HitPredict

Interactor 1: PSMD2 (Q13200)
26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Protein 55.11) (Tumor necrosis factor type 1 receptor-associated protein 2)
Gene: PSMD2

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.929

The method score is based on:

Property	Details
Experiments	35271311, 28292943, 33961781, 37354974, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	PC_rep~PC_rep, PC_rep~RPN2_N, PC_rep~RPN1_RPN2_N, RPN1_RPN2_N~RPN2_C
Common GO terms	GO:0000502 - proteasome complex GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 8 others more... GO:0005838 - proteasome regulatory particle GO:0008540 - proteasome regulatory particle, base subcomplex GO:0016020 - membrane GO:0022624 - proteasome accessory complex GO:0030234 - enzyme regulator activity GO:0034515 - proteasome storage granule GO:0042176 - regulation of protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1	908
Hs

1	953

Service provided by Combinatics, Japan

Last updated: 11Aug2025