf-16

1

7

High-throughput

0.457

High

264069

O62159
DM domain-containing protein

1

1

High-throughput

0.457

High

1164745

Q20237
Transcription factor CBF/NF-Y/archaeal histone domain-containing protein

1

7

High-throughput

0.457

High

1164754

EHN3
Zinc finger protein ehn-3

1

3

High-throughput

0.457

High

1164766

LSY2
Zinc finger protein lsy-2

1

3

High-throughput

0.457

High

898271

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.451

High

1164742

Q18937
RRM domain-containing protein

1

4

High-throughput

0.451

High

1164751

Q23158
Alpha-actinin, sarcomeric

1

1

High-throughput

0.451

High

86649

B9WRT8
C3H1-type domain-containing protein

1

1

High-throughput

0.439

High

90584

C1P629
RRM domain-containing protein

1

2

High-throughput

0.439

High

116195

H2L2C8
Alpha-actinin, sarcomeric

1

1

High-throughput

0.439

High

1164756

Q86DC0
SAM domain-containing protein

1

1

High-throughput

0.439

High

145875

O02289
C3H1-type domain-containing protein

1

1

High-throughput

0.417

High

1164741

Q18662
Caskin-2

1

5

High-throughput

0.417

High

1164761

Q8ITV7
FHA domain-containing protein

1

1

High-throughput

0.417

High

144781

ASP6
Aspartic protease 6

1

0

High-throughput

0.282

High

870577

RS3A
Small ribosomal subunit protein eS1

1

0

High-throughput

0.282

High

1164773

Q9U1X3
MEiosis-to-MItosis transition associated

1

0

High-throughput

0.282

High

1164777

Q9XVM0
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.282

High

111042

G5ECP6
C2H2-type domain-containing protein

1

0

High-throughput

0.265

Low

1164763

Q93520
AAA domain-containing protein

1

0

High-throughput

0.265

Low

1164771

Q9TZ37
ZSWIM3 N-terminal domain-containing protein

1

0

High-throughput

0.265

Low

1164776

MOE3
CCCH-type zinc finger protein moe-3

1

0

High-throughput

0.265

Low

1019419

LST1
Lateral signaling target 1 protein

1

0

High-throughput

0.257

Low

1164772

Q9U1S2
Bypass of Response to Pheromone in yeast

1

0

High-throughput

0.257

Low


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Last updated: 11Aug2025