HitPredict

Interactor 1: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Interactor 2: SETD2 (Q9BYW2)
Histone-lysine N-methyltransferase SETD2 (EC 2.1.1.359) (HIF-1) (Huntingtin yeast partner B) (Huntingtin-interacting protein 1) (HIP-1) (Huntingtin-interacting protein B) (Lysine N-methyltransferase 3A) (Protein-lysine N-methyltransferase SETD2) (EC 2.1.1.-) (SET domain-containing protein 2) (hSET2) (p231HBP)
Gene: SETD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24412544
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 2564
+	Hs
		935204 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		SETD2_HUMAN (1-2564): 0: 3956: 100.00
+	Hs
		203659 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		SUV91_HUMAN (1370-1689): 2.66e-92: 308: 23.66
+	Hs
		203664 H33_HUMAN (1-136): 4.53e-61: 185: 93.38		SUV91_HUMAN (1370-1689): 2.66e-92: 308: 23.66
+	Hs
		331780 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		935205 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		NSD3_HUMAN (1410-1728): 2.45e-77: 287: 31.33
+	Hs
		1086307 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		NSD3_HUMAN (1410-1728): 2.45e-77: 287: 31.33
+	Hs
		331823 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		NSD2_HUMAN (1441-1728): 1.87e-77: 287: 34.45
+	Hs
		935129 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		NSD1_HUMAN (1458-1727): 5.38e-73: 275: 32.73
+	Hs
		1086280 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		NSD1_HUMAN (1458-1727): 5.38e-73: 275: 32.73
+	Hs
		935251 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		EHMT1_HUMAN (1432-1726): 8.57e-72: 268: 24.38
+	Hs
		1086320 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		EHMT1_HUMAN (1432-1726): 8.57e-72: 268: 24.38
+	Hs
		935276 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		ASH1L_HUMAN (1334-1793): 2.85e-70: 266: 25.90
+	Hs
		935237 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		SUV92_HUMAN (1420-1689): 3.06e-77: 265: 23.13
+	Hs
		935126 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		EHMT2_HUMAN (1443-1686): 2.36e-66: 250: 25.28
+	Hs
		1086279 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		EHMT2_HUMAN (1443-1686): 2.36e-66: 250: 25.28
+	Mm
		952777 H33_MOUSE (1-136): 4.53e-61: 185: 93.38		EHMT2_MOUSE (1443-1686): 6.26e-66: 249: 25.28
+	Hs
		934804 H31_HUMAN (1-136): 6.88e-62: 187: 97.06		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Hs
		1079993 H31T_HUMAN (1-136): 2.65e-61: 186: 100.00		EZH2_HUMAN (1539-1670): 4.47e-17: 90.1: 36.36
+	Mm
		952747 H33_MOUSE (1-136): 4.53e-61: 185: 93.38		EZH2_MOUSE (1539-1670): 3.93e-17: 90.5: 36.36
+	Mm
		952754 H33_MOUSE (1-136): 4.53e-61: 185: 93.38		Q6AXH7_MOUSE (1539-1670): 3.81e-17: 90.5: 36.36