Protein: NUMB
Protein numb homolog (h-Numb) (Protein S171)

Gene: NUMB
Organism: Homo sapiens
Interactions: 213
UniProt ID: P49757

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005769 - early endosome
GO:0005886 - plasma membrane
GO:0005905 - clathrin-coated pit
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

833629

LNX1
E3 ubiquitin-protein ligase LNX

4

19

Small-scale

0.906

High

833625

LNX2
Ligand of Numb protein X 2

3

18

Small-scale

0.828

High

394340

A4
Amyloid-beta precursor protein

2

15

High-throughput

0.789

High

833590

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

3

High-throughput

0.743

High

386315

P53
Cellular tumor antigen p53

6

1

Small-scale

0.735

High

833578

MDM2
E3 ubiquitin-protein ligase Mdm2

11

0

Small-scale

0.726

High

833639

AP2M1
AP-2 complex subunit mu

5

6

Small-scale

0.716

High

787868

EPS15
Epidermal growth factor receptor substrate 15

4

18

Small-scale

0.692

High

833676

NUMBL
Numb-like protein

1

4

High-throughput

0.691

High

833642

ITCH
E3 ubiquitin-protein ligase Itchy homolog

3

2

Small-scale

0.680

High

262397

TULP3
Tubby-related protein 3

3

2

High-throughput

0.667

High

833572

AP2B1
AP-2 complex subunit beta

3

20

Small-scale

0.650

High

338128

EGFR
Epidermal growth factor receptor

3

20

Small-scale

0.646

High

833619

SIAH1
E3 ubiquitin-protein ligase SIAH1

2

5

Small-scale

0.646

High

349976

RASK
GTPase KRas

3

18

High-throughput

0.640

High

683205

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.635

High

833566

1433G
14-3-3 protein gamma

2

20

High-throughput

0.635

High

833567

1433E
14-3-3 protein epsilon

2

3

High-throughput

0.635

High

833620

UN5CL
UNC5C-like protein

2

1

High-throughput

0.628

High

808047

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

2

Small-scale

0.624

High

833624

PALS1
Protein PALS1

1

8

High-throughput

0.621

High

321513

AP2A1
AP-2 complex subunit alpha-1

2

20

Small-scale

0.619

High

150911

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

17

High-throughput

0.618

High

833554

AFAD
Afadin

1

20

High-throughput

0.618

High

833631

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.618

High

451394

CLCA
Clathrin light chain A

2

7

High-throughput

0.611

High

451651

CLCB
Clathrin light chain B

2

7

High-throughput

0.611

High

833573

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

833586

KPCZ
Protein kinase C zeta type

1

11

Small-scale

0.608

High

804170

NOTC1
Neurogenic locus notch homolog protein 1

2

8

Small-scale

0.602

High

833587

AP1B1
AP-1 complex subunit beta-1

2

20

Small-scale

0.601

High

566327

KPCA
Protein kinase C alpha type

2

11

Small-scale

0.595

High

833655

DNJC5
DnaJ homolog subfamily C member 5

2

3

High-throughput

0.595

High

207302

FRS3
Fibroblast growth factor receptor substrate 3

2

3

High-throughput

0.594

High

724522

IRS1
Insulin receptor substrate 1

2

5

High-throughput

0.594

High

349190

RASH
GTPase HRas

2

13

High-throughput

0.584

High

506926

LAMP1
Lysosome-associated membrane glycoprotein 1

2

5

High-throughput

0.584

High

546980

EZRI
Ezrin

2

5

High-throughput

0.584

High

591770

RAB4A
Ras-related protein Rab-4A

2

5

High-throughput

0.584

High

833560

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.584

High

833569

RB11A
Ras-related protein Rab-11A

2

4

High-throughput

0.584

High

833570

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

833633

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

5

High-throughput

0.574

High

369194

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

833597

RBP1
RalA-binding protein 1

2

3

Small-scale

0.571

High

833664

BMP2K
BMP-2-inducible protein kinase

2

6

Small-scale

0.571

High

436686

GLI1
Zinc finger protein GLI1

1

3

Small-scale

0.561

High

809215

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

15

Small-scale

0.561

High

833558

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

Small-scale

0.561

High

833602

DPYL2
Dihydropyrimidinase-related protein 2

1

2

Small-scale

0.561

High

833585

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

833627

OLIG1
Oligodendrocyte transcription factor 1

2

2

High-throughput

0.542

High

161634

GAK
Cyclin-G-associated kinase

1

10

High-throughput

0.536

High

496568

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.536

High

716876

CTNB1
Catenin beta-1

1

1

Small-scale

0.536

High

792747

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.536

High

833564

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.536

High

833577

CLH1
Clathrin heavy chain 1

1

4

High-throughput

0.536

High

833591

PKD2
Polycystin-2

1

1

High-throughput

0.536

High

833604

DREB
Drebrin

1

4

High-throughput

0.536

High

833640

REPS1
RalBP1-associated Eps domain-containing protein 1

1

20

Small-scale

0.536

High

833659

PAAT
ATPase PAAT

1

2

High-throughput

0.536

High

833663

ANLN
Anillin

1

3

High-throughput

0.536

High

833599

TERF2
Telomeric repeat-binding factor 2

2

1

High-throughput

0.526

High

759939

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.518

High

499624

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.515

High

