HitPredict

Interactor 1: CBLB (Q3TTA7)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: SRBS1 (Q62417)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: Sorbs1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12842890
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Mm			1 1290
+	Hs
		298976 CBLB_HUMAN (1-982): 0: 926: 94.30		SRBS2_HUMAN (133-1288): 2.01e-124: 414: 25.94
+	Hs
		235501 CBLB_HUMAN (1-982): 0: 926: 94.30		VINEX_HUMAN (812-1288): 3.2e-43: 170: 31.19
+	Mm
		1112081 CBLB_MOUSE (1-982): 0: 947: 100.00		ITSN2_MOUSE (612-1288): 8.44e-31: 134: 10.01
+	Hs
		548699 CBLB_HUMAN (1-982): 0: 926: 94.30		VAV_HUMAN (557-1289): 1.58e-33: 142: 11.16
+	Hs
		1027627 CBLB_HUMAN (1-982): 0: 926: 94.30		ITSN2_HUMAN (474-1288): 1.49e-32: 140: 10.57
+	Hs
		1027629 CBLB_HUMAN (1-982): 0: 926: 94.30		VAV3_HUMAN (1044-1289): 1.01e-29: 130: 16.85
+	Mm
		1112072 CBLB_MOUSE (1-982): 0: 947: 100.00		GRAP_MOUSE (927-1106): 5.16e-26: 109: 19.34
+	Hs
		855791 CBLB_HUMAN (1-982): 0: 926: 94.30		VAV2_HUMAN (1033-1287): 9.51e-29: 127: 14.01
+	Mm
		82736 B9EKI5_MOUSE (1-982): 0: 916: 90.53		VAV2_MOUSE (1033-1287): 4.68e-29: 127: 14.66
+	Mm
		223012 CBLB_MOUSE (1-982): 0: 947: 100.00		NCK2_MOUSE (1000-1212): 1.68e-18: 91.1: 19.57
+	Mm
		1112053 CBLB_MOUSE (1-982): 0: 947: 100.00		GRB2_MOUSE (1233-1286): 2.84e-15: 78.4: 32.73
+	Hs
		209046 CBLB_HUMAN (1-982): 0: 926: 94.30		NCK2_HUMAN (973-1208): 5.89e-20: 95.7: 20.97
+	Mm
		82738 B9EKI5_MOUSE (1-982): 0: 916: 90.53		NCK1_MOUSE (985-1211): 3.33e-20: 96.1: 18.41
+	Hs
		924539 CBLB_HUMAN (1-982): 0: 926: 94.30		GRB2_HUMAN (1233-1286): 2.84e-15: 78.4: 32.73
+	Hs
		1027621 CBLB_HUMAN (1-982): 0: 926: 94.30		SH3K1_HUMAN (1022-1109): 7.84e-12: 71.8: 27.10
+	Mm
		82735 B9EKI5_MOUSE (1-982): 0: 916: 90.53		GRB2_MOUSE (1233-1286): 2.84e-15: 78.4: 32.73
+	Hs
		1027606 CBLB_HUMAN (1-982): 0: 926: 94.30		ITSN1_HUMAN (822-1288): 3.63e-10: 67: 11.75
+	Hs
		1027634 CBLB_HUMAN (1-982): 0: 926: 94.30		CD2AP_HUMAN (1129-1288): 2.89e-10: 66.6: 30.95
+	Hs
		1027613 CBLB_HUMAN (1-982): 0: 926: 94.30		SH3R1_HUMAN (833-1123): 3e-09: 63.5: 11.45
+	Hs
		557678 CBLB_HUMAN (1-982): 0: 926: 94.30		NCK1_HUMAN (1129-1285): 3.56e-09: 62.4: 31.48