HitPredict

Interactor 1: PCL (Q24459)
Polycomb protein Pcl (Polycomblike protein)
Gene: PCL

Interactor 2: HDAC1 (Q94517)
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)
Gene: HDAC1

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	12697833
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005700 - polytene chromosome GO:0005737 - cytoplasm GO:0006325 - chromatin organization GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1043 Dm			1 521
+	Hs
		1270542 MTF2_HUMAN (344-824): 8.83e-112: 360: 25.45		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		1038718 CSR2B_HUMAN (518-906): 4.72e-116: 377: 21.21		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		198026 PHF1_HUMAN (323-742): 3.26e-88: 296: 27.42		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		197980 PHF1_HUMAN (323-742): 3.26e-88: 296: 27.42		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		975297 KMT2A_HUMAN (184-601): 1.2e-34: 146: 12.04		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		1059770 CHD4_HUMAN (409-579): 2.55e-34: 145: 18.08		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Mm
		936393 Q5DTP7_MOUSE (409-579): 4.56e-34: 144: 17.05		HDAC2_MOUSE (2-488): 0: 655: 76.18
+	Hs
		1038822 KMT2B_HUMAN (269-600): 8.48e-38: 156: 14.45		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1255037 CHD5_HUMAN (414-578): 5.28e-31: 134: 15.98		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Mm
		56900 CHD5_MOUSE (316-578): 1.15e-31: 136: 11.51		HDAC2_MOUSE (2-488): 0: 655: 76.18
+	Mm
		140286 CHD4_MOUSE (409-579): 4.05e-34: 144: 17.05		HDAC1_MOUSE (3-443): 0: 640: 81.18
+	Hs
		975244 KMT2A_HUMAN (184-601): 1.2e-34: 146: 12.04		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1038382 CHD4_HUMAN (409-579): 2.55e-34: 145: 18.08		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Mm
		56897 CHD5_MOUSE (316-578): 1.15e-31: 136: 11.51		HDAC1_MOUSE (3-443): 0: 640: 81.18
+	Hs
		1038563 CHD5_HUMAN (414-578): 5.28e-31: 134: 15.98		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Ce
		104624 LE418_CAEEL (333-580): 3.9e-30: 131: 16.99		HDA1_CAEEL (1-456): 0: 593: 64.05
+	Hs
		152639 KMT2D_HUMAN (2-408): 2.68e-09: 63.9: 11.33		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1056969 MDC1_HUMAN (24-346): 5.69e-09: 62.6: 19.95		HDAC8_HUMAN (30-369): 4.56e-139: 407: 42.82