HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: SRCAP (Q6ZRS2)
Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)
Gene: SRCAP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 3230
+	Hs
		918462 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		SRCAP_HUMAN (1-3230): 0: 1210: 100.00
+	Hs
		1059648 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60
+	Hs
		1059777 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60
+	Hs
		918368 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		CHD4_HUMAN (1959-2633): 3.48e-89: 328: 19.60
+	Hs
		658646 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		SMCA1_HUMAN (2003-2406): 8.09e-92: 327: 26.49
+	Hs
		658684 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		SMCA1_HUMAN (2003-2406): 8.09e-92: 327: 26.49
+	Hs
		918541 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		CHD5_HUMAN (1995-2642): 4.91e-88: 324: 19.69
+	Hs
		229353 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77
+	Hs
		229415 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77
+	Hs
		229458 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77
+	Hs
		229321 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		SMCA5_HUMAN (2003-2357): 1.13e-90: 323: 28.77
+	Hs
		151482 H2BFS_HUMAN (1-126): 1.26e-53: 166: 96.83		CHD2_HUMAN (2039-2386): 6.82e-78: 291: 27.90
+	Hs
		1087418 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		CHD8_HUMAN (2021-2361): 3.76e-67: 256: 28.57
+	Hs
		1307128 H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03		CHD8_HUMAN (2021-2361): 3.76e-67: 256: 28.57
+	Hs
		918705 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		CHD8_HUMAN (2021-2361): 3.76e-67: 256: 28.57
+	Hs
		846915 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		SMCA4_HUMAN (1505-1858): 9.38e-13: 76.9: 13.22
+	Hs
		846990 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		SMCA4_HUMAN (1505-1858): 9.38e-13: 76.9: 13.22
+	Hs
		1087343 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		EP400_HUMAN (1085-1716): 1.74e-11: 73: 13.39
+	Hs
		918613 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		EP400_HUMAN (1085-1716): 1.74e-11: 73: 13.39
+	Hs
		846736 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		SMCA2_HUMAN (1477-1770): 8.82e-09: 63.8: 11.91