Protein: S1PR3
Sphingosine 1-phosphate receptor 3 (S1P receptor 3) (S1P3) (Endothelial differentiation G-protein coupled receptor 3) (Sphingosine 1-phosphate receptor Edg-3) (S1P receptor Edg-3)

Gene: S1PR3
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q99500

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005178 - integrin binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

477144

5HT1A
5-hydroxytryptamine receptor 1A

1

19

Small-scale

0.618

High

642278

COMT
Catechol O-methyltransferase

2

3

High-throughput

0.606

High

438099

GLPB
Glycophorin-B

2

0

High-throughput

0.580

High

1253790

QSOX2
Sulfhydryl oxidase 2

1

4

High-throughput

0.575

High

1404958

SLAF7
SLAM family member 7

1

3

High-throughput

0.575

High

1394647

TXD15
Thioredoxin domain-containing protein 15

1

4

High-throughput

0.514

High

1404976

DJC16
DnaJ homolog subfamily C member 16

1

6

High-throughput

0.514

High

592688

ITB4
Integrin beta-4

1

6

Small-scale

0.479

High

125779

STXB3
Syntaxin-binding protein 3

1

3

High-throughput

0.445

High

133568

ACATN
Acetyl-coenzyme A transporter 1

1

2

High-throughput

0.445

High

178370

NPC1
NPC intracellular cholesterol transporter 1

1

10

High-throughput

0.445

High

190634

MRP4
ATP-binding cassette sub-family C member 4

1

7

High-throughput

0.445

High

208554

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

High-throughput

0.445

High

256119

S19A2
Thiamine transporter 1

1

3

High-throughput

0.445

High

270677

ATP9A
Probable phospholipid-transporting ATPase IIA

1

5

High-throughput

0.445

High

326976

UBE4B
Ubiquitin conjugation factor E4 B

1

1

High-throughput

0.445

High

344424

TBCD8
TBC1 domain family member 8

1

3

High-throughput

0.445

High

443936

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

6

High-throughput

0.445

High

519655

LYAG
Lysosomal alpha-glucosidase

1

1

High-throughput

0.445

High

624664

SL9A1
Sodium/hydrogen exchanger 1

1

4

High-throughput

0.445

High

720023

HMOX2
Heme oxygenase 2

1

3

High-throughput

0.445

High

722589

CTR1
High affinity cationic amino acid transporter 1

1

5

High-throughput

0.445

High

753840

MRP1
Multidrug resistance-associated protein 1

1

7

High-throughput

0.445

High

878081

AGRE5
Adhesion G protein-coupled receptor E5

1

11

High-throughput

0.445

High

908312

ADCY7
Adenylate cyclase type 7

1

2

High-throughput

0.445

High

945522

GSDMD
Gasdermin-D

1

1

High-throughput

0.445

High

1023384

AT2C1
Calcium-transporting ATPase type 2C member 1

1

20

High-throughput

0.445

High

1087254

STX4
Syntaxin-4

1

2

High-throughput

0.445

High

1093567

TRDN
Triadin

1

4

High-throughput

0.445

High

1105237

S39A6
Zinc transporter ZIP6

1

20

High-throughput

0.445

High

1106810

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

1

High-throughput

0.445

High

1127635

SCN5A
Sodium channel protein type 5 subunit alpha

1

2

High-throughput

0.445

High

1128364

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

3

High-throughput

0.445

High

1128460

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

3

High-throughput

0.445

High

1139812

SETB1
Histone-lysine N-methyltransferase SETDB1

1

1

High-throughput

0.445

High

1154070

MSMO1
Methylsterol monooxygenase 1

1

7

High-throughput

0.445

High

1195378

ANO6
Anoctamin-6

1

4

High-throughput

0.445

High

1228846

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

5

High-throughput

0.445

High

1241645

ANM9
Protein arginine N-methyltransferase 9

1

1

High-throughput

0.445

High

1272092

MIGA2
Mitoguardin 2

1

2

High-throughput

0.445

High

1273966

DYM
Dymeclin

1

4

High-throughput

0.445

High

1279223

WAPL
Wings apart-like protein homolog

1

1

High-throughput

0.445

High

1280073

FRMD5
FERM domain-containing protein 5

1

6

High-throughput

0.445

High

1290218

GP180
Integral membrane protein GPR180

1

5

High-throughput

0.445

High

1309799

IPRI
Inositol 1,4,5-trisphosphate receptor-interacting protein

1

4

High-throughput

0.445

High

1310838

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

5

High-throughput

0.445

High

1311091

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.445

High

1333765

TM87A
Transmembrane protein 87A

1

5

High-throughput

0.445

High

1335567

DGLB
Diacylglycerol lipase-beta

1

3

High-throughput

0.445

High

1337925

ZNT7
Zinc transporter 7

1

14

High-throughput

0.445

High

1339280

RAI3
Retinoic acid-induced protein 3

1

12

High-throughput

0.445

High

1340233

MSPD2
Motile sperm domain-containing protein 2

1

1

High-throughput

0.445

High

1348183

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.445

High

1349315

TBC15
TBC1 domain family member 15

1

9

High-throughput

0.445

High

1388840

HOOK2
Protein Hook homolog 2

1

1

High-throughput

0.445

High

1401209

PANX1
Pannexin-1

1

1

High-throughput

0.445

High

1401679

