Protein: PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)

Gene: PRDX3
Organism: Homo sapiens
Interactions: 236
UniProt ID: P30048

Gene Ontology (top 5):
GO:0001893 - maternal placenta development
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

716492

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

3

14

Small-scale

0.820

High

716539

PRDX1
Peroxiredoxin-1

2

15

High-throughput

0.776

High

716496

PRDX2
Peroxiredoxin-2

1

15

High-throughput

0.691

High

245429

OPA1
Dynamin-like GTPase OPA1, mitochondrial

4

4

High-throughput

0.691

High

716567

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

4

8

Small-scale

0.685

High

716551

CUL4B
Cullin-4B

3

18

Small-scale

0.674

High

716547

BIRC2
Baculoviral IAP repeat-containing protein 2

3

10

High-throughput

0.667

High

716615

DHRS4
Dehydrogenase/reductase SDR family member 4

3

1

High-throughput

0.667

High

212010

M3K13
Mitogen-activated protein kinase kinase kinase 13

2

4

Small-scale

0.644

High

716545

PRDX4
Peroxiredoxin-4

1

15

High-throughput

0.621

High

716524

CDC42
Cell division control protein 42 homolog

2

7

High-throughput

0.619

High

716533

XIAP
E3 ubiquitin-protein ligase XIAP

2

10

High-throughput

0.611

High

716550

CUL3
Cullin-3

2

18

High-throughput

0.611

High

716629

GORS2
Golgi reassembly-stacking protein 2

3

1

High-throughput

0.606

High

619531

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.601

High

371260

MYC
Myc proto-oncogene protein

2

9

High-throughput

0.584

High

400345

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

6

High-throughput

0.584

High

716504

MDHM
Malate dehydrogenase, mitochondrial

2

7

High-throughput

0.584

High

716505

CCNF
Cyclin-F

2

6

High-throughput

0.584

High

716518

TERA
Transitional endoplasmic reticulum ATPase

2

8

High-throughput

0.571

High

716564

RHG31
Rho GTPase-activating protein 31

2

5

High-throughput

0.571

High

716582

RHG24
Rho GTPase-activating protein 24

2

5

High-throughput

0.571

High

716562

ZNF77
Zinc finger protein 77

2

1

High-throughput

0.553

High

566569

PDIA4
Protein disulfide-isomerase A4

1

14

High-throughput

0.553

High

563264

CFTR
Cystic fibrosis transmembrane conductance regulator

2

4

High-throughput

0.552

High

716586

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.547

High

716507

MAGAB
Melanoma-associated antigen 11

1

4

High-throughput

0.541

High

213827

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.536

High

389071

FINC
Fibronectin

1

4

High-throughput

0.536

High

484394

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

8

High-throughput

0.536

High

550867

PCNA
Proliferating cell nuclear antigen

1

3

High-throughput

0.536

High

573757

CCNB1
G2/mitotic-specific cyclin-B1

1

2

High-throughput

0.536

High

591496

H2AX
Histone H2AX

1

4

High-throughput

0.536

High

623996

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

4

High-throughput

0.536

High

640775

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

1

High-throughput

0.536

High

716494

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.536

High

716497

CNR2
Cannabinoid receptor 2

1

1

Small-scale

0.536

High

716503

SYUA
Alpha-synuclein

1

3

High-throughput

0.536

High

716510

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

7

High-throughput

0.536

High

716514

ANX11
Annexin A11

1

4

High-throughput

0.536

High

716538

KPCZ
Protein kinase C zeta type

1

4

High-throughput

0.536

High

716548

CUL1
Cullin-1

1

18

High-throughput

0.536

High

716549

CUL2
Cullin-2

1

18

High-throughput

0.536

High

716556

PLSI
Plastin-1

1

3

High-throughput

0.536

High

716576

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.536

High

716577

COX15
Heme A synthase COX15

1

3

High-throughput

0.536

High

716579

NLRX1
NLR family member X1

1

6

High-throughput

0.536

High

716596

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

716597

CUL5
Cullin-5

1

18

High-throughput

0.536

High

716604

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.536

High

716606

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

716609

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.536

High

716610

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.536

High

716611

PARK7
Parkinson disease protein 7

1

4

High-throughput

0.536

High

716612

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

7

High-throughput

0.536

High

716621

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

4

High-throughput

0.536

High

716633

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

3

High-throughput

0.536

High

716634

PAR6A
Partitioning defective 6 homolog alpha

1

5

High-throughput

0.536

High

105413

APRIO
Alternative prion protein

2

3

High-throughput

0.533

High

185165

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.529

High

716632

NEK6
Serine/threonine-protein kinase Nek6

1

7

Small-scale

0.527

High

622530

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

0

High-throughput

0.518

High

167829

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

5

Small-scale

0.515

High

273401

KDM4A
Lysine-specific demethylase 4A

1

0

High-throughput

0.513

High

716502

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

716531

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.513

High

716635

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.513

High

716522

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

High-throughput

0.501

High

339665

KLF8
Krueppel-like factor 8

1

2

High-throughput

0.500

High

256584

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

1

High-throughput

0.489

High

716501

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.489

High

403850

GCR
Glucocorticoid receptor

