HitPredict

Interactor 1: COPA (Q27954)
Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]
Gene: COPA

Interactor 2: COPE (Q28104)
Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP)
Gene: COPE

Species: Bos taurus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.815

Property	Details
Experiments	20579721, 8858162
Identification Methods	molecular sieving, x-ray crystallography, two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	COPI_C~Coatomer_E
Common GO terms	GO:0000139 - Golgi membrane GO:0005198 - structural molecule activity GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006891 - intra-Golgi vesicle-mediated transport and 1 others more... GO:0030126 - COPI vesicle coat
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1224 Bt			1 308
+	Hs
		149588 COPA_HUMAN (1-1224): 0: 1289: 98.94		COPE_HUMAN (1-308): 8.63e-166: 464: 94.16
+	Dm
		1376088 Q9W0B8_DROME (1-1224): 0: 1145: 68.98		Q9Y0Y5_DROME (19-305): 1.75e-112: 329: 40.42
+	Sc
		774850 COPA_YEAST (1-1218): 0: 940: 42.72		COPE_YEAST (20-307): 1.67e-70: 221: 18.65
+	Hs
		149564 COPB2_HUMAN (197-962): 4.22e-45: 179: 12.81		COPE_HUMAN (1-308): 8.63e-166: 464: 94.16
+	Hs
		149595 WDR5_HUMAN (522-652): 3.86e-12: 70.9: 12.34		COPE_HUMAN (1-308): 8.63e-166: 464: 94.16
+	Ce
		248058 Q9N4H7_CAEEL (195-603): 5.13e-50: 196: 11.92		COPE_CAEEL (17-301): 3.45e-101: 300: 37.06
+	Sp
		251859 COPA_SCHPO (240-854): 5.27e-45: 179: 11.46		COPE_SCHPO (17-308): 5.85e-79: 243: 24.32
+	Sc
		774838 COPB2_YEAST (2-265): 3.66e-17: 89.3: 13.26		COPE_YEAST (20-307): 1.67e-70: 221: 18.65