Protein: PWP2
Periodic tryptophan protein 2 (U three protein 1) (U3 small nucleolar RNA-associated protein 1) (U3 snoRNA-associated protein 1)

Gene: PWP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 202
UniProt ID: P25635

Gene Ontology (top 5):
GO:0000028 - ribosomal small subunit assembly
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678461

UTP21
U3 small nucleolar RNA-associated protein 21

16

17

Small-scale

0.987

High

678400

UTP18
U3 small nucleolar RNA-associated protein 18

14

2

Small-scale

0.983

High

678460

UTP13
U3 small nucleolar RNA-associated protein 13

13

18

Small-scale

0.981

High

678486

UTP12
U3 small nucleolar RNA-associated protein 12

11

17

Small-scale

0.981

High

678451

DHR1
Probable ATP-dependent RNA helicase DHR1

8

10

Small-scale

0.966

High

678395

UTP7
U3 small nucleolar RNA-associated protein 7

7

19

Small-scale

0.962

High

678452

UTP15
U3 small nucleolar RNA-associated protein 15

7

20

Small-scale

0.962

High

678470

UTP4
U3 small nucleolar RNA-associated protein 4

7

19

Small-scale

0.962

High

678378

DCA13
Protein SOF1

6

20

Small-scale

0.945

High

678467

RRP9
Ribosomal RNA-processing protein 9

6

20

High-throughput

0.945

High

678444

UTP17
NET1-associated nuclear protein 1

6

18

Small-scale

0.940

High

678448

HAS1
ATP-dependent RNA helicase HAS1

6

20

High-throughput

0.928

High

632627

DBP4
ATP-dependent RNA helicase HCA4

3

17

High-throughput

0.855

High

678385

DBP8
ATP-dependent RNA helicase DBP8

3

14

High-throughput

0.855

High

678411

ROK1
ATP-dependent RNA helicase ROK1

3

12

High-throughput

0.855

High

678425

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

6

High-throughput

0.855

High

514105

RS16B
Small ribosomal subunit protein uS9B

3

6

Small-scale

0.827

High

678450

UTP5
U3 small nucleolar RNA-associated protein 5

3

19

Small-scale

0.827

High

678376

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

3

High-throughput

0.802

High

678443

UTP6
U3 small nucleolar RNA-associated protein 6

9

2

Small-scale

0.754

High

678468

NOC4
Nucleolar complex protein 4

10

7

Small-scale

0.754

High

678383

ENP1
Essential nuclear protein 1

10

2

Small-scale

0.752

High

678438

NAT10
RNA cytidine acetyltransferase

8

2

Small-scale

0.748

High

678416

MPP10
U3 small nucleolar RNA-associated protein MPP10

7

5

Small-scale

0.747

High

585217

FBRL
rRNA 2'-O-methyltransferase fibrillarin

7

10

Small-scale

0.745

High

678380

UTP20
U3 small nucleolar RNA-associated protein 20

7

1

Small-scale

0.745

High

678410

UTP10
U3 small nucleolar RNA-associated protein 10

7

5

High-throughput

0.745

High

678428

UTP22
U3 small nucleolar RNA-associated protein 22

7

3

Small-scale

0.745

High

678431

UTP8
U3 small nucleolar RNA-associated protein 8

7

1

Small-scale

0.745

High

678440

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

7

3

Small-scale

0.745

High

419622

H2A2
Histone H2A.2

3

7

High-throughput

0.742

High

677300

KRR1
KRR1 small subunit processome component

6

2

Small-scale

0.732

High

678391

UTP9
U3 small nucleolar RNA-associated protein 9

6

1

High-throughput

0.732

High

678480

BMS1
Ribosome biogenesis protein BMS1

6

7

High-throughput

0.732

High

678491

NOP58
Nucleolar protein 58

6

11

Small-scale

0.732

High

678457

RRP5
rRNA biogenesis protein RRP5

6

11

Small-scale

0.730

High

678373

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

5

9

Small-scale

0.716

High

678381

RL1D1
Ribosome biogenesis protein UTP30

5

7

Small-scale

0.716

High

678465

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

5

1

Small-scale

0.716

High

678492

RRP12
Ribosomal RNA-processing protein 12

5

3

Small-scale

0.714

High

678418

NOL10
Ribosome biogenesis protein ENP2

5

3

Small-scale

0.712

High

678469

BFR2
Protein BFR2

5

3

Small-scale

0.712

High

678479

UTP16
U3 small nucleolar RNA-associated protein 16

5

1

Small-scale

0.712

High

678379

UTP11
U3 small nucleolar RNA-associated protein 11

5

1

High-throughput

0.703

High

678498

PNO1