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

9

High-throughput

0.445

High

1404937

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

5

High-throughput

0.445

High

1404941

ZDHC5
Palmitoyltransferase ZDHHC5

1

11

High-throughput

0.445

High

1404942

XPO4
Exportin-4

1

11

High-throughput

0.445

High

1404944

GOLP3
Golgi phosphoprotein 3

1

6

High-throughput

0.445

High

1404950

CNNM2
Metal transporter CNNM2

1

5

High-throughput

0.445

High

1404954

TRPV4
Transient receptor potential cation channel subfamily V member 4

1

2

High-throughput

0.445

High

1404956

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

4

High-throughput

0.445

High

1404959

GPC5C
G-protein coupled receptor family C group 5 member C

1

12

High-throughput

0.445

High

1404962

LRC4B
Leucine-rich repeat-containing protein 4B

1

1

High-throughput

0.445

High

1404966

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

3

High-throughput

0.445

High

1404968

ATX10
Ataxin-10

1

1

High-throughput

0.445

High

1404969

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.445

High

1404971

LCAP
Leucyl-cystinyl aminopeptidase

1

3

High-throughput

0.445

High

1404972

S39AA
Zinc transporter ZIP10

1

20

High-throughput

0.445

High

1404975

NAC2
Sodium/calcium exchanger 2

1

3

High-throughput

0.445

High

1404980

TNPO3
Transportin-3

1

18

High-throughput

0.445

High

1404981

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

13

High-throughput

0.445

High

133786

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.426

High

212884

AP5Z1
AP-5 complex subunit zeta-1

1

0

High-throughput

0.426

High

608338

EGLN
Endoglin

1

0

High-throughput

0.426

High

828436

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.426

High

1022944

EFNB1
Ephrin-B1

1

0

High-throughput

0.426

High

1175834

T132A
Transmembrane protein 132A

1

0

High-throughput

0.426

High

1201877

PKHG4
Puratrophin-1

1

0

High-throughput

0.426

High

1233436

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.426

High

1275958

SETX
Probable helicase senataxin

1

0

High-throughput

0.426

High

1363517

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

0

High-throughput

0.426

High

1393571

INT4
Integrator complex subunit 4

1

0

High-throughput

0.426

High

1395017

SPTCS
Spatacsin

1

0

High-throughput

0.426

High

1403688

NIBA2
Protein Niban 2

1

0

High-throughput

0.426

High

1404953

RRAGC
Ras-related GTP-binding protein C

1

0

High-throughput

0.426

High

1404955

EPG5
Ectopic P granules protein 5 homolog

1

0

High-throughput

0.426

High

1404964

EXOC1
Exocyst complex component 1

1

0

High-throughput

0.426

High

1404970

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.426

High

1404982

S23IP
SEC23-interacting protein

1

0

High-throughput

0.426

High

173743

BTAF1
TATA-binding protein-associated factor 172

1

6

High-throughput

0.407

High

185030

SPTC2
Serine palmitoyltransferase 2

1

4

High-throughput

0.407

High

189260

IPO8
Importin-8

1

12

High-throughput

0.407

High

193718

TPSN
Tapasin

1

2

High-throughput

0.407

High

219356

B4GA1
Beta-1,4-glucuronyltransferase 1

1

3

High-throughput

0.407

High

226448

SNG2
Synaptogyrin-2

1

5

High-throughput

0.407

High

270046

XYLK
Glycosaminoglycan xylosylkinase

1

2

High-throughput

0.407

High

301651

WFS1
Wolframin

1

2

High-throughput

0.407

High

316555

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

4

High-throughput

0.407

High

334885

IPO7
Importin-7

1

13

High-throughput

0.407

High

357973

CYB5
Cytochrome b5

1

4

High-throughput

0.407

High

399733

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

10

High-throughput

0.407

High

506649

GPHRB
Golgi pH regulator B

1

7

High-throughput

0.407

High

536286

PPAL
Lysosomal acid phosphatase

1

5

High-throughput

0.407

High

560064

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.407

High

687125

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

2

High-throughput

0.407

High

773965

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.407

High

1006220

CNTP1
Contactin-associated protein 1

1

8

High-throughput

0.407

High

1053829

KDSR
3-ketodihydrosphingosine reductase

1

13

High-throughput

0.407

High

1085272

NU160
Nuclear pore complex protein Nup160

1

1

High-throughput

0.407

High

1085370

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

11

High-throughput

0.407

High

1097875

STX5
Syntaxin-5

1

4

High-throughput

0.407

High

1197269

MBRL
Membralin

1

5

High-throughput

0.407

High

1198273

FND3B
Fibronectin type III domain-containing protein 3B

1

6

High-throughput

0.407

High

1203386

YIF1B
Protein YIF1B

1

3

High-throughput

0.407

High

1204589

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

8

High-throughput

0.407

High

1226418

TBC9B
TBC1 domain family member 9B

1

3

High-throughput