1

16

Small-scale

0.481

High

716553

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

High-throughput

0.481

High

716608

KS6C1
Ribosomal protein S6 kinase delta-1

1

2

High-throughput

0.481

High

125257

LEG9
Galectin-9

1

6

High-throughput

0.479

High

131753

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

High-throughput

0.479

High

156989

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

158122

COPE
Coatomer subunit epsilon

1

2

High-throughput

0.479

High

174222

ARHGA
Rho guanine nucleotide exchange factor 10

1

7

High-throughput

0.479

High

217872

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

227392

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

240843

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

271926

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

279663

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

281892

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

293258

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

315169

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

319436

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.479

High

320630

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.479

High

324282

ARHGF
Rho guanine nucleotide exchange factor 15

1

3

High-throughput

0.479

High

324573

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

335010

ARI2
E3 ubiquitin-protein ligase ARIH2

1

8

High-throughput

0.479

High

375215

RASK
GTPase KRas

1

4

High-throughput

0.479

High

405822

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

413260

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

470866

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

486994

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

507569

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

532385

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

565172

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

587991

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

599160

IL7RA
Interleukin-7 receptor subunit alpha

1

2

High-throughput

0.479

High

615486

NELFE
Negative elongation factor E

1

1

High-throughput

0.479

High

616138

PGAM1
Phosphoglycerate mutase 1

1

4

High-throughput

0.479

High

623127

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.479

High

656045

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

7

High-throughput

0.479

High

667562

CDK2
Cyclin-dependent kinase 2

1

9

High-throughput

0.479

High

687137

HMGB2
High mobility group protein B2

1

9

High-throughput

0.479

High

691640

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.479

High

694701

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

697775

CALR
Calreticulin

1

6

High-throughput

0.479

High

716493

PEBP1
Phosphatidylethanolamine-binding protein 1

1

4

High-throughput

0.479

High

716495

1433B
14-3-3 protein beta/alpha

1

7

High-throughput

0.479

High

716499

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

716500

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

716509

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

716511

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

716512

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

716513

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

716515

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.479

High

716516

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.479

High

716517

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

716521

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

6

High-throughput

0.479

High

716525

UBC12
NEDD8-conjugating enzyme Ubc12

1

5

High-throughput

0.479

High

716526

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.479

High

716527

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

716529

RL11
Large ribosomal subunit protein uL5

1

1

Small-scale

0.479

High

716532

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

716540

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

High-throughput

0.479

High

716541

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

716542

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

716543

TP4A2
Protein tyrosine phosphatase type IVA 2

1

9

High-throughput

0.479

High

716544

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

2

High-throughput

0.479

High

716546

BIRC3
Baculoviral IAP repeat-containing protein 3

1

10

High-throughput

0.479

High

716552

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

4

High-throughput

0.479

High

716554

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

716555

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

716557

CUL7
Cullin-7

1

4

High-throughput

0.479

High

716558

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

716559

ARHG6
Rho guanine nucleotide exchange factor 6

1

2

High-throughput

0.479

High

716561

TERF2
Telomeric repeat-binding factor 2

1

4

High-throughput

0.479

High

716565

SMU1
WD40 repeat-containing protein SMU1

1

6

High-throughput

0.479

High

716566

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

716570

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

716571

PRP8
Pre-mRNA-processing-splicing factor 8

1

4

High-throughput

0.479

High

716574

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

716575

ASXL2
Putative Polycomb group protein ASXL2

1

10

High-throughput

0.479

High

716578

ZFY16
Zinc finger FYVE domain-containing protein 16

1

5

Small-scale

0.479

High

716580

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.479

High

716581

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

716584

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.479

High

716585

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

716587