Pre-rRNA-processing protein PNO1

4

1

Small-scale

0.697

High

678489

NOP56
Nucleolar protein 56

4

11

High-throughput

0.697

High

678364

RS5
Small ribosomal subunit protein uS7

4

2

Small-scale

0.694

High

678366

RS7A
Small ribosomal subunit protein eS7A

4

3

Small-scale

0.694

High

383548

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.691

High

570216

RS17B
Small ribosomal subunit protein eS17B

1

2

High-throughput

0.691

High

678497

NOP14
Nucleolar complex protein 14

4

3

High-throughput

0.691

High

678396

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

4

1

Small-scale

0.688

High

381904

H4
Histone H4

2

7

High-throughput

0.679

High

678434

ESF2
Pre-rRNA-processing protein ESF2

4

2

Small-scale

0.678

High

673144

RRP7
Ribosomal RNA-processing protein 7

4

1

Small-scale

0.676

High

149618

RS9A
Small ribosomal subunit protein uS4A

3

9

Small-scale

0.667

High

435808

RS13
Small ribosomal subunit protein uS15

3

3

Small-scale

0.667

High

678466

ESF1
Pre-rRNA-processing protein ESF1

3

1

High-throughput

0.662

High

441738

RS14A
Small ribosomal subunit protein uS11A

3

8

High-throughput

0.656

High

678404

FAF1
Protein FAF1

3

1

Small-scale

0.656

High

512024

RS4A
Small ribosomal subunit protein eS4A

3

3

Small-scale

0.640

High

512852

RS8A
Small ribosomal subunit protein eS8A

3

3

Small-scale

0.640

High

678435

CSL4
Exosome complex component CSL4

3

3

Small-scale

0.640

High

678474

RCL1
rRNA processing protein RCL1

3

1

Small-scale

0.640

High

435522

RS9B
Small ribosomal subunit protein uS4B

2

9

High-throughput

0.628

High

678408

DIM1
Dimethyladenosine transferase

3

0

High-throughput

0.628

High

502882

RS22A
Small ribosomal subunit protein uS8A

4

6

Small-scale

0.623

High

678371

MVD1
Diphosphomevalonate decarboxylase

2

1

High-throughput

0.621

High

678361

PWP2
Periodic tryptophan protein 2

1

16

High-throughput

0.618

High

678362

SPB4
ATP-dependent rRNA helicase SPB4

1

19

High-throughput

0.618

High

678414

MTR4
ATP-dependent RNA helicase DOB1

1

18

High-throughput

0.618

High

678421

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.618

High

678430

PESC
Pescadillo homolog

1

2

High-throughput

0.618

High

678436

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

15

High-throughput

0.618

High

678488

DBP10
ATP-dependent RNA helicase DBP10

1

18

High-throughput

0.618

High

678482

SAS10
Something about silencing protein 10

2

2

High-throughput

0.614

High

434869

RS3
Small ribosomal subunit protein uS3

2

8

High-throughput

0.611

High

511739

RS24A
Small ribosomal subunit protein eS24A

2

3

Small-scale

0.611

High

678369

XPO1
Exportin-1

2

13

Small-scale

0.611

High

678377

RS3A1
Small ribosomal subunit protein eS1A

2

2

High-throughput

0.611

High

678393

RS14B
Small ribosomal subunit protein uS11B

2

8

Small-scale

0.611

High

678462

MRD1
Multiple RNA-binding domain-containing protein 1

2

5

Small-scale

0.611

High

678496

RS22B
Small ribosomal subunit protein uS8B

3

6

High-throughput

0.599

High

678390

YHS2
MIP18 family protein YHR122W

1

3

High-throughput

0.590

High

678472

NOP6
Nucleolar protein 6

2

0

High-throughput

0.585

High

512291

RS6A
Small ribosomal subunit protein eS6A

2

6

Small-scale

0.584

High

513826

RS11B
Small ribosomal subunit protein uS17B

2

4

High-throughput

0.584

High

678401

RRT14
Regulator of rDNA transcription protein 14

2

1

Small-scale

0.584

High

678455

UTP14
U3 small nucleolar RNA-associated protein 14

2

4

High-throughput

0.584

High

678458

FCF1
rRNA-processing protein FCF1

2

1

Small-scale

0.584

High

678473

CMS1
Protein CMS1

2

1

High-throughput

0.584

High

678481

FCF2
rRNA-processing protein FCF2

2

2

Small-scale

0.584

High

678490

RRP36
rRNA biogenesis protein RRP36

2

1

Small-scale

0.584

High

444437

DED1
ATP-dependent RNA helicase DED1

1

8

High-throughput

0.575

High

678382

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.575

High

392317

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.571

High

