Protein: SMCR8
Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein)

Gene: SMCR8
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q8TEV9

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0004860 - protein kinase inhibitor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1353193

CI072
Guanine nucleotide exchange factor C9orf72

8

1

Small-scale

0.977

High

552654

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

3

1

High-throughput

0.667

High

635353

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

3

1

High-throughput

0.662

High

384705

CRYAB
Alpha-crystallin B chain

3

0

High-throughput

0.638

High

239154

ZNRD2
Protein ZNRD2

3

0

High-throughput

0.634

High

279192

ULK1
Serine/threonine-protein kinase ULK1

2

1

Small-scale

0.586

High

1351910

RBCC1
RB1-inducible coiled-coil protein 1

2

0

High-throughput

0.585

High

391380

FRIL
Ferritin light chain

2

0

High-throughput

0.576

High

1353224

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

1

High-throughput

0.536

High

901965

RAB9A
Ras-related protein Rab-9A

2

4

High-throughput

0.533

High

1353223

ALK
ALK tyrosine kinase receptor

2

3

High-throughput

0.533

High

1093014

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.513

High

1205766

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.513

High

1353200

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1353219

TBK1
Serine/threonine-protein kinase TBK1

1

1

Small-scale

0.501

High

1353221

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.494

High

170522

RAB7L
Ras-related protein Rab-7L1

1

5

Small-scale

0.479

High

541608

FGFR1
Fibroblast growth factor receptor 1

1

4

High-throughput

0.479

High

601385

RHOQ
Rho-related GTP-binding protein RhoQ

1

3

High-throughput

0.479

High

604120

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

630589

RAB3B
Ras-related protein Rab-3B

1

3

High-throughput

0.479

High

631368

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.479

High

910144

RND2
Rho-related GTP-binding protein RhoN

1

4

High-throughput

0.479

High

955978

RAB8A
Ras-related protein Rab-8A

1

2

Small-scale

0.479

High

962306

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

962792

RND3
Rho-related GTP-binding protein RhoE

1

4

High-throughput

0.479

High

1015626

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1087210

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

1151795

RHOH
Rho-related GTP-binding protein RhoH

1

3

High-throughput

0.479

High

1353187

RAB24
Ras-related protein Rab-24

1

4

Small-scale

0.479

High

1353190

RB39B
Ras-related protein Rab-39B

1

4

Small-scale

0.479

High

1353204

RHOJ
Rho-related GTP-binding protein RhoJ

1

3

High-throughput

0.479

High

1353225

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.479

High

271552

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.460

High

187539

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

218530

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

226147

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

348627

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

404262

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

605757

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.458

High

611249

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

613414

VINC
Vinculin

1

0

High-throughput

0.458

High

698936

CALX
Calnexin

1

0

High-throughput

0.458

High

715688

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

837742

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

894929

EMD
Emerin

1

0

High-throughput

0.458

High

951295

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

1004140

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1041193

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1107957

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

1156160

ZYX
Zyxin

1

0

High-throughput

0.458

High

1214532

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1233378

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1278044

MAVS
Mitochondrial antiviral-signaling protein

1

0

High-throughput

0.458

High

1289480

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1333915

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1353189

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1353194

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1353195

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1353197

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

1353201

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1353207

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1353211

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

1353212

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1353220

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1353222

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.458

High

1353228

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

1110514

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.445

High

1353206

WDR41
WD repeat-containing protein 41

1

1

Small-scale

0.445

High

189734

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

412310

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

464016

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

3

High-throughput

0.437

High

560464

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

562262

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.437

High

630903

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.437

High

648602

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.437

High

900946

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.437

High

901423

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.437

High

945054

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.437

High

976444

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.437

High

1031471

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1058546

CKAP4
Cytoskeleton-associated protein 4

1

1

High-throughput

0.437

High

1116371

RAB32
Ras-related protein Rab-32

1

5

Small-scale

0.437

High

1145033

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.437

High

1312199

MIRO2
Mitochondrial Rho GTPase 2

1

6

High-throughput

0.437

High

1322910

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1353192

DNJC1
DnaJ homolog subfamily C member 1

1

2

High-throughput

0.437

High

1353202

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.437

High

1353216

MTCH1
Mitochondrial carrier homolog 1

1

1

High-throughput

0.437

High

1353218

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.437

High

1353229

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.437

High

58885

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

0

High-throughput

0.426

High

848687

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.279

Low

1200367

KCP3
Keratinocyte-associated protein 3

1

0

High-throughput

0.279

Low

1295073

F90A1
Protein FAM90A1

1

0

High-throughput

0.279

Low

139938

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

166965

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.249

Low

278911

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.249

Low

291454

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

326592

MFN2
Mitofusin-2

1

0

High-throughput

0.249

Low

327374

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

418298

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

488828

FURIN
Furin

1

0

High-throughput

0.249

Low

642986

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

710734

EPHA8
Ephrin type-A receptor 8

1

0

High-throughput

0.249

Low

847619

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

880625

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

904031

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.249

Low

1027104

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1111621

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.249

Low

1125566

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.249

Low

1147646

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

1293087

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1331226

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low

1353185

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

1353186

GOGA1
Golgin subfamily A member 1

1

0

High-throughput

0.249

Low

1353188

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1353191

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.249

Low

1353196

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

1353198

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.249

Low

1353199

DERL1
Derlin-1

1

0

High-throughput

0.249

Low

1353203

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1353205

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1353208

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1353209

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.249

Low

1353210

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low

1353213

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

1353214

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.249

Low

1353215

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1353217

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

1353226

DJC16
DnaJ homolog subfamily C member 16

1

0

High-throughput

0.249

Low

1353227

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.249

Low

1313764

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025