HitPredict

Interactor 1: DIAP1 (Q24306)
Death-associated inhibitor of apoptosis 1 (EC 2.3.2.27) (Apoptosis 1 inhibitor) (E3 ubiquitin-protein ligase th) (Inhibitor of apoptosis 1) (Protein thread) (RING-type E3 ubiquitin transferase Diap1)
Gene: DIAP1

Interactor 2: Q86PE7 (Q86PE7)
SD10041p
Gene: IKKepsilon

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	16887178
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, protein kinase assay
Interaction Type	physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0045035 - sensory organ precursor cell division
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 438 Dm			1 720
+	Dm
		1097060 DIAP1_DROME (1-438): 9.76e-155: 447: 100.00		Q9V3Y8_DROME (1-720): 1.22e-171: 511: 99.86
+	Hs
		957793 XIAP_HUMAN (2-156): 4.71e-38: 146: 21.25		TBK1_HUMAN (4-715): 7.57e-131: 406: 36.28
+	Hs
		957702 XIAP_HUMAN (2-156): 4.71e-38: 146: 21.25		IKKE_HUMAN (4-704): 1.33e-128: 399: 36.30
+	Hs
		1036366 BIRC2_HUMAN (181-401): 6.9e-20: 94.3: 16.96		TBK1_HUMAN (4-715): 7.57e-131: 406: 36.28
+	Hs
		1035721 BIRC3_HUMAN (213-401): 2.67e-20: 95.4: 21.08		IKKE_HUMAN (4-704): 1.33e-128: 399: 36.30
+	Hs
		158466 BIRC3_HUMAN (213-401): 2.67e-20: 95.4: 21.08		IKKB_HUMAN (12-719): 1.27e-127: 398: 19.81
+	Hs
		1036267 BIRC2_HUMAN (181-401): 6.9e-20: 94.3: 16.96		IKKE_HUMAN (4-704): 1.33e-128: 399: 36.30
+	Mm
		1193400 MIB1_MOUSE (260-436): 8.28e-14: 75.8: 17.13		TBK1_MOUSE (4-663): 7.41e-131: 406: 38.17
+	Hs
		1206082 MIB1_HUMAN (260-436): 3.25e-13: 73.8: 17.13		TBK1_HUMAN (4-715): 7.57e-131: 406: 36.28
+	Hs
		1284698 MIB2_HUMAN (350-437): 1.79e-11: 68.5: 25.00		TBK1_HUMAN (4-715): 7.57e-131: 406: 36.28
+	Hs
		177650 BIRC5_HUMAN (36-114): 1.62e-27: 108: 25.88		CDK2_HUMAN (9-312): 2.74e-121: 366: 21.54
+	Hs
		625412 BIRC3_HUMAN (213-401): 2.67e-20: 95.4: 21.08		CDK2_HUMAN (9-312): 2.74e-121: 366: 21.54
+	Hs
		1035911 BIRC3_HUMAN (213-401): 2.67e-20: 95.4: 21.08		MK15_HUMAN (2-424): 3.56e-114: 356: 18.45
+	Hs
		167539 BIRC3_HUMAN (213-401): 2.67e-20: 95.4: 21.08		IKKA_HUMAN (4-657): 9.55e-112: 356: 20.72
+	Hs
		154168 XIAP_HUMAN (2-156): 4.71e-38: 146: 21.25		CHK1_HUMAN (12-224): 2.33e-20: 96.7: 32.72
+	Hs
		883164 LRSM1_HUMAN (293-438): 5.05e-24: 106: 20.27		HUNK_HUMAN (18-249): 1.4e-20: 98.6: 31.84
+	Hs
		154098 MDM4_HUMAN (257-438): 1.06e-23: 105: 14.65		CHK1_HUMAN (12-224): 2.33e-20: 96.7: 32.72
+	Hs
		262265 BIRC2_HUMAN (181-401): 6.9e-20: 94.3: 16.96		ULK1_HUMAN (17-225): 2.35e-20: 98.6: 31.48