HitPredict

Interactor 1: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Interactor 2: UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	24813945, 30104358, 29395786, 23281010, 26065575, 27595565, 22100450, 23161542, 23752590
Identification Methods	unspecified method, pull down, enzymatic study, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Histone~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 793
+	Hs
		935151 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		UHRF1_HUMAN (1-793): 0: 893: 100.00
+	Xl
		78543 Q92133_XENLA (1-136): 5.83e-61: 185: 96.32		UHRF1_XENLA (1-793): 0: 806: 66.00
+	Hs
		935136 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		UHRF2_HUMAN (1-793): 0: 774: 53.01
+	At
		886462 H33_ARATH (1-136): 1.13e-61: 187: 93.38		SUVH4_ARATH (382-642): 2.2e-60: 217: 28.21
+	Hs
		935016 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		CHD5_HUMAN (233-502): 9.75e-55: 207: 18.61
+	Hs
		1086233 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		CHD5_HUMAN (233-502): 9.75e-55: 207: 18.61
+	Hs
		934705 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90
+	Hs
		934770 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		1059646 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		935347 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		BAZ2A_HUMAN (138-417): 1.39e-38: 157: 17.87
+	Hs
		935339 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		KDM5B_HUMAN (227-383): 6.15e-32: 136: 20.35
+	Hs
		1086304 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		KDM5D_HUMAN (227-383): 2.19e-27: 121: 19.00
+	Hs
		666522 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		KDM5A_HUMAN (274-383): 9.75e-20: 97.2: 27.27
+	At
		886465 H33_ARATH (1-136): 1.13e-61: 187: 93.38		ATXR5_ARATH (278-414): 1.32e-20: 96.5: 19.74
+	Hs
		666535 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		KDM5A_HUMAN (274-383): 9.75e-20: 97.2: 27.27
+	Hs
		1086335 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		PHRF1_HUMAN (318-423): 2.27e-19: 96.1: 32.50
+	Hs
		935064 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		DPF3_HUMAN (310-374): 1.48e-18: 90.3: 37.88
+	Hs
		1086251 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		DPF3_HUMAN (310-374): 1.48e-18: 90.3: 37.88
+	At
		886470 H33_ARATH (1-136): 1.13e-61: 187: 93.38		ATXR6_ARATH (292-416): 2.87e-18: 89.1: 26.32
+	Hs
		152625 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		KMT2D_HUMAN (313-363): 2.86e-11: 69.9: 48.08