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

716591

TOPB1
DNA topoisomerase 2-binding protein 1

1

7

High-throughput

0.479

High

716592

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

716593

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

2

High-throughput

0.479

High

716598

FBXW7
F-box/WD repeat-containing protein 7

1

8

High-throughput

0.479

High

716601

CHM4C
Charged multivesicular body protein 4c

1

6

High-throughput

0.479

High

716602

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

716603

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

Small-scale

0.479

High

716605

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

716607

EFGM
Elongation factor G, mitochondrial

1

7

High-throughput

0.479

High

716613

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

716614

RHG09
Rho GTPase-activating protein 9

1

9

High-throughput

0.479

High

716619

RHG39
Rho GTPase-activating protein 39

1

6

High-throughput

0.479

High

716626

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

716627

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

716631

CYBP
Calcyclin-binding protein

1

3

High-throughput

0.479

High

716636

PIHD1
PIH1 domain-containing protein 1

1

4

High-throughput

0.479

High

716638

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.479

High

716640

RHG23
Rho GTPase-activating protein 23

1

7

High-throughput

0.479

High

716641

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

716642

DS13B
Dual specificity protein phosphatase 13B

1

3

High-throughput

0.479

High

716644

HDAC5
Histone deacetylase 5

1

8

High-throughput

0.479

High

716647

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

716648

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

11

Small-scale

0.479

High

716535

FANCC
Fanconi anemia group C protein

1

0

Small-scale

0.460

High

61435

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

128796

MEN1
Menin

1

0

High-throughput

0.458

High

459473

PROF1
Profilin-1

1

0

High-throughput

0.458

High

599544

STMN1
Stathmin

1

0

High-throughput

0.458

High

635780

PTMS
Parathymosin

1

0

High-throughput

0.458

High

716508

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

716519

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

716528

H4
Histone H4

1

0

High-throughput

0.458

High

716530

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.458

High

716536

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

716560

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

716563

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

716569

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

716583

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

716589

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

716599

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

716600

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

716616

TR61B
tRNA

1

0

High-throughput

0.458

High

716618

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

716628

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

716637

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

716639

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

716643

PALD
Paladin

1

0

High-throughput

0.458

High

716588

MUC7
Mucin-7

1

1

Small-scale

0.457

High

716617

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.457

High

135513

DNM1L
Dynamin-1-like protein

1

3

Small-scale

0.445

High

244931

KATIP
Katanin-interacting protein

1

1

High-throughput

0.445

High

327816

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

342758

HERC2
E3 ubiquitin-protein ligase HERC2

1

7

High-throughput

0.445

High

395558

ESR1
Estrogen receptor

1

16

High-throughput

0.445

High

404692

PRIO
Major prion protein

1

1

High-throughput

0.445

High

429366

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

529163

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

583470

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

5

High-throughput

0.445

High

716498

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.445

High

716506

S19A1
Reduced folate transporter

1

2

High-throughput

0.445

High

716520

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.445

High

716523

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

716534

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.445

High

716568

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.445

High

716572

ZNT10
Calcium/manganese antiporter SLC30A10

1

1

High-throughput

0.445

High

716573

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

2

High-throughput

0.445

High

716594

ESR2
Estrogen receptor beta

1

16

High-throughput

0.445

High

716620

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

20

High-throughput

0.445

High

716622

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

716624

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

20

High-throughput

0.445

High

716646

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

4

High-throughput

0.445

High

716649

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

353013

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.437

High

698412

CALX
Calnexin

1

6

High-throughput

0.437

High

716590

STAR8
StAR-related lipid transfer protein 8

1

5

High-throughput

0.437

High

716625

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.437

High

716630

WDR76
WD repeat-containing protein 76

1

9

High-throughput

0.437

High

716645

AAR2
Protein AAR2 homolog

1

4

High-throughput

0.437

High

716537

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

345154

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

716623

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

716595

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025