Protein: RPN2
26S proteasome regulatory subunit RPN2

Gene: RPN2
Organism: Saccharomyces cerevisiae S288C
Interactions: 202
UniProt ID: P32565

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008540 - proteasome regulatory particle, base subcomplex
GO:0030234 - enzyme regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

740183

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

24

15

Small-scale

0.989

High

740157

RPN1
26S proteasome regulatory subunit RPN1

13

10

Small-scale

0.980

High

740232

RPN8
26S proteasome regulatory subunit RPN8

6

16

High-throughput

0.943

High

740168

RPN3
26S proteasome regulatory subunit RPN3

5

8

Small-scale

0.912

High

740125

RAD23
UV excision repair protein RAD23

4

20

Small-scale

0.881

High

740130

PRS7
26S proteasome regulatory subunit 7 homolog

12

20

Small-scale

0.756

High

364417

CDK1
Cyclin-dependent kinase 1

2

6

High-throughput

0.754

High

740123

RPN2
26S proteasome regulatory subunit RPN2

2

10

High-throughput

0.754

High

150275

RPN13
26S proteasome regulatory subunit RPN13

8

1

Small-scale

0.751

High

740129

PRS6B
26S proteasome regulatory subunit 6B homolog

9

20

Small-scale

0.749

High

740209

PRS8
26S proteasome regulatory subunit 8 homolog

9

20

Small-scale

0.746

High

740236

RPN5
26S proteasome regulatory subunit RPN5

7

16

Small-scale

0.746

High

740159

RPN10
26S proteasome regulatory subunit RPN10

6

7

Small-scale

0.734

High

738286

RPN12
26S proteasome regulatory subunit RPN12

6

7

Small-scale

0.729

High

740190

PSD10
Probable 26S proteasome regulatory subunit p28

5

5

Small-scale

0.716

High

740226

RPN7
26S proteasome regulatory subunit RPN7

5

17

High-throughput

0.716

High

740184

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

5

8

High-throughput

0.714

High

740222

RPN9
26S proteasome regulatory subunit RPN9

5

10

Small-scale

0.712

High

740238

RPN6
26S proteasome regulatory subunit RPN6

5

14

Small-scale

0.709

High

314854

SEM1
26S proteasome complex subunit SEM1

5

1

Small-scale

0.706

High

740172

PRS4
26S proteasome regulatory subunit 4 homolog

5

20

Small-scale

0.706

High

486433

TBA3
Tubulin alpha-3 chain

1

1

High-throughput

0.691

High

739933

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

1

Small-scale

0.691

High

740150

HSM3
DNA mismatch repair protein HSM3

4

1

Small-scale

0.683

High

645142

PSB4
Proteasome subunit beta type-4

4

20

Small-scale

0.683

High

740128

PRS6A
26S proteasome regulatory subunit 6A

4

20

High-throughput

0.683

High

740197

PRS10
26S proteasome subunit RPT4

4

20

High-throughput

0.683

High

636643

PSA1
Proteasome subunit alpha type-1

3

20

Small-scale

0.660

High

740171

PSA4
Proteasome subunit alpha type-4

3

20

Small-scale

0.660

High

740194

RPN14
26S proteasome regulatory subunit RPN14

3

5

High-throughput

0.660

High

740156

ECM29
Proteasome component ECM29

3

5

High-throughput

0.656

High

523387

HSP71
Heat shock protein SSA1

3

7

High-throughput

0.650

High

441072

KAPA
cAMP-dependent protein kinase type 1

1

3

High-throughput

0.647

High

448676

SNF1
Carbon catabolite-derepressing protein kinase

1

1

High-throughput

0.647

High

509457

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

17

High-throughput

0.647

High

602364

PHO85
Cyclin-dependent protein kinase PHO85

1

6

High-throughput

0.647

High

656395

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.647

High

740185

IKS1
Probable serine/threonine-protein kinase IKS1

1

1

High-throughput

0.647

High

740215

SKY1
Serine/threonine-protein kinase SKY1

1

9

High-throughput

0.647

High

437899

KAPC
cAMP-dependent protein kinase type 3

1

3

High-throughput

0.646

High

574654

KSS1
Mitogen-activated protein kinase KSS1

1

4

High-throughput

0.646

High

645895

DBF2
Cell cycle protein kinase DBF2

1

3

High-throughput

0.646

High

740176

PSMD9
Probable 26S proteasome regulatory subunit p27

3

3

Small-scale

0.640

High

646349

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.618

High

737804

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.618

High

740152

PSB1
Proteasome subunit beta type-1

2

20

High-throughput

0.611

High

670484

SIS1
Protein SIS1

2

3

High-throughput

0.601

High

636555

PSA7
Probable proteasome subunit alpha type-7

2

20

Small-scale

0.595

High

735907

PSA5
Proteasome subunit alpha type-5

2

20

Small-scale

0.595

High

740170

PSA6
Proteasome subunit alpha type-6

2

20

Small-scale

0.595

High

740201

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

7

Small-scale

0.595

High

579058

HSC82
ATP-dependent molecular chaperone HSC82

2

6

High-throughput

0.584

High

661483

PSA2
Proteasome subunit alpha type-2

2

20

High-throughput

0.584

High

740213

RPN4
Protein RPN4

2

0

Small-scale

0.582

High

734306

DBF20
Serine/threonine-protein kinase DBF20

1

4

High-throughput

0.578

High

440920

CDC7
Cell division control protein 7

1

11

Small-scale

0.575

High

526202

HSP72
Heat shock protein SSA2

2

7

High-throughput

0.571

High

740241

RUVB2
RuvB-like protein 2

2

3

High-throughput

0.571

High

531281

METK1