0.407

High

1238584

RINT1
RAD50-interacting protein 1

1

3

High-throughput

0.407

High

1245991

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

14

High-throughput

0.407

High

1248649

LCLT1
Lysocardiolipin acyltransferase 1

1

5

High-throughput

0.407

High

1251553

THADA
tRNA

1

5

High-throughput

0.407

High

1254034

NBEL1
Neurobeachin-like protein 1

1

4

High-throughput

0.407

High

1275400

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

5

High-throughput

0.407

High

1278668

CF120
UPF0669 protein C6orf120

1

1

High-throughput

0.407

High

1287770

NOP9
Nucleolar protein 9

1

4

High-throughput

0.407

High

1307552

ZDH13
Palmitoyltransferase ZDHHC13

1

6

High-throughput

0.407

High

1312973

S35F2
Solute carrier family 35 member F2

1

3

High-throughput

0.407

High

1315476

K2013
Uncharacterized protein KIAA2013

1

6

High-throughput

0.407

High

1327499

CERS5
Ceramide synthase 5

1

13

High-throughput

0.407

High

1329302

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

1

High-throughput

0.407

High

1348303

GOGA5
Golgin subfamily A member 5

1

5

High-throughput

0.407

High

1352928

PO210
Nuclear pore membrane glycoprotein 210

1

1

High-throughput

0.407

High

1353081

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

8

High-throughput

0.407

High

1357365

NAT14
Probable N-acetyltransferase 14

1

1

High-throughput

0.407

High

1362077

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

2

High-throughput

0.407

High

1383447

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

4

High-throughput

0.407

High

1385193

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.407

High

1389566

SAAL1
Protein SAAL1

1

3

High-throughput

0.407

High

1402369

CLCC1
Chloride channel CLIC-like protein 1

1

1

High-throughput

0.407

High

1404938

PTSS2
Phosphatidylserine synthase 2

1

6

High-throughput

0.407

High

1404939

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.407

High

1404940

FUT8
Alpha-(1,6)-fucosyltransferase

1

3

High-throughput

0.407

High

1404943

LNP
Endoplasmic reticulum junction formation protein lunapark

1

2

High-throughput

0.407

High

1404946

SG196
Protein O-mannose kinase

1

2

High-throughput

0.407

High

1404947

AT133
Polyamine-transporting ATPase 13A3

1

20

High-throughput

0.407

High

1404948

PGES2
Prostaglandin E synthase 2

1

1

High-throughput

0.407

High

1404949

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

4

High-throughput

0.407

High

1404951

GORS2
Golgi reassembly-stacking protein 2

1

1

High-throughput

0.407

High

1404952

TBC17
TBC1 domain family member 17

1

9

High-throughput

0.407

High

1404957

AT131
Endoplasmic reticulum transmembrane helix translocase

1

20

High-throughput

0.407

High

1404960

VPS45
Vacuolar protein sorting-associated protein 45

1

3

High-throughput

0.407

High

1404961

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

3

High-throughput

0.407

High

1404963

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

3

High-throughput

0.407

High

1404965

RMND1
Required for meiotic nuclear division protein 1 homolog

1

3

High-throughput

0.407

High

1404973

TPC1
Two pore channel protein 1

1

6

High-throughput

0.407

High

1404974

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

2

High-throughput

0.407

High

1404977

MAN1
Inner nuclear membrane protein Man1

1

3

High-throughput

0.407

High

1404978

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

5

High-throughput

0.407

High

1404979

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

1

High-throughput

0.407

High

244396

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.232

Low

596702

NCPR
NADPH--cytochrome P450 reductase

1

0

High-throughput

0.232

Low

1108807

ASAH1
Acid ceramidase

1

0

High-throughput

0.232

Low

1162151

MA2A1
Alpha-mannosidase 2

1

0

High-throughput

0.232

Low

1194012

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

0

High-throughput

0.232

Low

1219954

FHI2A
FHF complex subunit HOOK interacting protein 2A

1

0

High-throughput

0.232

Low

1233782

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.232

Low

1278627

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.232

Low

1279121

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.232

Low

1287726

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.232

Low

1293551

HTR5A
HEAT repeat-containing protein 5A

1

0

High-throughput

0.232

Low

1293739

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.232

Low

1325274

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.232

Low

1356928

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.232

Low

1385746

INT12
Integrator complex subunit 12

1

0

High-throughput

0.232

Low

1404945

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.232

Low

1404967

STX18
Syntaxin-18

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025