HitPredict

Interactor 1: I1E4Y6 (I1E4Y6)
GRB10 interacting GYF protein 2
Gene: GIGYF2

Interactor 2: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043204 - perikaryon
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1321 Hs			1 2527
+	Hs
		725175 MYH10_HUMAN (595-1320): 2.22e-31: 136: 8.05		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130714 MYH2_HUMAN (246-1130): 2.19e-27: 123: 10.18		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		724862 MYH9_HUMAN (141-1086): 2.41e-27: 123: 10.14		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130259 KI21A_HUMAN (629-1283): 8.73e-26: 118: 14.89		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130576 SLK_HUMAN (738-1044): 1.34e-13: 78.1: 15.94		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1068556 PLEC_HUMAN (628-1252): 6.3e-10: 66.2: 16.98		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Hs
		1130255 MYH14_HUMAN (741-1044): 6.51e-10: 66.2: 19.15		LRRK2_HUMAN (1-2527): 0: 3008: 99.72
+	Mm
		1130137 PLEC_MOUSE (745-1252): 6.93e-09: 63.1: 17.22		LRRK2_MOUSE (1-2527): 0: 2865: 86.09
+	Hs
		1105465 RB6I2_HUMAN (637-1317): 2.74e-29: 129: 7.55		LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38
+	Hs
		972462 RB6I2_HUMAN (637-1317): 2.74e-29: 129: 7.55		M3K10_HUMAN (1864-2136): 2.39e-23: 110: 32.20
+	Hs
		201362 RB6I2_HUMAN (637-1317): 2.74e-29: 129: 7.55		M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83