S-adenosylmethionine synthase 1

2

2

High-throughput

0.567

High

464578

PBS2
MAP kinase kinase PBS2

1

4

High-throughput

0.553

High

625948

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.537

High

544201

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.536

High

740135

SPT7
SAGA complex subunit SPT7

1

2

High-throughput

0.536

High

740138

EF1G2
Elongation factor 1-gamma 2

1

2

High-throughput

0.536

High

740191

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.536

High

740216

ESC1
Silent chromatin protein ESC1

2

3

High-throughput

0.533

High

740151

RCK2
Serine/threonine-protein kinase RCK2

1

0

High-throughput

0.517

High

740143

SN114
Pre-mRNA-splicing factor SNU114

1

3

High-throughput

0.515

High

646116

NPR1
Nitrogen permease reactivator protein

1

9

High-throughput

0.514

High

740192

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.513

High

740193

HUL5
E3 ubiquitin-protein ligase HUL5

1

9

Small-scale

0.501

High

651913

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.500

High

740153

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.500

High

740173

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.500

High

740196

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.500

High

740230

RBX1
RING-box protein HRT1

1

2

High-throughput

0.500

High

678938

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.493

High

740180

SPG5
Stationary phase protein 5

1

0

High-throughput

0.493

High

701674

URA7
CTP synthase 1

1

1

High-throughput

0.489

High

740133

MFT1
THO complex subunit MFT1

1

1

High-throughput

0.489

High

740141

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.489

High

740155

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.489

High

740179

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.489

High

740203

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.489

High

684061

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.479

High

740207

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

0

High-throughput

0.479

High

740228

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.479

High

740235

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.479

High

392432

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.479

High

434937

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

603025

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.479

High

647057

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

661387

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.479

High

662027

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.479

High

668373

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.479

High

675234

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.479

High

679497

CDC48
Cell division control protein 48

1

4

High-throughput

0.479

High

706534

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

709639

BMH1
Protein BMH1

1

3

High-throughput

0.479

High

721239

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.479

High

721293

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.479

High

726856

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

738792

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

740127

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

740140

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.479

High

740142

POC2
Proteasome assembly chaperone 2

1

1

High-throughput

0.479

High

740145

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

740148

UMP1
Proteasome maturation factor UMP1

1

1

High-throughput

0.479

High

740182

BLM10
Proteasome activator BLM10

1

4

High-throughput

0.479

High

740202

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

740206

CDC14
Tyrosine-protein phosphatase CDC14

1

8

Small-scale

0.479

High

740210

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.479

High

740211

ESP1
Separin

1

1

High-throughput

0.479

High

740212

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.479

High

740219

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

740224

POC1
Proteasome chaperone 1

1

1

High-throughput

0.479

High

740227

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.479

High

740231

SGO1
Shugoshin

1

1

High-throughput

0.479

High

740234

NSL1
Kinetochore-associated protein NSL1

1

1

Small-scale

0.479

High

740136

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

740220

CSN9
COP9 signalosome complex subunit 9

1

0

Small-scale

0.458

High

740221

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

740237

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

740166

RBG1
Ribosome-interacting GTPase 1

1

2

High-throughput

0.457

High

740240

LAS17
Proline-rich protein LAS17

1

2

High-throughput

0.457

High

675825

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

726034

FUN30
ATP-dependent helicase FUN30

1

3

High-throughput

0.445

High

740124

HSP7F
Heat shock protein homolog SSE1

1

9

High-throughput

0.445

High

740160

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.445

High

740169

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

