HitPredict

Interactor 1: I6L996 (I6L996)
PTK2 protein
Gene: PTK2

Interactor 2: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	26871637
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 680 Hs			1 509
+	Hs
		411688 FAK1_HUMAN (5-680): 0: 651: 97.93		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		442812 FAK1_HUMAN (5-680): 0: 651: 97.93		HCK_HUMAN (1-509): 0: 602: 65.04
+	Hs
		111147 I6L996_HUMAN (1-680): 0: 658: 100.00		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		412143 FAK1_HUMAN (5-680): 0: 651: 97.93		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		522927 FAK1_HUMAN (5-680): 0: 651: 97.93		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		433716 FAK1_HUMAN (5-680): 0: 651: 97.93		LYN_HUMAN (1-509): 0: 582: 62.72
+	Hs
		433329 FAK1_HUMAN (5-680): 0: 651: 97.93		YES_HUMAN (26-507): 0: 581: 58.06
+	Hs
		454825 FAK1_HUMAN (5-680): 0: 651: 97.93		FGR_HUMAN (1-507): 0: 579: 52.76
+	Mm
		710126 FAK1_MOUSE (5-680): 0: 643: 94.68		FYN_MOUSE (30-507): 0: 586: 58.80
+	Gg
		337665 FAK1_CHICK (5-680): 0: 639: 91.89		SRC_CHICK (25-507): 0: 589: 56.79
+	Mm
		403419 FAK1_MOUSE (5-680): 0: 643: 94.68		SRC_MOUSE (28-507): 0: 583: 57.05
+	Hs
		411720 FAK2_HUMAN (10-671): 3.37e-168: 510: 46.02		LCK_HUMAN (1-509): 0: 661: 100.00
+	Rn
		936859 FAK2_RAT (9-671): 1.2e-172: 521: 46.25		SRC_RAT (27-507): 0: 584: 56.73
+	Mm
		403463 FAK2_MOUSE (10-671): 1.29e-171: 518: 46.47		SRC_MOUSE (28-507): 0: 583: 57.05
+	Hs
		412191 FAK2_HUMAN (10-671): 3.37e-168: 510: 46.02		FYN_HUMAN (30-507): 0: 586: 59.01
+	Hs
		522984 FAK2_HUMAN (10-671): 3.37e-168: 510: 46.02		SRC_HUMAN (20-507): 0: 586: 55.00
+	Hs
		433760 FAK2_HUMAN (10-671): 3.37e-168: 510: 46.02		LYN_HUMAN (1-509): 0: 582: 62.72
+	Mm
		763399 Q8C2G0_MOUSE (10-671): 5.95e-160: 487: 44.41		FYN_MOUSE (30-507): 0: 586: 58.80
+	Hs
		411606 MARK3_HUMAN (11-653): 1.34e-128: 399: 16.93		LCK_HUMAN (1-509): 0: 661: 100.00
+	Hs
		433589 MARK3_HUMAN (11-653): 1.34e-128: 399: 16.93		LYN_HUMAN (1-509): 0: 582: 62.72