HitPredict

Interactor 1: CUL1 (Q24311)
Cullin homolog 1 (Lin-19 homolog protein)
Gene: CUL1

Interactor 2: NEDD8 (Q9VJ33)
NEDD8 (Neddylin) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	12231629, 12737805, 18782863
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~ubiquitin, Cullin_Nedd8~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0031625 - ubiquitin protein ligase binding GO:0045879 - negative regulation of smoothened signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 774 Dm			1 84
+	Hs
		1041004 CUL1_HUMAN (3-774): 0: 825: 61.68		NEDD8_HUMAN (1-76): 1.22e-39: 127: 93.42
+	Hs
		1043010 CUL4A_HUMAN (17-774): 0: 774: 29.84		NEDD8_HUMAN (1-76): 1.22e-39: 127: 93.42
+	Hs
		1041658 CUL3_HUMAN (3-774): 0: 771: 27.45		NEDD8_HUMAN (1-76): 1.22e-39: 127: 93.42
+	Hs
		923984 CUL4A_HUMAN (17-774): 0: 774: 29.84		RS27A_HUMAN (1-77): 1.02e-37: 124: 57.14
+	Hs
		923983 CUL3_HUMAN (3-774): 0: 771: 27.45		RS27A_HUMAN (1-77): 1.02e-37: 124: 57.14
+	Hs
		924296 CUL4A_HUMAN (17-774): 0: 774: 29.84		RL40_HUMAN (1-81): 8.37e-36: 119: 54.32
+	Hs
		1043371 CUL4B_HUMAN (3-774): 0: 756: 29.18		NEDD8_HUMAN (1-76): 1.22e-39: 127: 93.42
+	At
		1352191 CUL3A_ARATH (3-774): 0: 780: 28.84		RUB1_ARATH (2-76): 4.04e-28: 100: 84.00
+	Hs
		923985 CUL4B_HUMAN (3-774): 0: 756: 29.18		RS27A_HUMAN (1-77): 1.02e-37: 124: 57.14
+	Sp
		142907 CUL1_SCHPO (11-774): 0: 754: 39.66		UBL1_SCHPO (1-76): 4.36e-36: 118: 81.58
+	At
		1321116 CUL3B_ARATH (3-774): 0: 770: 28.21		RUB1_ARATH (2-76): 4.04e-28: 100: 84.00
+	Hs
		475024 CUL4B_HUMAN (3-774): 0: 756: 29.18		UBB_HUMAN (1-76): 2.22e-32: 113: 57.90
+	Hs
		1041337 CUL2_HUMAN (7-774): 0: 734: 33.04		NEDD8_HUMAN (1-76): 1.22e-39: 127: 93.42
+	Dm
		1213846 Q8IP45_DROME (3-774): 0: 749: 27.50		NEDD8_DROME (1-84): 1.87e-32: 109: 100.00
+	At
		1091919 CUL1_ARATH (9-774): 0: 734: 27.86		UBQ3_ARATH (1-77): 2.02e-29: 107: 58.44
+	At
		1277343 CUL1_ARATH (9-774): 0: 734: 27.86		RUB1_ARATH (2-76): 4.04e-28: 100: 84.00
+	At
		1247030 CUL1_ARATH (9-774): 0: 734: 27.86		RUB2_ARATH (2-76): 6.08e-27: 97.5: 84.00
+	Ce
		1088883 CUL3_CAEEL (3-774): 0: 693: 24.63		NEDD8_CAEEL (1-77): 2.45e-35: 116: 88.31
+	Hs
		1079566 CUL5_HUMAN (11-774): 0: 634: 26.34		NEDD8_HUMAN (1-76): 1.22e-39: 127: 93.42
+	Sp
		145590 CUL3_SCHPO (12-774): 0: 633: 25.71		UBL1_SCHPO (1-76): 4.36e-36: 118: 81.58