1

High-throughput

0.445

High

740195

RAGCD
GTP-binding protein GTR2

1

1

High-throughput

0.445

High

740198

NOG2
Nucleolar GTP-binding protein 2

1

3

High-throughput

0.445

High

740199

HCH1
Hsp90 co-chaperone HCH1

1

4

High-throughput

0.445

High

740200

NOP13
Nucleolar protein 13

1

2

High-throughput

0.445

High

149657

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

383589

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

410008

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

430810

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.437

High

433524

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

435854

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

441788

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

454945

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

502924

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504110

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

512331

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

512894

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

514528

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

557576

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

Small-scale

0.437

High

616401

SEC18
Vesicular-fusion protein SEC18

1

6

High-throughput

0.437

High

674494

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

679038

FUB1
Silencing boundary-establishment protein FUB1

1

1

High-throughput

0.437

High

682213

SPB4
ATP-dependent rRNA helicase SPB4

1

4

High-throughput

0.437

High

689341

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

740126

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

740134

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

740137

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

740144

LONM
Lon protease homolog, mitochondrial

1

18

High-throughput

0.437

High

740146

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.437

High

740147

PHO88
SRP-independent targeting protein 3

1

1

High-throughput

0.437

High

740154

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

740175

MLP2
Protein MLP2

1

2

High-throughput

0.437

High

740181

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

740186

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.437

High

740188

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

740189

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

740205

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

740208

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

740214

HAS1
ATP-dependent RNA helicase HAS1

1

4

High-throughput

0.437

High

740217

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

740223

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

740229

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

740233

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

740239

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

740244

ENV10
SRP-independent targeting protein 2

1

1

High-throughput

0.437

High

597720

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

740149

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.426

High

740204

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

High-throughput

0.426

High

368332

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

5

High-throughput

0.407

High

456366

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

3

High-throughput

0.407

High

671602

SCJ1
DnaJ-related protein SCJ1

1

4

High-throughput

0.407

High

737438

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

2

High-throughput

0.407

High

740131

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

2

High-throughput

0.407

High

740132

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.407

High

740161

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.407

High

740162

TCPZ
T-complex protein 1 subunit zeta

1

3

High-throughput

0.407

High

740163

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

1

High-throughput

0.407

High

740167

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.407

High

740177

DJP1
DnaJ-like protein 1

1

4

High-throughput

0.407

High

740178

LCB2
Serine palmitoyltransferase 2

1

1

High-throughput

0.407

High

740187

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.407

High

740225

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

11

High-throughput

0.407

High

740243

GLT1
Glutamate synthase [NADH]

1

2

High-throughput

0.407

High

150156

THP2
THO complex subunit THP2

1

0

High-throughput

0.279

Low

740242

YO098
Uncharacterized protein YOL098C

1

0

High-throughput

0.279

Low

550634

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.269

Low

740139

DHR2
Probable ATP-dependent RNA helicase DHR2

1

0

High-throughput

0.261

Low

740158

GPI16
GPI transamidase component GPI16

1

0

High-throughput

0.261

Low

740165

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

740174

VPS27
Vacuolar protein sorting-associated protein 27

1

0

Small-scale

0.249

Low

740218

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

740164

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025