HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: C2D1B (Q5T0F9)
Coiled-coil and C2 domain-containing protein 1B (Five prime repressor element under dual repression-binding protein 2) (FRE under dual repression-binding protein 2) (Freud-2)
Gene: CC2D1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 858
+	Hs
		1132379 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		C2D1B_HUMAN (1-858): 1.67e-144: 449: 100.00
+	Hs
		1132382 H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03		C2D1B_HUMAN (1-858): 1.67e-144: 449: 100.00
+	Hs
		1158633 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		C2D1A_HUMAN (6-855): 1.16e-100: 336: 42.47
+	Hs
		1274409 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		ASPP1_HUMAN (111-544): 5.73e-21: 100: 12.85
+	Hs
		1056847 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		MDC1_HUMAN (5-610): 3.28e-14: 79.4: 8.40
+	Hs
		1056919 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		MDC1_HUMAN (5-610): 3.28e-14: 79.4: 8.40
+	Hs
		918364 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		MDC1_HUMAN (5-610): 3.28e-14: 79.4: 8.40
+	Hs
		707631 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		MDC1_HUMAN (5-610): 3.28e-14: 79.4: 8.40
+	Hs
		918533 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		KMT2C_HUMAN (67-585): 3.79e-11: 69.3: 8.30
+	Hs
		1129830 H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62		TITIN_HUMAN (69-503): 2.16e-10: 67: 12.74
+	Hs
		617962 H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21		TITIN_HUMAN (69-503): 2.16e-10: 67: 12.74
+	Hs
		1087338 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		CHAP1_HUMAN (8-418): 1.11e-10: 67.5: 9.18
+	Hs
		918607 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		CHAP1_HUMAN (8-418): 1.11e-10: 67.5: 9.18
+	Hs
		1087299 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		TITIN_HUMAN (69-503): 2.16e-10: 67: 12.74
+	Hs
		1264778 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		TITIN_HUMAN (69-503): 2.16e-10: 67: 12.74
+	Hs
		883041 H2BFS_HUMAN (1-126): 1.26e-53: 166: 96.83		TITIN_HUMAN (69-503): 2.16e-10: 67: 12.74
+	Hs
		918561 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		TITIN_HUMAN (69-503): 2.16e-10: 67: 12.74
+	Hs
		1087220 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		TICRR_HUMAN (236-527): 4.04e-09: 62.7: 14.05
+	Hs
		1187998 H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03		TICRR_HUMAN (236-527): 4.04e-09: 62.7: 14.05
+	Hs
		152598 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		KMT2D_HUMAN (222-526): 5.34e-09: 62.7: 13.31