274961

RENR
Renin receptor

1

0

High-throughput

0.513

High

503686

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

833575

IGBP1
Immunoglobulin-binding protein 1

1

0

High-throughput

0.513

High

833661

BEX1
Protein BEX1

1

0

High-throughput

0.513

High

833666

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.513

High

408578

KPCB
Protein kinase C beta type

1

11

Small-scale

0.501

High

833582

KPCE
Protein kinase C epsilon type

1

11

Small-scale

0.501

High

833673

FBW1A
F-box/WD repeat-containing protein 1A

1

5

Small-scale

0.500

High

661220

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

812961

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.489

High

833612

SPSB3
SPRY domain-containing SOCS box protein 3

1

6

High-throughput

0.489

High

833630

ZCH10
Zinc finger CCHC domain-containing protein 10

1

2

High-throughput

0.489

High

833634

SPRY4
SPRY domain-containing protein 4

1

3

High-throughput

0.489

High

833665

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.489

High

833670

KLH21
Kelch-like protein 21

1

5

High-throughput

0.489

High

833674

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

48296

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

120348

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

160449

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

162515

XPO1
Exportin-1

1

5

High-throughput

0.479

High

178435

STX7
Syntaxin-7

1

4

High-throughput

0.479

High

205177

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

212762

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

279481

FLOT1
Flotillin-1

1

4

High-throughput

0.479

High

318083

DIRA3
GTP-binding protein Di-Ras3

1

5

High-throughput

0.479

High

348573

RASN
GTPase NRas

1

18

High-throughput

0.479

High

373886

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.479

High

411643

LCK
Tyrosine-protein kinase Lck

1

15

High-throughput

0.479

High

433649

LYN
Tyrosine-protein kinase Lyn

1

16

High-throughput

0.479

High

434160

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.479

High

435585

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.479

High

436206

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

443396

VIME
Vimentin

1

4

Small-scale

0.479

High

521808

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

527350

LAMP2
Lysosome-associated membrane glycoprotein 2

1

5

High-throughput

0.479

High

545266

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

564452

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

566974

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

577001

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

4

High-throughput

0.479

High

591524

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.479

High

592158

RAB5A
Ras-related protein Rab-5A

1

6

High-throughput

0.479

High

607918

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

646726

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

665562

EPHB2
Ephrin type-B receptor 2

1

14

High-throughput

0.479

High

669928

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

High-throughput

0.479

High

674364

UFO
Tyrosine-protein kinase receptor UFO

1

14

Small-scale

0.479

High

683906

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

685305

L1CAM
Neural cell adhesion molecule L1

1

2

Small-scale

0.479

High

716628

CTNA1
Catenin alpha-1

1

1

Small-scale

0.479

High

787418

MTOR
Serine/threonine-protein kinase mTOR

1

2

Small-scale

0.479

High

793234

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.479

High

808400

YAP1
Transcriptional coactivator YAP1

1

4

High-throughput

0.479

High

817796

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.479

High

833547

VASP
Vasodilator-stimulated phosphoprotein

1

5

High-throughput

0.479

High

833548

RAB5C
Ras-related protein Rab-5C

1

6

High-throughput

0.479

High

833549

RAB9A
Ras-related protein Rab-9A

1

8

High-throughput

0.479

High

833550

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

833552

EPHA5
Ephrin type-A receptor 5

1

18

High-throughput

0.479

High

833553

EPHA4
Ephrin type-A receptor 4

1

17

High-throughput

0.479

High

833556

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.479

High

833559

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

833562

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

833563

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

833568

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

833571

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

833574

CXAR
Coxsackievirus and adenovirus receptor

1

3

High-throughput

0.479

High

833576

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

833580

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.479

High

833581

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

833583

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

833588

STX4
Syntaxin-4

1

4

High-throughput

0.479

High

833593

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

833596

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.479

High

833598

EPHA7
Ephrin type-A receptor 7

1

14

High-throughput

0.479

High

833600

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