569921

RL3
Large ribosomal subunit protein uL3

2

5

High-throughput

0.571

High

678454

BUD22
Bud site selection protein 22

2

2

High-throughput

0.571

High

383089

RLA4
Large ribosomal subunit protein P2B

2

1

High-throughput

0.567

High

661377

PSA3
Proteasome subunit alpha type-3

2

3

High-throughput

0.567

High

523201

HSP71
Heat shock protein SSA1

2

16

High-throughput

0.552

High

543982

SSB1
Ribosome-associated molecular chaperone SSB1

2

17

High-throughput

0.552

High

678397

SSB2
Ribosome-associated molecular chaperone SSB2

2

17

High-throughput

0.552

High

636631

PSA1
Proteasome subunit alpha type-1

2

2

High-throughput

0.537

High

678372

RML2
Large ribosomal subunit protein uL2m

2

2

High-throughput

0.537

High

678399

PSA4
Proteasome subunit alpha type-4

2

2

High-throughput

0.537

High

433154

RL17A
Large ribosomal subunit protein uL22A

1

3

High-throughput

0.536

High

655400

RS3A2
Small ribosomal subunit protein eS1B

1

2

High-throughput

0.536

High

678365

RL16B
Large ribosomal subunit protein uL13B

1

5

High-throughput

0.536

High

678409

YG4I
Uncharacterized GTP-binding protein YGR210C

1

2

High-throughput

0.536

High

513464

RL1A
Large ribosomal subunit protein uL1A

2

9

High-throughput

0.533

High

531623

RL4A
Large ribosomal subunit protein uL4A

2

6

High-throughput

0.521

High

503755

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.517

High

400057

PUR1
Amidophosphoribosyltransferase

1

1

High-throughput

0.515

High

678368

RL8B
Large ribosomal subunit protein eL8B

1

8

High-throughput

0.514

High

486056

TBA1
Tubulin alpha-1 chain

1

18

High-throughput

0.500

High

675750

MAS5
Mitochondrial protein import protein MAS5

1

11

High-throughput

0.500

High

432985

RL6B
Large ribosomal subunit protein eL6B

1

1

High-throughput

0.489

High

433978

RL33A
Large ribosomal subunit protein eL33A

1

3

High-throughput

0.489

High

434137

RL36A
Large ribosomal subunit protein eL36A

1

3

High-throughput

0.489

High

434328

RL15A
Large ribosomal subunit protein eL15A

1

3

High-throughput

0.489

High

678398

RL13B
Large ribosomal subunit protein eL13B

1

2

High-throughput

0.489

High

678426

RL26B
Large ribosomal subunit protein uL24B

1

6

High-throughput

0.489

High

678494

RL11B
Large ribosomal subunit protein uL5B

1

3

High-throughput

0.489

High

678419

GTO1
Glutathione S-transferase omega-like 1

1

0

High-throughput

0.486

High

511635

RS23B
Small ribosomal subunit protein uS12B

1

1

Small-scale

0.479

High

514488

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

647022

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

672856

RRP43
Exosome complex component RRP43

1

1

High-throughput

0.479

High

678363

RL5
Large ribosomal subunit protein uL18

1

3

Small-scale

0.479

High

678370

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

678374

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

678384

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

678386

CIC1
Proteasome-interacting protein CIC1

1

7

High-throughput

0.479

High

678388

RRP4
Exosome complex component RRP4

1

7

High-throughput

0.479

High

678389

LRP1
Exosome complex protein LRP1

1

1

High-throughput

0.479

High

678392

RRP8
25S rRNA

1

3

High-throughput

0.479

High

678402

UTP25
U3 small nucleolar RNA-associated protein 25

1

1

High-throughput

0.479

High

678406

RLP7
Ribosome biogenesis protein RLP7

1

6

High-throughput

0.479

High

678413

RRP41
Exosome complex component SKI6

1

19

High-throughput

0.479

High

678415

NOP9
Nucleolar protein 9

1

1

Small-scale

0.479

High

678417

URB2
Nucleolar pre-ribosomal-associated protein 2

1

1

High-throughput

0.479

High

678420

MTR3
Exosome complex component MTR3

1

1

High-throughput

0.479

High

678422

RL4B
Large ribosomal subunit protein uL4B

1

6

High-throughput

0.479

High

678427

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.479

High

678429

RRP46
Exosome complex component RRP46

1

17

High-throughput

0.479

High

678433

PXR1
Protein PXR1

1

1

Small-scale

