Protein: FOXO3
Forkhead box protein O3

Gene: FOXO3
Organism: Mus musculus
Interactions: 77
UniProt ID: Q9WVH4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001221 - transcription coregulator binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

74305

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.618

High

107100

F8VPR5
histone acetyltransferase

1

20

Small-scale

0.618

High

1408718

FOXP3
Forkhead box protein P3

1

19

Small-scale

0.618

High

60026

ARI1A
AT-rich interactive domain-containing protein 1A

1

13

High-throughput

0.479

High

148212

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

465708

CBR2
Carbonyl reductase [NADPH] 2

1

1

Small-scale

0.479

High

515872

FCOR
Foxo1-corepressor

1

1

Small-scale

0.479

High

644461

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

4

High-throughput

0.479

High

663007

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.479

High

723160

CCL5
C-C motif chemokine 5

1

1

Small-scale

0.479

High

1000420

IRF7
Interferon regulatory factor 7

1

6

Small-scale

0.479

High

1000521

LDB1
LIM domain-binding protein 1

1

3

Small-scale

0.479

High

1022138

DAB2
Disabled homolog 2

1

3

High-throughput

0.479

High

1036102

CTNB1
Catenin beta-1

1

11

Small-scale

0.479

High

1060339

PLK1
Serine/threonine-protein kinase PLK1

1

14

Small-scale

0.479

High

1189541

Q3TQ10
TSC complex subunit 2

1

2

High-throughput

0.479

High

1221473

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

6

Small-scale

0.479

High

1221570

CNOT7
CCR4-NOT transcription complex subunit 7

1

2

High-throughput

0.479

High

1222567

HIF1A
Hypoxia-inducible factor 1-alpha

1

18

Small-scale

0.479

High

1225758

H2B1B
Histone H2B type 1-B

1

3

Small-scale

0.479

High

1242764

NEST
Nestin

1

13

High-throughput

0.479

High

1246352

RIGI
Antiviral innate immune response receptor RIG-I

1

9

Small-scale

0.479

High

1282974

DDHD1
Phospholipase DDHD1

1

1

Small-scale

0.479

High

1295967

U2AF4
Splicing factor U2AF 26 kDa subunit

1

2

High-throughput

0.479

High

1296557

WDR48
WD repeat-containing protein 48

1

18

High-throughput

0.479

High

1341481

CAHM5
Calcium homeostasis modulator protein 5

1

1

High-throughput

0.479

High

1341660

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

13

Small-scale

0.479

High

1354136

OAS3
2'-5'-oligoadenylate synthase 3

1

2

Small-scale

0.479

High

1354137

OASL1
2'-5'-oligoadenylate synthase-like protein 1

1

5

Small-scale

0.479

High

1408599

DHX58
ATP-dependent RNA helicase DHX58

1

20

Small-scale

0.479

High

1408819

CSTF1
Cleavage stimulation factor subunit 1

1

13

High-throughput

0.479

High

1423951

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.479

High

1423971

MRT4
mRNA turnover protein 4 homolog

1

2

Small-scale

0.479

High

1424299

TSC1
Hamartin

1

9

High-throughput

0.479

High

1424411

RDH14
Retinol dehydrogenase 14

1

2

Small-scale

0.479

High

1424428

ARHG7
Rho guanine nucleotide exchange factor 7

1

2

High-throughput

0.479

High

1490134

UBP18
Ubl carboxyl-terminal hydrolase 18

1

12

Small-scale

0.479

High

1490185

MX2
Interferon-induced GTP-binding protein Mx2

1

1

Small-scale

0.479

High

59758

SKT
Sickle tail protein

1

0

High-throughput

0.458

High

205412

NOCT
Nocturnin

1

0

Small-scale

0.458

High

617835

IL10
Interleukin-10

1

0

Small-scale

0.458

High

770793

5HT2A
5-hydroxytryptamine receptor 2A

1

0

Small-scale

0.458

High

936160

AQP4
Aquaporin-4

1

0

High-throughput

0.458

High

1062952

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.458

High

1189936

CMPK2
UMP-CMP kinase 2, mitochondrial

1

0

Small-scale

0.458

High

1190584

MCU
Calcium uniporter protein, mitochondrial

1

0

High-throughput

0.458

High

1190823

CENPW
Centromere protein W

1

0

Small-scale

0.458

High

1191036

ZN583
Zinc finger protein 583

1

0

Small-scale

0.458

High

1222600

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.458

High

1298223

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

0

Small-scale

0.458

High

1317369

IL27A
Interleukin-27 subunit alpha

1

0

Small-scale

0.458

High

1363023

SF3B5
Splicing factor 3B subunit 5

1

0

High-throughput

0.458

High

1423937

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

Small-scale

0.458

High

1424400

RTP4
Receptor-transporting protein 4

1

0

Small-scale

0.458

High

1424409

NUSAP
Nucleolar and spindle-associated protein 1

1

0

Small-scale

0.458

High

1455897

ZBP1
Z-DNA-binding protein 1

1

0

Small-scale

0.458

High

98182

E9Q6E5
Serine and arginine-rich splicing factor 11

1

2

High-throughput

0.437

High

98333

E9QLJ0
Cardiomyopathy-associated protein 5

1

5

High-throughput

0.437

High

204883

EDIL3
EGF-like repeat and discoidin I-like domain-containing protein 3

1

3

Small-scale

0.437

High

555569

FGL2
Fibroleukin

1

4

Small-scale

0.437

High

715016

FETUA
Alpha-2-HS-glycoprotein

1

1

High-throughput

0.437

High

954664

GPR85
Probable G-protein coupled receptor 85

1

1

Small-scale

0.437

High

1189950

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.437

High

1190398

Q3UKG2
Proline rich basic protein 1

1

11

High-throughput

0.437

High

1190791

FCHO2
F-BAR domain only protein 2

1

2

High-throughput

0.437

High

1223913

SN
Sialoadhesin

1

2

Small-scale

0.437

High

1298714

SMTL2
Smoothelin-like protein 2

1

4

High-throughput

0.437

High

1341579

IF27A
Interferon alpha-inducible protein 27-like protein 2A

1

1

Small-scale

0.437

High

1440900

Q9JL91
Nebulin

1

2

High-throughput

0.437

High

1490186

OASL2
2'-5'-oligoadenylate synthase-like protein 2

1

5

Small-scale

0.437

High

313032

RPP30
Ribonuclease P protein subunit p30

1

0

High-throughput

0.249

Low

641481

CD72
B-cell differentiation antigen CD72

1

0

Small-scale

0.249

Low

947401

STAR6
StAR-related lipid transfer protein 6

1

0

Small-scale

0.249

Low

1054098

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.249

Low

1208425

FBX39
F-box only protein 39

1

0

Small-scale

0.249

Low

1282811

BANK1
B-cell scaffold protein with ankyrin repeats

1

0

Small-scale

0.249

Low

1490184

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025