833601

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.479

High

833603

OCLN
Occludin

1

3

High-throughput

0.479

High

833605

AAK1
AP2-associated protein kinase 1

1

8

High-throughput

0.479

High

833609

RNF43
E3 ubiquitin-protein ligase RNF43

1

3

High-throughput

0.479

High

833610

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

833613

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

833614

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

833616

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

3

High-throughput

0.479

High

833621

RPTOR
Regulatory-associated protein of mTOR

1

4

Small-scale

0.479

High

833622

CXD3
Gap junction delta-3 protein

1

6

High-throughput

0.479

High

833632

SMAP2
Stromal membrane-associated protein 2

1

7

High-throughput

0.479

High

833635

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

833637

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

833644

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

833645

FMNL2
Formin-like protein 2

1

1

High-throughput

0.479

High

833647

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

833648

LST8
Target of rapamycin complex subunit LST8

1

3

Small-scale

0.479

High

833649

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

833652

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

High-throughput

0.479

High

833653

WWTR1
WW domain-containing transcription regulator protein 1

1

4

High-throughput

0.479

High

833654

TRPV6
Transient receptor potential cation channel subfamily V member 6

1

2

Small-scale

0.479

High

833656

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

833657

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

833660

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

833662

E41LA
Band 4.1-like protein 4A

1

4

High-throughput

0.479

High

833669

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

833671

ALK
ALK tyrosine kinase receptor

1

19

High-throughput

0.479

High

833672

LAMP3
Lysosome-associated membrane glycoprotein 3

1

5

High-throughput

0.479

High

49001

SHOT1
Shootin-1

1

0

Small-scale

0.458

High

833646

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

833651

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

833658

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

302120

AP2A2
AP-2 complex subunit alpha-2

1

20

Small-scale

0.445

High

833551

AP2S1
AP-2 complex subunit sigma

1

7

Small-scale

0.445

High

833555

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

18

High-throughput

0.445

High

833579

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

833650

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

833668

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

18

Small-scale

0.445

High

833643

EAF1
ELL-associated factor 1

1

1

High-throughput

0.439

High

169408

BET1
BET1 homolog

1

4

High-throughput

0.437

High

171204

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.437

High

305387

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

379130

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.437

High

833561

RAB2A
Ras-related protein Rab-2A

1

5

High-throughput

0.437

High

833565

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.437

High

833594

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.437

High

833595

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.437

High

833615

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.437

High

833617

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.437

High

833626

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.437

High

833628

DPTOR
DEP domain-containing mTOR-interacting protein

1

1

Small-scale

0.437

High

833636

ESR2
Estrogen receptor beta

1

10

High-throughput

0.437

High

833638

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.437

High

717564

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.407

High

833607

BTBD8
BTB/POZ domain-containing protein 8

1

8

High-throughput

0.407

High

833611

PKHA7
Pleckstrin homology domain-containing family A member 7

1

9

High-throughput

0.407

High

833641

STALP
AMSH-like protease

2

0

High-throughput

0.328

High

833557

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.279

Low

833584

COAA1

1

0

High-throughput

0.279

Low

833592

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.279

Low

833623

CT197
Putative uncharacterized protein encoded by LINC02910

1

0

High-throughput

0.279

Low

833675

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

833589

PDZ1I
PDZK1-interacting protein 1

1

0

High-throughput

0.251

Low

833606

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

0

High-throughput

0.251

Low

132433

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

296700

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.249

Low

650671

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

719969

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

825352

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

833608

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

833618

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

833667

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024