HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: SMUF1 (Q9HCE7)
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
Gene: SMURF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34662580, 23184937
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 757
+	Hs
		1084573 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125492 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		846873 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		SMUF2_HUMAN (1-757): 0: 794: 70.72
+	Hs
		808144 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		NEDD4_HUMAN (93-755): 0: 673: 36.63
+	Hs
		1235773 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125259 SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125581 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125260 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		516643 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		ITCH_HUMAN (1-757): 0: 733: 31.28
+	Hs
		125430 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125122 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125274 SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125061 SC24D_HUMAN (131-353): 2.02e-11: 68.8: 21.49		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Hs
		125687 DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59		WWP2_HUMAN (97-757): 0: 708: 36.69
+	Mm
		1208066 DIDO1_MOUSE (151-446): 1.18e-09: 63.3: 17.16		WWP2_MOUSE (97-757): 0: 702: 36.69
+	Sc
		376913 PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96		TOM1_YEAST (267-756): 5.63e-161: 518: 33.94
+	Hs
		1084614 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		1235798 CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		1311993 DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59		WWP1_HUMAN (2-395): 1.65e-27: 121: 14.94
+	Hs
		1312007 DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59		HECW2_HUMAN (1-322): 1.89e-15: 82.9: 14.87