0.479

High

678439

APJ1
J domain-containing protein APJ1

1

10

High-throughput

0.479

High

678442

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

678445

ESP1
Separin

1

1

High-throughput

0.479

High

678447

TOM1
E3 ubiquitin-protein ligase TOM1

1

9

High-throughput

0.479

High

678449

BUL2
Ubiquitin ligase-binding protein BUL2

1

2

Small-scale

0.479

High

678453

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.479

High

678459

RRP45
Exosome complex component RRP45

1

12

High-throughput

0.479

High

678463

SGD1
Suppressor of glycerol defect protein 1

1

5

High-throughput

0.479

High

678471

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

678475

RRP44
Exosome complex exonuclease DIS3

1

5

High-throughput

0.479

High

678476

BRX1
Ribosome biogenesis protein BRX1

1

5

High-throughput

0.479

High

678477

RRP40
Exosome complex component RRP40

1

3

High-throughput

0.479

High

678478

SGO1
Shugoshin

1

2

High-throughput

0.479

High

678483

RRP6
Exosome complex exonuclease RRP6

1

6

High-throughput

0.479

High

678484

MAK21
Ribosome biogenesis protein MAK21

1

7

High-throughput

0.479

High

678487

RRP42
Exosome complex component RRP42

1

12

High-throughput

0.479

High

678493

EFG1P
rRNA-processing protein EFG1

1

1

High-throughput

0.479

High

678432

NOP19
Nucleolar protein 19

1

0

Small-scale

0.458

High

678495

RS28A
Small ribosomal subunit protein eS28A

1

0

Small-scale

0.458

High

366949

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.457

High

405043

LEU3
3-isopropylmalate dehydrogenase

1

5

High-throughput

0.457

High

621344

METK2
S-adenosylmethionine synthase 2

1

2

High-throughput

0.457

High

394285

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

403377

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

High-throughput

0.445

High

427156

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.445

High

432505

RL7A
Large ribosomal subunit protein uL30A

1

6

High-throughput

0.445

High

454911

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.445

High

526044

HSP72
Heat shock protein SSA2

1

16

High-throughput

0.445

High

592048

VATB
V-type proton ATPase subunit B

1

7

High-throughput

0.445

High

670390

SIS1
Protein SIS1

1

7

High-throughput

0.445

High

671580

SCJ1
DnaJ-related protein SCJ1

1

7

High-throughput

0.445

High

678387

SSZ1
Ribosome-associated complex subunit SSZ1

1

13

High-throughput

0.445

High

678412

RSSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.445

High

678423

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.445

High

678424

IMB5
Importin subunit beta-5

1

1

High-throughput

0.445

High

678437

PFD4
Prefoldin subunit 4

1

4

High-throughput

0.445

High

678485

RL7B
Large ribosomal subunit protein uL30B

1

6

High-throughput

0.445

High

409964

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

433482

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.437

High

504067

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

513641

RL2A
Large ribosomal subunit protein uL2A

1

2

High-throughput

0.437

High

515050

RL19B
Large ribosomal subunit protein eL19

1

2

High-throughput

0.437

High

671309

CANB
Calcineurin subunit B

1

4

High-throughput

0.437

High

678367

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

678375

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

678394

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

678403

ULP2
Ubiquitin-like-specific protease 2

1

7

High-throughput

0.437

High

678405

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.437

High

678441

NUM1
Nuclear migration protein NUM1

1

12

High-throughput

0.437

High

678464

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

678446

ERO1
Endoplasmic oxidoreductin-1

2

0

High-throughput

0.324

High

425111

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.261

Low

678456

SOV1
Protein SOV1, mitochondrial

1

0

High-throughput

0.261

Low

678407

LYS14
Lysine biosynthesis regulatory protein LYS14

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025