Interactor 1: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A
Interactor 2: EGLN2 (Q96KS0)
Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)
Gene: EGLN2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.91 | 1.00 | 0.955 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 16155211, 17353276, 26644182, 18264140, 24145445, 15474027, 16511565 |
| Identification Methods | enzymatic study, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, experimental interaction detection, anti bait coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, hydroxylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | 2OG-FeII_Oxy_3~HIF-1 |
| Common GO terms | GO:0001666 - response to hypoxia GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0071456 - cellular response to hypoxia |
| Homologous interactions | 14 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
